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    soxS DNA-binding transcriptional dual regulator SoxS [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948567, updated on 3-Dec-2024

    Summary

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    Official Symbol
    soxS
    Official Full Name
    DNA-binding transcriptional dual regulator SoxS
    Primary source
    ECOCYC:EG10958
    Locus tag
    b4062
    See related
    ASAP:ABE-0013311
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4054
    Summary
    Induces sox regulon when superoxide levels increase. [More information is available at EcoGene: EG10958]. SoxS belongs to the AraC/XylS family. [More information is available at EcoCyc: EG10958].
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    Genomic context

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    Sequence:
    NC_000913.3 (4277060..4277383, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein YjcB Neighboring gene c-di-GMP phosphodiesterase PdeC Neighboring gene DNA-binding transcriptional dual regulator SoxR Neighboring gene ncRNA Neighboring gene guanine/hypoxanthine transporter GhxP

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Redox signal transduction via iron-sulfur clusters in the SoxR transcription activator. Hidalgo E, et al. Trends Biochem Sci, 1997 Jun. PMID 9204707
    2. Structural basis of three different transcription activation strategies adopted by a single regulator SoxS. Shi J, et al. Nucleic Acids Res, 2022 Oct 28. PMID 36243985, Free PMC Article
    3. Polyamines reduce paraquat-induced soxS and its regulon expression in Escherichia coli. Jung IL, et al. Cell Biol Toxicol, 2003 Feb. PMID 12661985
    4. Oxidative stress in bacteria and protein damage by reactive oxygen species. Cabiscol E, et al. Int Microbiol, 2000 Mar. PMID 10963327
    5. Reactive oxygen species mediate lethality induced by far-UV in Escherichia coli cells. Gomes AA, et al. Redox Rep, 2005. PMID 15949129

    See all (111) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural basis of three different transcription activation strategies adopted by a single regulator SoxS.
      Title: Structural basis of three different transcription activation strategies adopted by a single regulator SoxS.
    2. PCR analysis of RNA from the wild-type, DeltaacrR, and acrR (+) strains showed that AcrR represses the transcription of marRAB and soxRS, and its own gene cluster, acrRAB.
      Title: Overproduction of AcrR increases organic solvent tolerance mediated by modulation of SoxS regulon in Escherichia coli.
    3. Genetic defects in SoxS, MarA, or AcrB underlie superoxide-mediated protection of Escherichia coli from antimicrobials.
      Title: Superoxide-mediated protection of Escherichia coli from antimicrobials.
    4. In this study, microarrays and RT-PCR analysis were used to show the overexpression of the ompN porin and its upstream gene, ydbK, in an Escherichia coli multidrug-resistant mutant and in a strain constitutive for SoxS.
      Title: SoxS-dependent coregulation of ompN and ydbK in a multidrug-resistant Escherichia coli strain.
    5. There is a transient change in the activity of the iron regulator Fur and of the oxidative stress regulator SoxS after Zn addition.
      Title: Dynamics of a starvation-to-surfeit shift: a transcriptomic and modelling analysis of the bacterial response to zinc reveals transient behaviour of the Fur and SoxS regulators.
    6. This work implicates SoxS control of znuCB expression as a key factor in persistence of Escherichia coli in murine pyelonephritis.
      Title: SoxS increases the expression of the zinc uptake system ZnuACB in an Escherichia coli murine pyelonephritis model.
    7. The results indicate that activation of the soxRS regulon in E. coli cells exposed to superoxide-propagating compounds can be triggered by depletion of the NADPH stock rather than accumulation of superoxide itself.
      Title: The soxRS response of Escherichia coli can be induced in the absence of oxidative stress and oxygen by modulation of NADPH content.
    8. Genetic evidence for a novel interaction between transcriptional activator soxs and region 4 of the sigma(70) subunit of RNA polymerase at class ii SoxS-dependent promoters in Escherichia coli
      Title: Genetic evidence for a novel interaction between transcriptional activator SoxS and region 4 of the σ(70) subunit of RNA polymerase at class II SoxS-dependent promoters in Escherichia coli.
    9. SoxS is now the first example of an E. coli transcriptional activator that uses a single positive control surface to make specific protein-protein contacts with two different subunits of RNAP.
      Title: Protein-protein interactions between sigma(70) region 4 of RNA polymerase and Escherichia coli SoxS, a transcription activator that functions by the prerecruitment mechanism: evidence for "off-DNA" and "on-DNA" interactions.
    10. roles of the Escherichia coli transcriptional regulators MarA, SoxS and Rob in susceptibility to cationic antimicrobial peptides
      Title: Different effects of transcriptional regulators MarA, SoxS and Rob on susceptibility of Escherichia coli to cationic antimicrobial peptides (CAMPs): Rob-dependent CAMP induction of the marRAB operon.
    Submit: New GeneRIF Correction See all GeneRIFs (18)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables bacterial-type RNA polymerase holo enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables bacterial-type RNA polymerase holo enzyme binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DNA-binding transcriptional dual regulator SoxS

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4277060..4277383 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418486.1 DNA-binding transcriptional dual regulator SoxS [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418486.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9AQW4
      Conserved Domains (1) summary
      PRK10219
      Location:1 → 107
      PRK10219; superoxide response transcriptional regulator SoxS
    Nucleotide Protein
    Heading Accession and Version

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