hisD histidinal/histidinol dehydrogenase [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

Official Symbol: hisD
Official Full Name: histidinal/histidinol dehydrogenase
Primary source: ECOCYC:EG10447
Locus tag: b2020
See related: ASAP:ABE-0006715
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK2015
Summary: The bifunctional histidinol / histidinal dehydrogenase (HisD) carries out the final two steps in histidine biosynthesis. [More information is available at EcoCyc: EG10447].
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NC_000913.3 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

N-terminus verified by Edman degradation on mature peptide
Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables histidinol dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histidinol dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed
enables histidinol dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables manganese ion binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-histidine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within L-histidine biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in L-histidine biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed

NP_416524.1

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The following sections contain reference sequences that belong to a specific genome build. Explain