folB dihydroneopterin aldolase [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

Official Symbol: folB
Official Full Name: dihydroneopterin aldolase
Primary source: ECOCYC:EG11673
Locus tag: b3058
See related: ASAP:ABE-0010036
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK3048; ygiG
Summary: The N-terminal sequence of native FolB(YgiG) is MDIVFIEQL (Jeff Green, personal comm. [More information is available at EcoGene: EG11673]. Dihydroneopterin aldolase is an enzyme in the tetrahydrofolate biosynthesis pathway, an important antibacterial drug target. [More information is available at EcoCyc: EG11673].
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NC_000913.3 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

N-terminus verified by Edman degradation on complete protein
Title: The ndh-binding protein (Nbp) regulates the ndh gene of Escherichia coli in response to growth phase and is identical to Fis.
The epimerase reaction follows a nonstereospecific retroaldol/aldol mechanism with the same reaction intermediate as that of the aldolase reaction, forming the basis for elucidating the catalytic mechanism.
Title: Mechanism of dihydroneopterin aldolase. NMR, equilibrium and transient kinetic studies of the Staphylococcus aureus and Escherichia coli enzymes.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables dihydroneopterin aldolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables dihydroneopterin aldolase activity	IDA Inferred from Direct Assay more info	PubMed
enables dihydroneopterin aldolase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in folic acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in folic acid-containing compound metabolic process	IEA Inferred from Electronic Annotation more info
involved_in tetrahydrofolate biosynthetic process	IEA Inferred from Electronic Annotation more info