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    TRIM33 tripartite motif containing 33 [ Homo sapiens (human) ]

    Gene ID: 51592, updated on 10-Dec-2024

    Summary

    Official Symbol
    TRIM33provided by HGNC
    Official Full Name
    tripartite motif containing 33provided by HGNC
    Primary source
    HGNC:HGNC:16290
    See related
    Ensembl:ENSG00000197323 MIM:605769; AllianceGenome:HGNC:16290
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ECTO; PTC7; RFG7; TF1G; TIF1G; TIFGAMMA; TIF1GAMMA
    Summary
    The protein encoded by this gene is thought to be a transcriptional corepressor. However, molecules that interact with this protein have not yet been identified. The protein is a member of the tripartite motif family. This motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Three alternatively spliced transcript variants for this gene have been described, however, the full-length nature of one variant has not been determined. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 10.8), endometrium (RPKM 8.6) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See TRIM33 in Genome Data Viewer
    Location:
    1p13.2
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (114392790..114511203, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (114404478..114522654, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (114935412..115053824, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L57 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:114888268-114888768 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:114891333-114891833 Neighboring gene H3K4me1 hESC enhancers GRCh37_chr1:114895122-114895622 and GRCh37_chr1:114895623-114896123 Neighboring gene trafficking kinesin protein 2 pseudogene Neighboring gene MPRA-validated peak378 silencer Neighboring gene Sharpr-MPRA regulatory region 2420 Neighboring gene Sharpr-MPRA regulatory region 2597 Neighboring gene ribosomal protein L26 pseudogene 10 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:115020350-115020850 Neighboring gene eukaryotic translation initiation factor 2 subunit 2 beta pseudogene 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1545 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1219 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1220 Neighboring gene uncharacterized LOC124904348 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1546 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:115055021-115055783 Neighboring gene pyruvate kinase M1/2 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (57 hits/1340 screens)

    EBI GWAS Catalog

    Description
    Common genetic variants on 1p13.2 associate with risk of autism.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • FLJ32925

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding  
    enables R-SMAD binding PubMed 
    enables co-SMAD binding PubMed 
    enables protein binding PubMed 
    enables ubiquitin-protein transferase activity  
    enables zinc ion binding  
    Component Evidence Code Pubs
    located_in chromatin  
    located_in nucleoplasm  
    located_in nucleus PubMed 

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase TRIM33
    Names
    RET-fused gene 7 protein
    RING-type E3 ubiquitin transferase TRIM33
    TIF1-gamma
    ectodermin homolog
    protein Rfg7
    transcriptional intermediary factor 1 gamma
    NP_056990.3
    NP_148980.2
    XP_005270993.1
    XP_005270994.1
    XP_011539870.1
    XP_016856943.1
    XP_047278468.1
    XP_054192952.1
    XP_054192953.1
    XP_054192954.1
    XP_054192955.1
    XP_054192956.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_023287.2 RefSeqGene

      Range
      5000..123413
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_015906.4 → NP_056990.3  E3 ubiquitin-protein ligase TRIM33 isoform alpha

      See identical proteins and their annotated locations for NP_056990.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (a) encodes the longer isoform (alpha).
      Source sequence(s)
      AB029036, AF119043, AK023434, AL035410, AL390241, CN267696
      Consensus CDS
      CCDS872.1
      UniProtKB/Swiss-Prot
      O95855, Q5TG72, Q5TG73, Q5TG74, Q9C017, Q9UJ79, Q9UPN9
      Related
      ENSP00000351250.2, ENST00000358465.7
      Conserved Domains (6) summary
      cd05502
      Location:958 → 1083
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:319 → 445
      BBC; B-Box C-terminal domain
      smart00336
      Location:212 → 248
      BBOX; B-Box-type zinc finger
      cd00021
      Location:274 → 312
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cd00162
      Location:124 → 188
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd15624
      Location:889 → 934
      PHD_TIF1gamma; PHD finger found in transcriptional intermediary factor 1 gamma (TIF1gamma)
    2. NM_033020.3 → NP_148980.2  E3 ubiquitin-protein ligase TRIM33 isoform beta

      See identical proteins and their annotated locations for NP_148980.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (b) lacks exon 15 of the coding region. The reading frame is maintained and the encoded protein, isoform beta, lacks an internal 17 aa fragment as compared to isoform alpha.
      Source sequence(s)
      AB029036, AF119043, AF220137, AK023434, AL035410, AL390241, CN267696
      Consensus CDS
      CCDS873.1
      Related
      ENSP00000358556.2, ENST00000369543.6
      Conserved Domains (6) summary
      cd05502
      Location:958 → 1066
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:319 → 445
      BBC; B-Box C-terminal domain
      smart00336
      Location:212 → 248
      BBOX; B-Box-type zinc finger
      cd00021
      Location:274 → 312
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cd00162
      Location:124 → 188
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd15624
      Location:889 → 934
      PHD_TIF1gamma; PHD finger found in transcriptional intermediary factor 1 gamma (TIF1gamma)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      114392790..114511203 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047422512.1 → XP_047278468.1  E3 ubiquitin-protein ligase TRIM33 isoform X4

    2. XM_011541568.4 → XP_011539870.1  E3 ubiquitin-protein ligase TRIM33 isoform X2

      Conserved Domains (6) summary
      cd05502
      Location:981 → 1106
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:319 → 445
      BBC; B-Box C-terminal domain
      smart00336
      Location:212 → 248
      BBOX; B-Box-type zinc finger
      cd00021
      Location:274 → 312
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cd00162
      Location:124 → 188
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd15624
      Location:912 → 957
      PHD_TIF1gamma; PHD finger found in transcriptional intermediary factor 1 gamma (TIF1gamma)
    3. XM_005270937.5 → XP_005270994.1  E3 ubiquitin-protein ligase TRIM33 isoform X3

      Conserved Domains (6) summary
      cd05502
      Location:982 → 1090
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:319 → 445
      BBC; B-Box C-terminal domain
      smart00336
      Location:212 → 248
      BBOX; B-Box-type zinc finger
      cd00021
      Location:274 → 312
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cd00162
      Location:124 → 188
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd15624
      Location:913 → 958
      PHD_TIF1gamma; PHD finger found in transcriptional intermediary factor 1 gamma (TIF1gamma)
    4. XM_005270936.5 → XP_005270993.1  E3 ubiquitin-protein ligase TRIM33 isoform X1

      Conserved Domains (6) summary
      cd05502
      Location:982 → 1107
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:319 → 445
      BBC; B-Box C-terminal domain
      smart00336
      Location:212 → 248
      BBOX; B-Box-type zinc finger
      cd00021
      Location:274 → 312
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cd00162
      Location:124 → 188
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd15624
      Location:913 → 958
      PHD_TIF1gamma; PHD finger found in transcriptional intermediary factor 1 gamma (TIF1gamma)
    5. XM_017001454.3 → XP_016856943.1  E3 ubiquitin-protein ligase TRIM33 isoform X5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      114404478..114522654 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054336980.1 → XP_054192955.1  E3 ubiquitin-protein ligase TRIM33 isoform X4

    2. XM_054336978.1 → XP_054192953.1  E3 ubiquitin-protein ligase TRIM33 isoform X2

    3. XM_054336979.1 → XP_054192954.1  E3 ubiquitin-protein ligase TRIM33 isoform X3

    4. XM_054336977.1 → XP_054192952.1  E3 ubiquitin-protein ligase TRIM33 isoform X1

    5. XM_054336981.1 → XP_054192956.1  E3 ubiquitin-protein ligase TRIM33 isoform X5

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