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    Kmt2d lysine (K)-specific methyltransferase 2D [ Mus musculus (house mouse) ]

    Gene ID: 381022, updated on 24-Dec-2024

    Summary

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    Official Symbol
    Kmt2dprovided by MGI
    Official Full Name
    lysine (K)-specific methyltransferase 2Dprovided by MGI
    Primary source
    MGI:MGI:2682319
    See related
    Ensembl:ENSMUSG00000048154 AllianceGenome:MGI:2682319
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ALR; Mll2; Mll4; bapa; KMT2B; C430014K11Rik
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific and histone H3K4 methyltransferase activity. Involved in heterochromatin formation and oocyte growth. Acts upstream of or within in utero embryonic development and regulation of gene expression. Predicted to be located in nucleoplasm. Predicted to be part of MLL3/4 complex. Is expressed in several structures, including central nervous system; cranium; heart; integumental system; and sensory organ. Used to study Kabuki syndrome. Human ortholog(s) of this gene implicated in Kabuki syndrome; carcinoma (multiple); and intracranial aneurysm. Orthologous to human KMT2D (lysine methyltransferase 2D). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 25.1), spleen adult (RPKM 21.8) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Kmt2d in Genome Data Viewer
    Location:
    15 F1; 15
    Exon count:
    57
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (98729550..98771958, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (98831669..98874077, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene dendrin Neighboring gene protein kinase, AMP-activated, gamma 1 non-catalytic subunit Neighboring gene STARR-positive B cell enhancer ABC_E1918 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:98663163-98663346 Neighboring gene STARR-seq mESC enhancer starr_39676 Neighboring gene STARR-positive B cell enhancer ABC_E10880 Neighboring gene Ras homolog enriched in brain like 1 Neighboring gene desert hedgehog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Histone deacetylase inhibition rescues structural and functional brain deficits in a mouse model of Kabuki syndrome. Bjornsson HT, et al. Sci Transl Med, 2014 Oct 1. PMID 25273096, Free PMC Article
    2. Mutation of cancer driver MLL2 results in transcription stress and genome instability. Kantidakis T, et al. Genes Dev, 2016 Feb 15. PMID 26883360, Free PMC Article
    3. PLD2 deletion ameliorates sepsis-induced cardiomyopathy by suppressing cardiomyocyte pyroptosis via the NLRP3/caspase 1/GSDMD pathway. Li J, et al. Inflamm Res, 2024 Jun. PMID 38630134, Free PMC Article
    4. MLL2 conveys transcription-independent H3K4 trimethylation in oocytes. Hanna CW, et al. Nat Struct Mol Biol, 2018 Jan. PMID 29323282
    5. MLL4 Is Required to Maintain Broad H3K4me3 Peaks and Super-Enhancers at Tumor Suppressor Genes. Dhar SS, et al. Mol Cell, 2018 Jun 7. PMID 29861161, Free PMC Article

    See all (109) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Histone-methyltransferase KMT2D deficiency impairs the Fanconi anemia/BRCA pathway upon glycolytic inhibition in squamous cell carcinoma.
      Title: Histone-methyltransferase KMT2D deficiency impairs the Fanconi anemia/BRCA pathway upon glycolytic inhibition in squamous cell carcinoma.
    2. KMT2D regulates activation, localization, and integrin expression by T-cells.
      Title: KMT2D regulates activation, localization, and integrin expression by T-cells.
    3. Histone methyltransferase MLL4 protects against pressure overload-induced heart failure via a THBS4-mediated protection in ER stress.
      Title: Histone methyltransferase MLL4 protects against pressure overload-induced heart failure via a THBS4-mediated protection in ER stress.
    4. PLD2 deletion ameliorates sepsis-induced cardiomyopathy by suppressing cardiomyocyte pyroptosis via the NLRP3/caspase 1/GSDMD pathway.
      Title: PLD2 deletion ameliorates sepsis-induced cardiomyopathy by suppressing cardiomyocyte pyroptosis via the NLRP3/caspase 1/GSDMD pathway.
    5. Loss of CREBBP and KMT2D cooperate to accelerate lymphomagenesis and shape the lymphoma immune microenvironment.
      Title: Loss of CREBBP and KMT2D cooperate to accelerate lymphomagenesis and shape the lymphoma immune microenvironment.
    6. KMT2D Deficiency Causes Sensorineural Hearing Loss in Mice and Humans.
      Title: KMT2D Deficiency Causes Sensorineural Hearing Loss in Mice and Humans.
    7. Loss of Histone Methyltransferase KMT2D Attenuates Angiogenesis in the Ischemic Heart by Inhibiting the Transcriptional Activation of VEGF-A.
      Title: Loss of Histone Methyltransferase KMT2D Attenuates Angiogenesis in the Ischemic Heart by Inhibiting the Transcriptional Activation of VEGF-A.
    8. MLL3/MLL4 methyltransferase activities control early embryonic development and embryonic stem cell differentiation in a lineage-selective manner.
      Title: MLL3/MLL4 methyltransferase activities control early embryonic development and embryonic stem cell differentiation in a lineage-selective manner.
    9. Loss of MLL3/4 decouples enhancer H3K4 monomethylation, H3K27 acetylation, and gene activation during embryonic stem cell differentiation.
      Title: Loss of MLL3/4 decouples enhancer H3K4 monomethylation, H3K27 acetylation, and gene activation during embryonic stem cell differentiation.
    10. KMT2D Deficiency Promotes Myeloid Leukemias which Is Vulnerable to Ribosome Biogenesis Inhibition.
      Title: KMT2D Deficiency Promotes Myeloid Leukemias which Is Vulnerable to Ribosome Biogenesis Inhibition.
    Submit: New GeneRIF Correction See all GeneRIFs (60)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone H3K4 methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H3K4 methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables histone H3K4 monomethyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K4 trimethyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oocyte growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of intracellular estrogen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to estrogen ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of MLL3/4 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MLL3/4 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of histone methyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    histone-lysine N-methyltransferase 2D
    Names
    ALL1-related protein
    histone-lysine N-methyltransferase MLL2
    lysine N-methyltransferase 2B
    lysine N-methyltransferase 2D
    myeloid/lymphoid or mixed-lineage leukemia 2
    myeloid/lymphoid or mixed-lineage leukemia protein 2
    NP_001028448.3
    XP_017172163.1
    XP_017172164.1
    XP_017172165.1
    XP_017172166.1
    XP_017172167.1
    XP_017172168.1
    XP_017172169.1
    XP_017172170.1
    XP_017172171.1
    XP_017172172.1
    XP_017172173.1
    XP_030104483.1
    XP_030104484.1
    XP_036015372.1
    XP_036015373.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033276.3 → NP_001028448.3  histone-lysine N-methyltransferase 2D

      Status: VALIDATED

      Source sequence(s)
      AC161165
      Consensus CDS
      CCDS49725.2
      UniProtKB/Swiss-Prot
      Q6PDK2
      UniProtKB/TrEMBL
      A0A0A0MQ73
      Related
      ENSMUSP00000023741.9, ENSMUST00000023741.16
      Conserved Domains (11) summary
      smart00398
      Location:1978 → 2029
      HMG; high mobility group
      smart00542
      Location:5291 → 5378
      FYRC; FY-rich domain, C-terminal region
      smart00317
      Location:5448 → 5570
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      cd15509
      Location:228 → 273
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15513
      Location:1385 → 1431
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15597
      Location:1334 → 1384
      PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15601
      Location:1462 → 1512
      PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15695
      Location:134 → 217
      ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
      cd15698
      Location:5083 → 5189
      ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
      pfam05964
      Location:5233 → 5283
      FYRN; F/Y-rich N-terminus
      cl22851
      Location:275 → 320
      PHD_SF; PHD finger superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      98729550..98771958 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316684.2 → XP_017172173.1  histone-lysine N-methyltransferase 2D isoform X15

      UniProtKB/Swiss-Prot
      Q6PDK2
      Conserved Domains (12) summary
      smart00398
      Location:1979 → 2030
      HMG; high mobility group
      smart00542
      Location:5292 → 5379
      FYRC; FY-rich domain, C-terminal region
      PHA03247
      Location:2068 → 2634
      PHA03247; large tegument protein UL36; Provisional
      cd15509
      Location:228 → 273
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15513
      Location:1386 → 1432
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15597
      Location:1335 → 1385
      PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15601
      Location:1463 → 1513
      PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15695
      Location:134 → 217
      ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
      cd15698
      Location:5084 → 5190
      ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
      pfam05964
      Location:5233 → 5284
      FYRN; F/Y-rich N-terminus
      cd19209
      Location:5434 → 5588
      SET_KMT2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins
      cl22851
      Location:275 → 320
      PHD_SF; PHD finger superfamily

    2. XM_017316674.2 → XP_017172163.1  histone-lysine N-methyltransferase 2D isoform X1

      UniProtKB/Swiss-Prot
      Q6PDK2
      Conserved Domains (12) summary
      smart00398
      Location:1982 → 2033
      HMG; high mobility group
      smart00542
      Location:5295 → 5382
      FYRC; FY-rich domain, C-terminal region
      PHA03247
      Location:2071 → 2637
      PHA03247; large tegument protein UL36; Provisional
      cd15509
      Location:228 → 273
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15513
      Location:1386 → 1432
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15597
      Location:1335 → 1385
      PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15601
      Location:1463 → 1513
      PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15695
      Location:134 → 217
      ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
      cd15698
      Location:5087 → 5193
      ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
      pfam05964
      Location:5236 → 5287
      FYRN; F/Y-rich N-terminus
      cd19209
      Location:5453 → 5607
      SET_KMT2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins
      cl22851
      Location:275 → 320
      PHD_SF; PHD finger superfamily

    3. XM_017316680.2 → XP_017172169.1  histone-lysine N-methyltransferase 2D isoform X9

      UniProtKB/Swiss-Prot
      Q6PDK2
      Conserved Domains (12) summary
      smart00398
      Location:1976 → 2027
      HMG; high mobility group
      smart00542
      Location:5289 → 5376
      FYRC; FY-rich domain, C-terminal region
      PHA03247
      Location:2065 → 2631
      PHA03247; large tegument protein UL36; Provisional
      cd15509
      Location:228 → 273
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15513
      Location:1385 → 1431
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15597
      Location:1334 → 1384
      PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15601
      Location:1462 → 1512
      PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15695
      Location:134 → 217
      ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
      cd15698
      Location:5081 → 5187
      ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
      pfam05964
      Location:5230 → 5281
      FYRN; F/Y-rich N-terminus
      cd19209
      Location:5447 → 5601
      SET_KMT2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins
      cl22851
      Location:275 → 320
      PHD_SF; PHD finger superfamily

    4. XM_030248623.1 → XP_030104483.1  histone-lysine N-methyltransferase 2D isoform X7

      UniProtKB/Swiss-Prot
      Q6PDK2
      Conserved Domains (12) summary
      smart00398
      Location:1978 → 2029
      HMG; high mobility group
      smart00542
      Location:5291 → 5378
      FYRC; FY-rich domain, C-terminal region
      PHA03247
      Location:2067 → 2633
      PHA03247; large tegument protein UL36; Provisional
      cd15509
      Location:228 → 273
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15513
      Location:1385 → 1431
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15597
      Location:1334 → 1384
      PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15601
      Location:1462 → 1512
      PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15695
      Location:134 → 217
      ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
      cd15698
      Location:5083 → 5189
      ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
      pfam05964
      Location:5232 → 5283
      FYRN; F/Y-rich N-terminus
      cd19209
      Location:5449 → 5603
      SET_KMT2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins
      cl22851
      Location:275 → 320
      PHD_SF; PHD finger superfamily

    5. XM_017316675.2 → XP_017172164.1  histone-lysine N-methyltransferase 2D isoform X2

      UniProtKB/Swiss-Prot
      Q6PDK2
      Conserved Domains (12) summary
      smart00398
      Location:1981 → 2032
      HMG; high mobility group
      smart00542
      Location:5294 → 5381
      FYRC; FY-rich domain, C-terminal region
      PHA03247
      Location:2070 → 2636
      PHA03247; large tegument protein UL36; Provisional
      cd15509
      Location:228 → 273
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15513
      Location:1385 → 1431
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15597
      Location:1334 → 1384
      PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15601
      Location:1462 → 1512
      PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15695
      Location:134 → 217
      ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
      cd15698
      Location:5086 → 5192
      ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
      pfam05964
      Location:5235 → 5286
      FYRN; F/Y-rich N-terminus
      cd19209
      Location:5452 → 5606
      SET_KMT2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins
      cl22851
      Location:275 → 320
      PHD_SF; PHD finger superfamily

    6. XM_036159479.1 → XP_036015372.1  histone-lysine N-methyltransferase 2D isoform X12

      UniProtKB/Swiss-Prot
      Q6PDK2
      Conserved Domains (12) summary
      smart00398
      Location:1908 → 1959
      HMG; high mobility group
      smart00542
      Location:5221 → 5308
      FYRC; FY-rich domain, C-terminal region
      PHA03247
      Location:1997 → 2563
      PHA03247; large tegument protein UL36; Provisional
      cd15509
      Location:228 → 273
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15513
      Location:1386 → 1432
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15597
      Location:1335 → 1385
      PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15601
      Location:1463 → 1513
      PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15695
      Location:134 → 217
      ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
      cd15698
      Location:5013 → 5119
      ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
      cd19209
      Location:5379 → 5533
      SET_KMT2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins
      pfam05964
      Location:5162 → 5213
      FYRN; F/Y-rich N-terminus
      cl22851
      Location:275 → 320
      PHD_SF; PHD finger superfamily

