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    purL phosphoribosylformylglycinamide synthetase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947032, updated on 17-Dec-2024

    Summary

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    Official Symbol
    purL
    Official Full Name
    phosphoribosylformylglycinamide synthetase
    Primary source
    ECOCYC:EG10797
    Locus tag
    b2557
    See related
    ASAP:ABE-0008412
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2555; purI
    Summary
    Genetic complementation tests showed that the coli purL gene was divided into three domains. [More information is available at EcoCyc: EG10797].
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    Genomic context

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    Sequence:
    NC_000913.3 (2691656..2695543, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene histidine kinase GlrK Neighboring gene ncRNA Neighboring gene membrane-bound lytic murein transglycosylase F Neighboring gene tRNA adenosine(34) deaminase Neighboring gene phosphatidylglycerophosphatase C

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of the enzymatic reactions encoded by the purG and purI genes of Escherichia coli. Houlberg U, et al. J Bacteriol, 1983 Jun. PMID 6343356, Free PMC Article
    2. Formylglycinamide ribonucleotide synthetase from Escherichia coli: cloning, sequencing, overproduction, isolation, and characterization. Schendel FJ, et al. Biochemistry, 1989 Mar 21. PMID 2659070
    3. P-BOSS: a new filtering method for treasure hunting in metabolomics. Morohashi M, et al. J Chromatogr A, 2007 Aug 3. PMID 17400234
    4. Location of purine genes on the physical map of Escherichia coli. Masters M. J Bacteriol, 1990 Mar. PMID 2407714, Free PMC Article
    5. Autoregulation of PurR repressor synthesis and involvement of purR in the regulation of purB, purC, purL, purMN and guaBA expression in Escherichia coli. Meng LM, et al. Eur J Biochem, 1990 Jan 26. PMID 2404765

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on complete protein
      Title: Formylglycinamide ribonucleotide synthetase from Escherichia coli: cloning, sequencing, overproduction, isolation, and characterization.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoribosylformylglycinamidine synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphoribosylformylglycinamidine synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphoribosylformylglycinamidine synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoribosylformylglycinamidine synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within 'de novo' IMP biosynthetic process IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in 'de novo' IMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within glutamine metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in purine nucleotide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in purine nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphoribosylformylglycinamide synthetase
    YP_026170.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2691656..2695543 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_026170.1 phosphoribosylformylglycinamide synthetase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for YP_026170.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8T5ZYX3, A0AAN4NSI9
      Conserved Domains (1) summary
      PRK05297
      Location:2 → 1295
      PRK05297; phosphoribosylformylglycinamidine synthase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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