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    LARP4B La ribonucleoprotein 4B [ Homo sapiens (human) ]

    Gene ID: 23185, updated on 3-Dec-2024

    Summary

    Official Symbol
    LARP4Bprovided by HGNC
    Official Full Name
    La ribonucleoprotein 4Bprovided by HGNC
    Primary source
    HGNC:HGNC:28987
    See related
    Ensembl:ENSG00000107929 MIM:616513; AllianceGenome:HGNC:28987
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LARP5; KIAA0217
    Summary
    This gene encodes a member of an evolutionarily conserved protein family implicated in RNA metabolism and translation. Members of this family are characterized by the presence of an La motif, which is often located adjacent to one or more RNA recognition motifs (RRM). Together, the two motifs constitute the functional region of the protein and enable its interaction with the RNA substrate. This protein family is divided into five sub-families: the genuine La proteins and four La-related protein (LARP) sub-families. The protein encoded by this gene belongs to LARP sub-family 4. It is a cytoplasmic protein that may play a stimulatory role in translation. [provided by RefSeq, Oct 2012]
    Expression
    Ubiquitous expression in thyroid (RPKM 6.7), testis (RPKM 6.0) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See LARP4B in Genome Data Viewer
    Location:
    10p15.3
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (806914..988341, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (804686..932709, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (852854..977645, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene disco interacting protein 2 homolog C Neighboring gene uncharacterized LOC124902361 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:696476-697298 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:709923-710450 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:717375-717875 Neighboring gene DIP2C antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:735983-736918 Neighboring gene microRNA 5699 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:745902-746402 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:746403-746903 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:771745-772245 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:791683-792184 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:792185-792684 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:805871-806370 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:833618-834539 Neighboring gene HNF4 motif-containing MPRA enhancer 225 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:855234-855734 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:855735-856235 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:860152-860652 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:860653-861153 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:879525-879763 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_17861 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:908856-909700 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2059 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2060 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2061 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2062 Neighboring gene keratinocyte proline-rich protein-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2063 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:989167-989668 Neighboring gene LARP4B divergent transcript Neighboring gene Sharpr-MPRA regulatory region 2332 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:1036121-1037016 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:1050745-1051244 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:1054558-1055058 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:1055059-1055559 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2894 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2893 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:1088961-1090160 Neighboring gene GTP binding protein 4 Neighboring gene IDI2 antisense RNA 1 Neighboring gene isopentenyl-diphosphate delta isomerase 2 Neighboring gene isopentenyl-diphosphate delta isomerase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp686M23113

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of 3'-UTR-mediated mRNA stabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasmic stress granule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane HDA PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    la-related protein 4B
    Names
    La ribonucleoprotein domain family member 4B
    La ribonucleoprotein domain family, member 5
    la-related protein 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001351277.2NP_001338206.1  la-related protein 4B isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) is longer than isoform 1.
      Source sequence(s)
      AL157709, AU132926, BC152443, BM684990, HY013410
      UniProtKB/TrEMBL
      A0A8I5KWN8
      Conserved Domains (2) summary
      cd08036
      Location:157231
      LARP_5; La RNA-binding domain of La-related protein 5
      cd12706
      Location:236312
      RRM_LARP5; RNA recognition motif in vertebrate La-related protein 5 (LARP5 or LARP4B)
    2. NM_015155.3NP_055970.1  la-related protein 4B isoform 1

      See identical proteins and their annotated locations for NP_055970.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the shorter isoform (1).
      Source sequence(s)
      AL157709, AL359878
      Consensus CDS
      CCDS31131.1
      UniProtKB/Swiss-Prot
      A7MD20, Q5T3R3, Q5T3R4, Q5T3R5, Q68CY4, Q92615
      UniProtKB/TrEMBL
      A0A8I5KWN8
      Related
      ENSP00000326128.3, ENST00000316157.8
      Conserved Domains (2) summary
      cd08036
      Location:157231
      LARP_5; La RNA-binding domain of La-related protein 5
      cd12706
      Location:236312
      RRM_LARP5; RNA recognition motif in vertebrate La-related protein 5 (LARP5 or LARP4B)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      806914..988341 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047424897.1XP_047280853.1  la-related protein 4B isoform X5

      UniProtKB/Swiss-Prot
      A7MD20, Q5T3R3, Q5T3R4, Q5T3R5, Q68CY4, Q92615
      UniProtKB/TrEMBL
      A0A8I5KWN8
      Related
      ENSP00000509705.1, ENST00000688365.1
    2. XM_047424894.1XP_047280850.1  la-related protein 4B isoform X4

      UniProtKB/TrEMBL
      A0A8I5KWN8
    3. XM_047424893.1XP_047280849.1  la-related protein 4B isoform X4