    7. XM_030248624.1 → XP_030104484.1  histone-lysine N-methyltransferase 2D isoform X8

      UniProtKB/Swiss-Prot
      Q6PDK2
      Conserved Domains (12) summary
      smart00398
      Location:1977 → 2028
      HMG; high mobility group
      smart00542
      Location:5290 → 5377
      FYRC; FY-rich domain, C-terminal region
      PHA03247
      Location:2066 → 2632
      PHA03247; large tegument protein UL36; Provisional
      cd15509
      Location:228 → 273
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15513
      Location:1386 → 1432
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15597
      Location:1335 → 1385
      PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15601
      Location:1463 → 1513
      PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15695
      Location:134 → 217
      ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
      cd15698
      Location:5082 → 5188
      ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
      pfam05964
      Location:5231 → 5282
      FYRN; F/Y-rich N-terminus
      cd19209
      Location:5448 → 5602
      SET_KMT2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins
      cl22851
      Location:275 → 320
      PHD_SF; PHD finger superfamily

    8. XM_017316678.2 → XP_017172167.1  histone-lysine N-methyltransferase 2D isoform X5

      UniProtKB/Swiss-Prot
      Q6PDK2
      Conserved Domains (12) summary
      smart00398
      Location:1980 → 2031
      HMG; high mobility group
      smart00542
      Location:5293 → 5380
      FYRC; FY-rich domain, C-terminal region
      PHA03247
      Location:2069 → 2635
      PHA03247; large tegument protein UL36; Provisional
      cd15509
      Location:228 → 273
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15513
      Location:1386 → 1432
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15597
      Location:1335 → 1385
      PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15601
      Location:1463 → 1513
      PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15695
      Location:134 → 217
      ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
      cd15698
      Location:5085 → 5191
      ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
      pfam05964
      Location:5234 → 5285
      FYRN; F/Y-rich N-terminus
      cd19209
      Location:5451 → 5605
      SET_KMT2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins
      cl22851
      Location:275 → 320
      PHD_SF; PHD finger superfamily

    9. XM_017316679.2 → XP_017172168.1  histone-lysine N-methyltransferase 2D isoform X6

      UniProtKB/Swiss-Prot
      Q6PDK2
      Conserved Domains (12) summary
      smart00398
      Location:1979 → 2030
      HMG; high mobility group
      smart00542
      Location:5292 → 5379
      FYRC; FY-rich domain, C-terminal region
      PHA03247
      Location:2068 → 2634
      PHA03247; large tegument protein UL36; Provisional
      cd15509
      Location:228 → 273
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15513
      Location:1386 → 1432
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15597
      Location:1335 → 1385
      PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15601
      Location:1463 → 1513
      PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15695
      Location:134 → 217
      ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
      cd15698
      Location:5084 → 5190
      ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
      pfam05964
      Location:5233 → 5284
      FYRN; F/Y-rich N-terminus
      cd19209
      Location:5450 → 5604
      SET_KMT2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins
      cl22851
      Location:275 → 320
      PHD_SF; PHD finger superfamily

    10. XM_017316681.2 → XP_017172170.1  histone-lysine N-methyltransferase 2D isoform X10

      UniProtKB/Swiss-Prot
      Q6PDK2
      Conserved Domains (12) summary
      smart00398
      Location:1975 → 2026
      HMG; high mobility group
      smart00542
      Location:5288 → 5375
      FYRC; FY-rich domain, C-terminal region
      PHA03247
      Location:2064 → 2630
      PHA03247; large tegument protein UL36; Provisional
      cd15509
      Location:228 → 273
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15513
      Location:1386 → 1432
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15597
      Location:1335 → 1385
      PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15601
      Location:1463 → 1513
      PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15695
      Location:134 → 217
      ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
      cd15698
      Location:5080 → 5186
      ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
      pfam05964
      Location:5229 → 5280
      FYRN; F/Y-rich N-terminus
      cd19209
      Location:5446 → 5600
      SET_KMT2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins
      cl22851
      Location:275 → 320
      PHD_SF; PHD finger superfamily

