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    fabZ 3-hydroxy-acyl-[acyl-carrier-protein] dehydratase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 944888, updated on 3-Dec-2024

    Summary

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    Official Symbol
    fabZ
    Official Full Name
    3-hydroxy-acyl-[acyl-carrier-protein] dehydratase
    Primary source
    ECOCYC:EG11284
    Locus tag
    b0180
    See related
    ASAP:ABE-0000613
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0179; sabA1; sefA; sfhC21; yaeA
    Summary
    Binds TrxA (Kumar, 2004). [More information is available at EcoGene: EG11284]. Certain mutations in fabZ have been found as suppressor mutations; its sabA1 allele changes the suppression of the OmpF315 phenotype by asmB1, and increased fabZ expression suppresses OmpF315 itself . [More information is available at EcoCyc: EG11284].
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    Genomic context

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    Sequence:
    NC_000913.3 (202101..202556)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene periplasmic chaperone Skp Neighboring gene UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase Neighboring gene acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase Neighboring gene lipid A disaccharide synthase Neighboring gene RNase HII

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Septum formation-defective mutant of Escherichia coli. Normark S, et al. J Bacteriol, 1976 Oct. PMID 789345, Free PMC Article
    2. An Escherichia coli gene (FabZ) encoding (3R)-hydroxymyristoyl acyl carrier protein dehydrase. Relation to fabA and suppression of mutations in lipid A biosynthesis. Mohan S, et al. J Biol Chem, 1994 Dec 30. PMID 7806516
    3. Insertion mutagenesis of the gene encoding the ferrichrome-iron receptor of Escherichia coli K-12. Carmel G, et al. J Bacteriol, 1990 Apr. PMID 2156805, Free PMC Article
    4. Induction of Escherichia coli hydroperoxidase I by acetate and other weak acids. Mukhopadhyay S, et al. J Bacteriol, 1994 Apr. PMID 8157598, Free PMC Article
    5. Molecular characterization of enterobacterial pldA genes encoding outer membrane phospholipase A. Brok RG, et al. J Bacteriol, 1994 Feb. PMID 8300539, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The fused dimer of FabZ (FabZ-FabZ) was expressed as a soluble enzyme with an ninefold higher activity in vitro than the unfused FabZ.
      Title: Fused dimerization increases expression, solubility, and activity of bacterial dehydratase enzymes.
    2. N-terminus verified by Edman degradation on complete protein
      Title: Purification and characterization of an 'actomyosin' complex from Escherichia coli W3110.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydro-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within fatty acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid A biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    3-hydroxy-acyl-[acyl-carrier-protein] dehydratase
    NP_414722.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      202101..202556
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414722.1 3-hydroxy-acyl-[acyl-carrier-protein] dehydratase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414722.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376U2X3
      Conserved Domains (1) summary
      PRK00006
      Location:2 → 150
      fabZ; 3-hydroxyacyl-ACP dehydratase FabZ
    Nucleotide Protein
    Heading Accession and Version

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