Acp3 acid phosphatase 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Acp3provided by RGD
Official Full Name: acid phosphatase 3provided by RGD
Primary source: RGD:2023
See related: EnsemblRapid:ENSRNOG00000011820 AllianceGenome:RGD:2023
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: pap; Acpp; FRAP; Ppal; 5'-NT; Acpp11; RNACPP11
Summary: Enables acid phosphatase activity; choline binding activity; and protein homodimerization activity. Involved in dephosphorylation. Located in Golgi cisterna; apical part of cell; and cytoplasmic vesicle. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human ACP3 (acid phosphatase 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 37.5), Liver (RPKM 33.9) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (113784372..113833033, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (104905570..104956146, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (112838574..112884062, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PAP-immunoreactivity was present in type I and one of type III taste cells of taste buds. Thus, it is suggested that PAP might be a responsible ectoenzyme for metabolism of extracellular nucleotides, being involved in the regulation of taste signaling in taste buds.
Title: Expression of Prostatic Acid Phosphatase in Rat Circumvallate Papillae.
Our findings suggest that the decrease of PAP in dorsal root ganglion neurons is involved in pathophysiological mechanisms of neuropathic pain
Title: Deceased expression of prostatic acid phosphatase in primary sensory neurons after peripheral nerve injury.
Acpp plays an important role in growth and development of the penis of rats, and its expression is modulated at epigenomic levels via specific miRs
Title: Dietary cholesterol affects expression of prostatic acid phosphatase in reproductive organs of male rats.
studies highlight similarities and differences in PAP localization within nociceptive neurons of mice and rats
Title: Prostatic acid phosphatase is expressed in peptidergic and nonpeptidergic nociceptive neurons of mice and rats.
analysis of prostatic acid phosphatase binding
Title: Theoretical investigations of prostatic acid phosphatase.

Submit: New GeneRIF Correction

General gene information

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Markers

BI283253 (e-PCR)
- UniSTS:243501

D8Wox15 (e-PCR)
- UniSTS:517804

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 5'-nucleotidase activity	IEA Inferred from Electronic Annotation more info
enables 5'-nucleotidase activity	ISO Inferred from Sequence Orthology more info
enables XMP 5'-nucleosidase activity	IEA Inferred from Electronic Annotation more info
enables acid phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables acid phosphatase activity	IEA Inferred from Electronic Annotation more info
enables acid phosphatase activity	ISO Inferred from Sequence Orthology more info
enables choline binding	IDA Inferred from Direct Assay more info	PubMed
enables histone H2AXY142 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lysophosphatidic acid phosphatase activity	IEA Inferred from Electronic Annotation more info
enables lysophosphatidic acid phosphatase activity	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables non-membrane spanning protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine phosphatase activity, metal-dependent	IEA Inferred from Electronic Annotation more info
enables thiamine phosphate phosphatase activity	IEA Inferred from Electronic Annotation more info
enables thiamine phosphate phosphatase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adenosine metabolic process	IEA Inferred from Electronic Annotation more info
involved_in adenosine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in dephosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in nucleotide metabolic process	IEA Inferred from Electronic Annotation more info
involved_in nucleotide metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of adenosine receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of adenosine receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of adenosine receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in purine nucleobase metabolic process	IEA Inferred from Electronic Annotation more info
involved_in purine nucleobase metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of sensory perception of pain	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of sensory perception of pain	IEA Inferred from Electronic Annotation more info
involved_in regulation of sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in thiamine metabolic process	IEA Inferred from Electronic Annotation more info
involved_in thiamine metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi cisterna	IDA Inferred from Direct Assay more info	PubMed
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in filopodium	IEA Inferred from Electronic Annotation more info
located_in filopodium	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in multivesicular body	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in secretory granule	IDA Inferred from Direct Assay more info	PubMed
located_in vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in vesicle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: prostatic acid phosphatase

Names: 5'-nucleotidase; TMPase; acid phosphatase, prostate; ecto-5'-nucleotidase; fluoride-resistant acid phosphatase; prostatic acid phosphatase (rPAP); protein tyrosine phosphatase ACP3; thiamine monophosphatase

NP_001128373.1

EC 3.1.3.2

EC 3.1.3.48

EC 3.1.3.5

NP_064457.2

EC 3.1.3.2

EC 3.1.3.48

EC 3.1.3.5

XP_038937950.1

EC 3.1.3.2

EC 3.1.3.48

EC 3.1.3.5

XP_038937951.1

EC 3.1.3.2

EC 3.1.3.48

EC 3.1.3.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001134901.3 → NP_001128373.1 prostatic acid phosphatase long isoform precursor

See identical proteins and their annotated locations for NP_001128373.1

Status: VALIDATED

Description

Transcript Variant: This variant (1), also called TM-PAP, encodes the longer isoform. This isoform is a transmembrane protein.

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A0A0G2K4B4

Related

ENSRNOP00000072975.1, ENSRNOT00000085585.3

Conserved Domains (1) summary

cd07061
Location:33 → 331

HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction
NM_020072.3 → NP_064457.2 prostatic acid phosphatase short isoform precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2), also called PAP, differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform has a shorter and distinct C-terminus compared to the longer isoform. This isoform is a secreted protein.

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

A0A0G2JSL5, A6XJQ5, P20646

Related

ENSRNOP00000016222.5, ENSRNOT00000016222.7

Conserved Domains (1) summary

cd07061
Location:33 → 331

HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

113784372..113833033 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039082022.2 → XP_038937950.1 prostatic acid phosphatase isoform X1

Conserved Domains (1) summary

cd07061
Location:1 → 258

HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction
XM_039082023.2 → XP_038937951.1 prostatic acid phosphatase isoform X1

Conserved Domains (1) summary

cd07061
Location:1 → 258

HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction