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    TREM1 triggering receptor expressed on myeloid cells 1 [ Homo sapiens (human) ]

    Gene ID: 54210, updated on 3-Dec-2024

    Summary

    Official Symbol
    TREM1provided by HGNC
    Official Full Name
    triggering receptor expressed on myeloid cells 1provided by HGNC
    Primary source
    HGNC:HGNC:17760
    See related
    Ensembl:ENSG00000124731 MIM:605085; AllianceGenome:HGNC:17760
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD354; TREM-1
    Summary
    This gene encodes a receptor belonging to the Ig superfamily that is expressed on myeloid cells. This protein amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]
    Expression
    Biased expression in bone marrow (RPKM 10.0), appendix (RPKM 9.0) and 7 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TREM1 in Genome Data Viewer
    Location:
    6p21.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (41267385..41286682, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (41096688..41115965, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (41235123..41254420, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:41206864-41207400 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:41207401-41207935 Neighboring gene RNA, 5S ribosomal pseudogene 207 Neighboring gene triggering receptor expressed on myeloid cells like 5, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17175 Neighboring gene NANOG hESC enhancer GRCh37_chr6:41272623-41273180 Neighboring gene RNA, U6 small nuclear 643, pseudogene Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr6:41273648-41274847 Neighboring gene ribosomal protein L32 pseudogene 15

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 upregulates the expression of triggering receptor expressed on myeloid cells 1 (TREM1) in peptide-treated PBMCs PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables receptor decoy activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables scaffold protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transmembrane signaling receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cytokine production involved in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in humoral immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in neutrophil chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neutrophil-mediated killing of gram-negative bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    triggering receptor expressed on myeloid cells 1
    Names
    triggering receptor expressed on monocytes 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029525.2 RefSeqGene

      Range
      5038..18115
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001242589.3NP_001229518.1  triggering receptor expressed on myeloid cells 1 isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs at the 3' end compared to variant 1. This results in a shorter isoform (2) with a distinct C-terminus, lacking the transmembrane domain, compared to isoform 1.
      Source sequence(s)
      AF287008, AK223264, AL391903, DC428714
      Consensus CDS
      CCDS59499.1
      UniProtKB/TrEMBL
      A8K7Z7
      Related
      ENSP00000465345.1, ENST00000591620.1
      Conserved Domains (1) summary
      cl11960
      Location:33118
      Ig; Immunoglobulin domain
    2. NM_001242590.3NP_001229519.1  triggering receptor expressed on myeloid cells 1 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001229519.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3; also known as TREM1-sv, PMID:11922939) is missing an internal coding exon compared to variant 1. This results in a frame-shift, and a shorter isoform (3) with a distinct C-terminus compared to isoform 1. This isoform, lacking the transmembrane domain, is likely secreted, and may function as a regulator of myeloid activation (PMID:11922939).
      Source sequence(s)
      AK301519, AL391903, CA417244, DA362458, DA938757
      Consensus CDS
      CCDS56427.1
      UniProtKB/Swiss-Prot
      Q9NP99
      Related
      ENSP00000334284.5, ENST00000334475.11
      Conserved Domains (2) summary
      smart00410
      Location:27133
      IG_like; Immunoglobulin like
      cl11960
      Location:32134
      Ig; Immunoglobulin domain
    3. NM_018643.5NP_061113.1  triggering receptor expressed on myeloid cells 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_061113.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AF287008, AL391903, CA417244, DA362458, DA938757
      Consensus CDS
      CCDS4854.1
      UniProtKB/Swiss-Prot
      B4DWG2, K7EJW1, Q53FL8, Q5T2C9, Q86YU1, Q9NP99
      UniProtKB/TrEMBL
      A8K7Z7, Q38L15
      Related
      ENSP00000244709.3, ENST00000244709.9
      Conserved Domains (1) summary
      cl11960
      Location:33118
      Ig; Immunoglobulin domain

    RNA

    1. NR_136332.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate 5' and 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AF287008, AL391903, AW264786, BI910026, DA362458, DA938757

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      41267385..41286682 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011514696.3XP_011512998.1  triggering receptor expressed on myeloid cells 1 isoform X1

      See identical proteins and their annotated locations for XP_011512998.1

      UniProtKB/TrEMBL
      A8K7Z7, K7EKM5
      Related
      ENSP00000465688.1, ENST00000589614.6
      Conserved Domains (1) summary
      cl11960
      Location:33118
      Ig; Immunoglobulin domain
    2. XM_011514697.1XP_011512999.1  triggering receptor expressed on myeloid cells 1 isoform X2

      Conserved Domains (2) summary
      smart00410
      Location:27133
      IG_like; Immunoglobulin like
      cl11960
      Location:32134
      Ig; Immunoglobulin domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      41096688..41115965 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054355669.1XP_054211644.1  triggering receptor expressed on myeloid cells 1 isoform X1

      UniProtKB/TrEMBL
      A8K7Z7, K7EKM5
    2. XM_054355670.1XP_054211645.1  triggering receptor expressed on myeloid cells 1 isoform X2