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    flhB flagellar biosynthesis protein FlhB [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946391, updated on 3-Dec-2024

    Summary

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    Official Symbol
    flhB
    Official Full Name
    flagellar biosynthesis protein FlhB
    Primary source
    ECOCYC:G7028
    Locus tag
    b1880
    See related
    ASAP:ABE-0006275
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1881; flaG; yecQ
    Summary
    Autocleavage of C-terminal domain regulates early-late flagellar protein export switch in Salmonella and Escherichia coli; the cleaved domain (270-383 aa)remains tightly bound (Minamino, 2000; Ferris, 2005). [More information is available at EcoGene: EG14035]. FlhB is one of six integral membrane components of the flagellar export apparatus. [More information is available at EcoCyc: G7028].
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    Genomic context

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    Sequence:
    NC_000913.3 (1965043..1966191, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene protein YecT Neighboring gene flagellar protein FlhE Neighboring gene flagellar biosynthesis protein FlhA Neighboring gene chemotaxis protein CheZ Neighboring gene chemotaxis protein CheY

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural analysis of the essential self-cleaving type III secretion proteins EscU and SpaS. Zarivach R, et al. Nature, 2008 May 1. PMID 18451864
    2. Substrate specificity of type III flagellar protein export in Salmonella is controlled by subdomain interactions in FlhB. Fraser GM, et al. Mol Microbiol, 2003 May. PMID 12753195
    3. Multiple factors underlying the maximum motility of Escherichia coli as cultures enter post-exponential growth. Amsler CD, et al. J Bacteriol, 1993 Oct. PMID 8407796, Free PMC Article
    4. FliK-Driven Conformational Rearrangements of FlhA and FlhB Are Required for Export Switching of the Flagellar Protein Export Apparatus. Minamino T, et al. J Bacteriol, 2020 Jan 15. PMID 31712281, Free PMC Article
    5. Increased motility of Escherichia coli by insertion sequence element integration into the regulatory region of the flhD operon. Barker CS, et al. J Bacteriol, 2004 Nov. PMID 15516564, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FliK-Driven Conformational Rearrangements of FlhA and FlhB Are Required for Export Switching of the Flagellar Protein Export Apparatus.
      Title: FliK-Driven Conformational Rearrangements of FlhA and FlhB Are Required for Export Switching of the Flagellar Protein Export Apparatus.
    2. FlhB cleavage is an autocatalytic process
      Title: FlhB regulates ordered export of flagellar components via autocleavage mechanism.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Process Evidence Code Pubs
    involved_in bacterial-type flagellum assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in bacterial-type flagellum organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in bacterial-type flagellum-dependent cell motility NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in chemotaxis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in protein secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein secretion by the type III secretion system NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in bacterial-type flagellum NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in bacterial-type flagellum secretion apparatus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of type III protein secretion system complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    flagellar biosynthesis protein FlhB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1965043..1966191 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416394.1 flagellar biosynthesis protein FlhB [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416394.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7XLS0
      Conserved Domains (1) summary
      cl19167
      Location:1 → 380
      Bac_export_2; FlhB HrpN YscU SpaS Family
    Nucleotide Protein
    Heading Accession and Version

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