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    HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 [ Homo sapiens (human) ]

    Gene ID: 51191, updated on 27-Nov-2024

    Summary

    Official Symbol
    HERC5provided by HGNC
    Official Full Name
    HECT and RLD domain containing E3 ubiquitin protein ligase 5provided by HGNC
    Primary source
    HGNC:HGNC:24368
    See related
    Ensembl:ENSG00000138646 MIM:608242; AllianceGenome:HGNC:24368
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CEB1; CEBP1
    Summary
    This gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. The protein also acts as a modulator of the antiviral immune response. The gene lies in a cluster of HERC family genes on chromosome 4. [provided by RefSeq, Aug 2021]
    Annotation information
    Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
    Expression
    Broad expression in testis (RPKM 31.7), endometrium (RPKM 6.3) and 17 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See HERC5 in Genome Data Viewer
    Location:
    4q22.1
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (88457119..88506163)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (91788779..91837819)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (89378270..89427314)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377326 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15563 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21713 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21714 Neighboring gene HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 Neighboring gene uncharacterized LOC102723458 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21715 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:89403116-89403280 Neighboring gene nuclear receptor coactivator 4 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21716 Neighboring gene PIGY upstream open reading frame Neighboring gene phosphatidylinositol glycan anchor biosynthesis class Y

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study of lung function decline in adults with and without asthma.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Interaction of HIV-1 Gag with HECT and RLD domain containing E3 ubiquitin protein ligase 5 (HERC5) is identified in a series of six affinity purification/mass spectrometry screens PubMed
    gag HERC5-induced restriction of Gag particle production is distinct from ISG15-only restriction PubMed
    gag HERC5 restricts HIV-1 Gag particle production by a mechanism dependent on its E3 ligase activity. This restriction correlates with the conjugation of ISG15 to Gag by HERC5 PubMed
    gag HIV-1 Gag co-localizes with HERC5 in cells PubMed
    Rev rev HERC5 relocalizes HIV-1 Rev from nucleus to nuclear membrane and cytoplasm to inhibit Rev/RRE function PubMed
    Vpr vpr HIV-1 Vpr upregulates the gene expression of HERC5 in human monocyte-derived dendritic cells PubMed
    capsid gag Both HERC5 and HERC5-C994A mutant inhibit HIV-1 particle production with decreased levels of HIV-1 CA in cells and virions PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ISG15 transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ISG15 transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin-protein transferase activity TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    E3 ISG15--protein ligase HERC5
    Names
    HECT domain and RCC1-like domain-containing protein 5
    cyclin-E-binding protein 1
    hect domain and RLD 5
    probable E3 ubiquitin-protein ligase HERC5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016323.4NP_057407.2  E3 ISG15--protein ligase HERC5

      See identical proteins and their annotated locations for NP_057407.2

      Status: REVIEWED

      Source sequence(s)
      AC083829, AI336946, AK302142, AY337518, BC140716
      Consensus CDS
      CCDS3630.1
      UniProtKB/Swiss-Prot
      B2RTQ1, Q69G20, Q9UII4
      Related
      ENSP00000264350.3, ENST00000264350.8
      Conserved Domains (4) summary
      smart00119
      Location:7051023
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:6811024
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00415
      Location:261309
      RCC1; Regulator of chromosome condensation (RCC1) repeat
      pfam13540
      Location:140169
      RCC1_2; Regulator of chromosome condensation (RCC1) repeat

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      88457119..88506163
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011532022.3XP_011530324.3  E3 ISG15--protein ligase HERC5 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      91788779..91837819
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054350157.1XP_054206132.1  E3 ISG15--protein ligase HERC5 isoform X1