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    pdxY pyridoxal kinase 2 [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946162, updated on 17-Dec-2024

    Summary

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    Official Symbol
    pdxY
    Official Full Name
    pyridoxal kinase 2
    Primary source
    ECOCYC:G6879
    Locus tag
    b1636
    See related
    ASAP:ABE-0005475
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1632; ydgS
    Summary
    Involved in the salvage pathway of pyridoxal 5'-phosphate biosynthesis. [More information is available at EcoGene: EG13940].
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    Genomic context

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    Sequence:
    NC_000913.3 (1715026..1715889, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene dipeptide/tripeptide:H(+) symporter DtpA Neighboring gene glutathione S-transferase GstA Neighboring gene tyrosine--tRNA ligase Neighboring gene pyridoxine/pyridoxamine 5'-phosphate oxidase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tailored Cofactor Traps for the in Situ Detection of Hemithioacetal-Forming Pyridoxal Kinases. Hübner I, et al. ACS Chem Biol, 2020 Dec 18. PMID 33269909
    2. Crystal structure of the PdxY Protein from Escherichia coli. Safo MK, et al. J Bacteriol, 2004 Dec. PMID 15547280, Free PMC Article
    3. Expression, purification, and kinetic constants for human and Escherichia coli pyridoxal kinases. di Salvo ML, et al. Protein Expr Purif, 2004 Aug. PMID 15249053
    4. Identification and function of the pdxY gene, which encodes a novel pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate biosynthesis in Escherichia coli K-12. Yang Y, et al. J Bacteriol, 1998 Apr. PMID 9537380, Free PMC Article
    5. Structural analysis of a set of proteins resulting from a bacterial genomics project. Badger J, et al. Proteins, 2005 Sep 1. PMID 16021622

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pyridoxal kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyridoxal kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pyridoxal kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyridoxal kinase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in pyridoxal 5'-phosphate salvage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pyridoxal 5'-phosphate salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pyridoxal 5'-phosphate salvage IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within pyridoxal 5'-phosphate salvage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pyridoxal metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within vitamin B6 biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vitamin B6 metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pyridoxal kinase 2
    NP_416153.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1715026..1715889 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416153.1 pyridoxal kinase 2 [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416153.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q7ADK6, Q8X649
      UniProtKB/TrEMBL
      A0A0H3MKC7, A0A1X3IYQ3, A0A2A2XRM4, A0A7H9S9W1, A0A829L180, B7NB90, C3T8S2, D3GUD1
      Conserved Domains (1) summary
      PRK05756
      Location:2 → 287
      PRK05756; pyridoxal kinase PdxY
    Nucleotide Protein
    Heading Accession and Version

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