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    ybaK Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase YbaK [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947083, updated on 3-Dec-2024

    Summary

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    Official Symbol
    ybaK
    Official Full Name
    Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase YbaK
    Primary source
    ECOCYC:EG12454
    Locus tag
    b0481
    See related
    ASAP:ABE-0001670
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0475
    Summary
    YbaK has weak in vitro deacylase activity against Gly-, Ala-, Ser- Pro- and Met-tRNAs. [More information is available at EcoGene: EG12454]. YbaK has similarity to the editing active site (INS domain) of ProRS. [More information is available at EcoCyc: EG12454].
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    Genomic context

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    Sequence:
    NC_000913.3 (506603..507082, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene fosmidomycin efflux pump Neighboring gene 5'-nucleotidase/UDP-sugar hydrolase Neighboring gene ncRNA Neighboring gene TraB family protein YbaP Neighboring gene DNA-binding transcriptional regulator YbaQ

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. JEvTrace: refinement and variations of the evolutionary trace in JAVA. Joachimiak MP, et al. Genome Biol, 2002. PMID 12537566, Free PMC Article
    2. Stoichiometry of triple-sieve tRNA editing complex ensures fidelity of aminoacyl-tRNA formation. Chen L, et al. Nucleic Acids Res, 2019 Jan 25. PMID 30418624, Free PMC Article
    3. Nucleotide sequence and transcriptional analysis of the E. coli ushA gene, encoding periplasmic UDP-sugar hydrolase (5'-nucleotidase): regulation of the ushA gene, and the signal sequence of its encoded protein product. Burns DM, et al. Nucleic Acids Res, 1986 May 27. PMID 3012467, Free PMC Article
    4. Enrichment of low abundance proteins of Escherichia coli by hydroxyapatite chromatography. Fountoulakis M, et al. Electrophoresis, 1999 Aug. PMID 10493123
    5. Screen for genes involved in radiation survival of Escherichia coli and construction of a reference database. Sargentini NJ, et al. Mutat Res, 2016 Nov-Dec. PMID 27718375

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. data suggest that YbaK-mediated hydrolysis of aminoacyl-tRNA can influence cell growth
      Title: The bacterial YbaK protein is a Cys-tRNAPro and Cys-tRNA Cys deacylase.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    NOT enables Ala-tRNA(Pro) hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables Cys-tRNA(Pro) hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aminoacyl-tRNA editing activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aminoacyl-tRNA editing activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA editing activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in aminoacyl-tRNA metabolism involved in translational fidelity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to X-ray IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase YbaK

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      506603..507082 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415014.1 Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase YbaK [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415014.1

      Status: PROVISIONAL

      Conserved Domains (1) summary
      PRK10670
      Location:1 → 159
      PRK10670; Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase YbaK
    Nucleotide Protein
    Heading Accession and Version

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