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    shiA shikimate:H(+) symporter [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946495, updated on 3-Dec-2024

    Summary

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    Official Symbol
    shiA
    Official Full Name
    shikimate:H(+) symporter
    Primary source
    ECOCYC:G7067
    Locus tag
    b1981
    See related
    ASAP:ABE-0006572
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1976; yeeM
    Summary
    Major Facilitator Superfamily (MFS). [More information is available at EcoGene: EG20205]. ShiA has been implicated in the high affinity transport of shikimate, an intermediate in the aromatic amino acid biosynthetic pathway . [More information is available at EcoCyc: G7067].
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    Genomic context

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    Sequence:
    NC_000913.3 (2053643..2054959)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene inverse autotransporter adhesin Neighboring gene pseudo Neighboring gene AMP nucleosidase Neighboring gene putative transcriptional regulator YeeN

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Gene controlling the uptake of shikimic acid by Escherichia coli. Pittard J, et al. J Bacteriol, 1966 Oct. PMID 5332864, Free PMC Article
    2. Cloning and analysis of the shiA gene, which encodes the shikimate transport system of escherichia coli K-12. Whipp MJ, et al. Gene, 1998 Mar 16. PMID 9524262
    3. Frequency and mechanism of resistance to antibacterial action of ZM 240401, (6S)-6-fluoro-shikimic acid. Ewart CD, et al. Antimicrob Agents Chemother, 1995 Jan. PMID 7695335, Free PMC Article
    4. Transport and utilization of the biosynthetic intermediate shikimic acid in Escherichia coli. Brown KD, et al. Biochim Biophys Acta, 1976 May 28. PMID 6050
    5. Hydroaromatic equilibration during biosynthesis of shikimic acid. Knop DR, et al. J Am Chem Soc, 2001 Oct 24. PMID 11603966

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables shikimate transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within shikimate transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    shikimate:H(+) symporter

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2053643..2054959
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416488.1 shikimate:H(+) symporter [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416488.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376D8Z8
      Conserved Domains (1) summary
      PRK09952
      Location:1 → 438
      PRK09952; shikimate transporter; Provisional
    Nucleotide Protein
    Heading Accession and Version

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