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    FCGR3B Fc gamma receptor IIIb [ Homo sapiens (human) ]

    Gene ID: 2215, updated on 9-Dec-2024

    Summary

    Official Symbol
    FCGR3Bprovided by HGNC
    Official Full Name
    Fc gamma receptor IIIbprovided by HGNC
    Primary source
    HGNC:HGNC:3620
    See related
    Ensembl:ENSG00000162747 MIM:610665; AllianceGenome:HGNC:3620
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD16; FCG3; CD16A; CD16b; FCGR3; CD16-I; FCGR3A; FCR-10; FCRIII; FCRIIIb
    Summary
    The protein encoded by this gene is a low affinity receptor for the Fc region of gamma immunoglobulins (IgG). The encoded protein acts as a monomer and can bind either monomeric or aggregated IgG. This gene may function to capture immune complexes in the peripheral circulation. Several transcript variants encoding different isoforms have been found for this gene. A highly-similar gene encoding a related protein is also found on chromosome 1. [provided by RefSeq, Aug 2012]
    Expression
    Biased expression in spleen (RPKM 53.3), appendix (RPKM 50.9) and 7 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See FCGR3B in Genome Data Viewer
    Location:
    1q23.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (161623196..161631963, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (160967541..160976307, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (161592986..161601753, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:161581576-161582270 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:161582271-161582964 Neighboring gene tRNA-Leu (anticodon CAA) 6-1 Neighboring gene ribosomal protein S23 pseudogene 9 Neighboring gene Sharpr-MPRA regulatory region 4269 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:161608151-161608340 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1483 Neighboring gene Fc gamma receptor IIb Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:161640790-161641368 Neighboring gene ribosomal protein L31 pseudogene 11

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env IgG2 and IgG4 bind more poorly to enzymatically deglycosylated recombinant gp120 (rgp120) than to unchanged rgp120 PubMed
    Tat tat HIV-1 Tat upregulates the expression of CCR2, CD16, and TLR4 in monocyte-derived macrophages PubMed
    tat HIV-1 Tat inhibits the rise in intracellular free calcium concentration in Natural Killer (NK) cells upon cross-linking of the adhesion molecule CD11a and the activation molecule CD16, indicating Tat is involved in the impairment of NK cell function PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GPI anchor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables IgG binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables IgG receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in Fc-gamma receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in antibody-dependent cellular cytotoxicity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in secretory granule membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    low affinity immunoglobulin gamma Fc region receptor III-B
    Names
    Fc fragment of IgG receptor IIIb
    Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
    Fc gamma receptor III-B
    Fc-gamma receptor IIIb (CD 16)
    FcgammaRIIIb
    fc-gamma RIII-beta
    fc-gamma RIIIb
    igG Fc receptor III-1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032926.2 RefSeqGene

      Range
      5788..13768
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1238

    mRNA and Protein(s)

    1. NM_000570.5NP_000561.3  low affinity immunoglobulin gamma Fc region receptor III-B isoform 2 precursor

      See identical proteins and their annotated locations for NP_000561.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (2).
      Source sequence(s)
      AL451067
      Consensus CDS
      CCDS41433.1
      UniProtKB/Swiss-Prot
      O75015
      UniProtKB/TrEMBL
      A0A3B3ISU3, Q9UPY7
      Related
      ENSP00000356941.2, ENST00000367964.6
      Conserved Domains (2) summary
      cd05752
      Location:26104
      Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      cd05753
      Location:108190
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    2. NM_001244753.2NP_001231682.2  low affinity immunoglobulin gamma Fc region receptor III-B isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (2). Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AJ581669, AL451067, M24854, X16863
      Consensus CDS
      CCDS41433.1
      UniProtKB/Swiss-Prot
      O75015
      UniProtKB/TrEMBL
      A0A3B3ISU3, Q9UPY7
      Related
      ENSP00000497461.1, ENST00000650385.1
      Conserved Domains (2) summary
      cd05752
      Location:26104
      Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      cd05753
      Location:108190
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    3. NM_001271035.2NP_001257964.2  low affinity immunoglobulin gamma Fc region receptor III-B isoform 6 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site at the 5' end of an exon compared to variant 1. The resulting isoform (6) has the same N- and C-termini but is one aa shorter compared to isoform 2.
      Source sequence(s)
      AJ581669, AK316565, AL451067, DA673839
      Consensus CDS
      CCDS91090.1
      UniProtKB/TrEMBL
      H0Y4U3, Q9UPY7
      Related
      ENSP00000394204.3, ENST00000421702.4
      Conserved Domains (2) summary
      cd05752
      Location:25103
      Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      cd05753
      Location:107189
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    4. NM_001271036.2NP_001257965.1  low affinity immunoglobulin gamma Fc region receptor III-B isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (4) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AL451067
      UniProtKB/TrEMBL
      Q9UPY7
      Conserved Domains (2) summary
      cd05752
      Location:987
      Ig1_FcgammaR_like; First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains
      cd05753
      Location:91173
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains
    5. NM_001271037.2NP_001257966.1  low affinity immunoglobulin gamma Fc region receptor III-B isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (5) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 1.
      Source sequence(s)
      AL451067
      UniProtKB/Swiss-Prot
      O75015
      UniProtKB/TrEMBL
      A0A087WU90
      Conserved Domains (1) summary
      cd05752
      Location:987
      Ig1_FcgammaR_like; First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      161623196..161631963 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      160967541..160976307 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)