    11. XM_017316677.2 → XP_017172166.1  histone-lysine N-methyltransferase 2D isoform X4

      UniProtKB/Swiss-Prot
      Q6PDK2
      Conserved Domains (12) summary
      smart00398
      Location:1982 → 2033
      HMG; high mobility group
      smart00542
      Location:5294 → 5381
      FYRC; FY-rich domain, C-terminal region
      PHA03247
      Location:2070 → 2636
      PHA03247; large tegument protein UL36; Provisional
      cd15509
      Location:228 → 273
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15513
      Location:1386 → 1432
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15597
      Location:1335 → 1385
      PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15601
      Location:1463 → 1513
      PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15695
      Location:134 → 217
      ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
      cd15698
      Location:5086 → 5192
      ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
      pfam05964
      Location:5235 → 5286
      FYRN; F/Y-rich N-terminus
      cd19209
      Location:5452 → 5606
      SET_KMT2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins
      cl22851
      Location:275 → 320
      PHD_SF; PHD finger superfamily

    12. XM_017316682.2 → XP_017172171.1  histone-lysine N-methyltransferase 2D isoform X11

      UniProtKB/Swiss-Prot
      Q6PDK2
      Conserved Domains (12) summary
      smart00398
      Location:1982 → 2033
      HMG; high mobility group
      smart00542
      Location:5295 → 5382
      FYRC; FY-rich domain, C-terminal region
      PHA03247
      Location:2071 → 2637
      PHA03247; large tegument protein UL36; Provisional
      cd15509
      Location:228 → 273
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15513
      Location:1386 → 1432
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15597
      Location:1335 → 1385
      PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15601
      Location:1463 → 1513
      PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15695
      Location:134 → 217
      ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
      cd15698
      Location:5087 → 5193
      ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
      pfam05964
      Location:5236 → 5287
      FYRN; F/Y-rich N-terminus
      cd19209
      Location:5437 → 5591
      SET_KMT2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins
      cl22851
      Location:275 → 320
      PHD_SF; PHD finger superfamily

    13. XM_017316676.2 → XP_017172165.1  histone-lysine N-methyltransferase 2D isoform X3

      UniProtKB/Swiss-Prot
      Q6PDK2
      Conserved Domains (12) summary
      smart00398
      Location:1981 → 2032
      HMG; high mobility group
      smart00542
      Location:5294 → 5381
      FYRC; FY-rich domain, C-terminal region
      PHA03247
      Location:2070 → 2636
      PHA03247; large tegument protein UL36; Provisional
      cd15509
      Location:227 → 272
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15513
      Location:1385 → 1431
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15597
      Location:1334 → 1384
      PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15601
      Location:1462 → 1512
      PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15695
      Location:133 → 216
      ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
      cd15698
      Location:5086 → 5192
      ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
      pfam05964
      Location:5235 → 5286
      FYRN; F/Y-rich N-terminus
      cd19209
      Location:5452 → 5606
      SET_KMT2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins
      cl22851
      Location:274 → 319
      PHD_SF; PHD finger superfamily

    14. XM_036159480.1 → XP_036015373.1  histone-lysine N-methyltransferase 2D isoform X14

      Conserved Domains (6) summary
      smart00398
      Location:356 → 407
      HMG; high mobility group
      smart00542
      Location:3669 → 3756
      FYRC; FY-rich domain, C-terminal region
      PHA03247
      Location:445 → 1011
      PHA03247; large tegument protein UL36; Provisional
      cd15698
      Location:3461 → 3567
      ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
      cd19209
      Location:3827 → 3981
      SET_KMT2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins
      pfam05964
      Location:3610 → 3661
      FYRN; F/Y-rich N-terminus

    15. XM_017316683.3 → XP_017172172.1  histone-lysine N-methyltransferase 2D isoform X13

      UniProtKB/Swiss-Prot
      Q6PDK2
      Conserved Domains (8) summary
      smart00398
      Location:1982 → 2033
      HMG; high mobility group
      PHA03247
      Location:2071 → 2637
      PHA03247; large tegument protein UL36; Provisional
      cd15509
      Location:228 → 273
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15513
      Location:1386 → 1432
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15597
      Location:1335 → 1385
      PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15601
      Location:1463 → 1513
      PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15695
      Location:134 → 217
      ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
      cl22851
      Location:275 → 320
      PHD_SF; PHD finger superfamily

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001033388.1: Suppressed sequence

      Description
      NM_001033388.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PDK2.2 GenPept UniProtKB/Swiss-Prot:Q6PDK2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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