      UniProtKB/TrEMBL
      A0A8I5KWN8
    4. XM_047424896.1XP_047280852.1  la-related protein 4B isoform X5

      UniProtKB/Swiss-Prot
      A7MD20, Q5T3R3, Q5T3R4, Q5T3R5, Q68CY4, Q92615
      UniProtKB/TrEMBL
      A0A8I5KWN8
    5. XM_047424892.1XP_047280848.1  la-related protein 4B isoform X4

      UniProtKB/TrEMBL
      A0A8I5KWN8
    6. XM_047424895.1XP_047280851.1  la-related protein 4B isoform X4

      UniProtKB/TrEMBL
      A0A8I5KWN8
    7. XM_017015990.2XP_016871479.1  la-related protein 4B isoform X4

      UniProtKB/TrEMBL
      A0A8I5KWN8
      Conserved Domains (2) summary
      cd08036
      Location:157231
      LARP_5; La RNA-binding domain of La-related protein 5
      cd12706
      Location:236312
      RRM_LARP5; RNA recognition motif in vertebrate La-related protein 5 (LARP5 or LARP4B)
    8. XM_017015988.2XP_016871477.1  la-related protein 4B isoform X2

    9. XM_017015987.2XP_016871476.1  la-related protein 4B isoform X1

    10. XM_017015992.2XP_016871481.1  la-related protein 4B isoform X9

      UniProtKB/TrEMBL
      A0A8I5KWN8
      Conserved Domains (2) summary
      cd12706
      Location:79155
      RRM_LARP5; RNA recognition motif in vertebrate La-related protein 5 (LARP5 or LARP4B)
      cl02755
      Location:2674
      LAM; LA motif RNA-binding domain
    11. XM_047424902.1XP_047280858.1  la-related protein 4B isoform X10

      UniProtKB/TrEMBL
      A0A8I5KWN8
    12. XM_047424901.1XP_047280857.1  la-related protein 4B isoform X8

      UniProtKB/TrEMBL
      A0A8I5KWN8
    13. XM_047424898.1XP_047280854.1  la-related protein 4B isoform X6

      UniProtKB/TrEMBL
      A0A8I5KWN8
    14. XM_047424899.1XP_047280855.1  la-related protein 4B isoform X6

      UniProtKB/TrEMBL
      A0A8I5KWN8
    15. XM_017015989.2XP_016871478.1  la-related protein 4B isoform X3

    16. XM_047424900.1XP_047280856.1  la-related protein 4B isoform X7

    17. XM_017015995.2XP_016871484.1  la-related protein 4B isoform X11

    RNA

    1. XR_001747069.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      804686..932709 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054365328.1XP_054221303.1  la-related protein 4B isoform X5

      UniProtKB/TrEMBL
      A0A8I5KWN8
    2. XM_054365325.1XP_054221300.1  la-related protein 4B isoform X4

      UniProtKB/TrEMBL
      A0A8I5KWN8
    3. XM_054365327.1XP_054221302.1  la-related protein 4B isoform X5

      UniProtKB/TrEMBL
      A0A8I5KWN8
    4. XM_054365324.1XP_054221299.1  la-related protein 4B isoform X4

      UniProtKB/TrEMBL
      A0A8I5KWN8
    5. XM_054365326.1XP_054221301.1  la-related protein 4B isoform X4

      UniProtKB/TrEMBL
      A0A8I5KWN8
    6. XM_054365323.1XP_054221298.1  la-related protein 4B isoform X4

      UniProtKB/TrEMBL
      A0A8I5KWN8
    7. XM_054365320.1XP_054221295.1  la-related protein 4B isoform X1

    8. XM_054365321.1XP_054221296.1  la-related protein 4B isoform X2

    9. XM_054365333.1XP_054221308.1  la-related protein 4B isoform X9

      UniProtKB/TrEMBL
      A0A8I5KWN8
    10. XM_054365334.1XP_054221309.1  la-related protein 4B isoform X10

      UniProtKB/TrEMBL
      A0A8I5KWN8
    11. XM_054365332.1XP_054221307.1  la-related protein 4B isoform X8

      UniProtKB/TrEMBL
      A0A8I5KWN8
    12. XM_054365329.1XP_054221304.1  la-related protein 4B isoform X6

      UniProtKB/TrEMBL
      A0A8I5KWN8
    13. XM_054365330.1XP_054221305.1  la-related protein 4B isoform X6

      UniProtKB/TrEMBL
      A0A8I5KWN8
    14. XM_054365322.1XP_054221297.1  la-related protein 4B isoform X3

    15. XM_054365331.1XP_054221306.1  la-related protein 4B isoform X7

    16. XM_054365335.1XP_054221310.1  la-related protein 4B isoform X11

    RNA

    1. XR_008488184.1 RNA Sequence