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    Hlx H2.0-like homeobox [ Mus musculus (house mouse) ]

    Gene ID: 15284, updated on 4-Jan-2025

    Summary

    Official Symbol
    Hlxprovided by MGI
    Official Full Name
    H2.0-like homeoboxprovided by MGI
    Primary source
    MGI:MGI:96109
    See related
    Ensembl:ENSMUSG00000039377 AllianceGenome:MGI:96109
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hlx1
    Summary
    Predicted to enable sequence-specific DNA binding activity. Acts upstream of or within several processes, including embryonic digestive tract morphogenesis; enteric nervous system development; and regulation of T-helper cell differentiation. Predicted to be located in nucleus. Is expressed in several structures, including branchial arch; central nervous system; embryo mesenchyme; genitourinary system; and gut. Orthologous to human HLX (H2.0 like homeobox). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in lung adult (RPKM 22.8), adrenal adult (RPKM 12.9) and 21 other tissues See more
    Orthologs
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    Genomic context

    See Hlx in Genome Data Viewer
    Location:
    1 H5; 1 88.97 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (184459340..184464690, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (184727143..184732493, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_03305 Neighboring gene ribosomal protein 21, pseudogene 1 Neighboring gene RIKEN cDNA 4930488B22 gene Neighboring gene STARR-positive B cell enhancer ABC_E2595 Neighboring gene STARR-seq mESC enhancer starr_03307 Neighboring gene predicted gene, 51725 Neighboring gene mitochondrial amidoxime reducing component 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of T-helper 1 cell differentiation PubMed 
    acts_upstream_of T-helper 1 cell differentiation PubMed 
    acts_upstream_of T-helper 2 cell differentiation PubMed 
    acts_upstream_of T-helper 2 cell differentiation PubMed 
    acts_upstream_of_or_within animal organ development PubMed 
    acts_upstream_of cell population proliferation PubMed 
    acts_upstream_of_or_within embryonic digestive tract morphogenesis PubMed 
    acts_upstream_of_or_within enteric nervous system development PubMed 
    acts_upstream_of epithelial cell proliferation PubMed 
    acts_upstream_of_or_within liver development PubMed 
    acts_upstream_of_or_within negative regulation of T-helper 2 cell differentiation PubMed 
    acts_upstream_of_or_within negative regulation of T-helper 2 cell differentiation PubMed 
    acts_upstream_of organ growth PubMed 
    acts_upstream_of_or_within positive regulation of T-helper 1 cell differentiation PubMed 
    acts_upstream_of_or_within positive regulation of T-helper 1 cell differentiation PubMed 
    acts_upstream_of_or_within positive regulation of epithelial cell proliferation PubMed 
    acts_upstream_of_or_within positive regulation of organ growth PubMed 
    involved_in regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within skeletal muscle tissue development PubMed 
    Component Evidence Code Pubs
    located_in nucleus  

    General protein information

    Preferred Names
    H2.0-like homeobox protein
    Names
    H2.0-like homeo box 1
    homeobox protein HLX1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008250.2NP_032276.1  H2.0-like homeobox protein

      See identical proteins and their annotated locations for NP_032276.1

      Status: VALIDATED

      Source sequence(s)
      AK036435, BB664380, BC050146, BC064068
      Consensus CDS
      CCDS15593.1
      UniProtKB/Swiss-Prot
      Q61670
      UniProtKB/TrEMBL
      Q549B7, Q6P3B7
      Related
      ENSMUSP00000040505.7, ENSMUST00000048572.7
      Conserved Domains (2) summary
      COG5576
      Location:224341
      COG5576; Homeodomain-containing transcription factor [Transcription]
      pfam00046
      Location:276329
      Homeobox; Homeobox domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      184459340..184464690 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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