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    iadA isoaspartyl dipeptidase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948853, updated on 3-Dec-2024

    Summary

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    Official Symbol
    iadA
    Official Full Name
    isoaspartyl dipeptidase
    Primary source
    ECOCYC:G7925
    Locus tag
    b4328
    See related
    ASAP:ABE-0014195
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4319; yjiF
    Summary
    Isoaspartyl dipeptidase is a peptidase that breaks down linkages, the peptide bonds that can form spontaneously between the side chain of an aspartate residue and another amino acid . [More information is available at EcoCyc: G7925].
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    Genomic context

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    Sequence:
    NC_000913.3 (4558354..4559526, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene iraD leader peptide Neighboring gene anti-adaptor protein IraD Neighboring gene DNA-binding transcriptional dual regulator HypT Neighboring gene Gate family protein YjiG Neighboring gene uncharacterized protein YjiH Neighboring gene RNA 2'-phosphotransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mechanism of the reaction catalyzed by isoaspartyl dipeptidase from Escherichia coli. Martí-Arbona R, et al. Biochemistry, 2005 May 17. PMID 15882050
    2. X-ray structure of isoaspartyl dipeptidase from E.coli: a dinuclear zinc peptidase evolved from amidohydrolases. Jozic D, et al. J Mol Biol, 2003 Sep 5. PMID 12946361
    3. High-resolution X-ray structure of isoaspartyl dipeptidase from Escherichia coli. Thoden JB, et al. Biochemistry, 2003 May 6. PMID 12718528
    4. Purification and properties of a beta-aspartyl peptidase from Escherichia coli. Haley EE. J Biol Chem, 1968 Nov 10. PMID 4880759
    5. Purification and characterization of an isoaspartyl dipeptidase from Escherichia coli. Gary JD, et al. J Biol Chem, 1995 Feb 24. PMID 7876157

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on complete protein
      Title: Purification and characterization of an isoaspartyl dipeptidase from Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables beta-aspartyl-peptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables beta-aspartyl-peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    isoaspartyl dipeptidase
    NP_418748.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4558354..4559526 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418748.1 isoaspartyl dipeptidase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418748.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376X946
      Conserved Domains (1) summary
      TIGR01975
      Location:9 → 388
      isoAsp_dipep; isoaspartyl dipeptidase IadA
    Nucleotide Protein
    Heading Accession and Version

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