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    Opn4 opsin 4 (melanopsin) [ Mus musculus (house mouse) ]

    Gene ID: 30044, updated on 13-Jan-2025

    Summary

    Official Symbol
    Opn4provided by MGI
    Official Full Name
    opsin 4 (melanopsin)provided by MGI
    Primary source
    MGI:MGI:1353425
    See related
    Ensembl:ENSMUSG00000021799 AllianceGenome:MGI:1353425
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm533; 1110007J02Rik
    Summary
    Enables G protein-coupled photoreceptor activity. Involved in several processes, including hyaloid vascular plexus regression; optokinetic behavior; and phototransduction. Acts upstream of or within detection of temperature stimulus involved in thermoception; retina development in camera-type eye; and thermotaxis. Located in sperm head plasma membrane. Is expressed in eye and future brain. Orthologous to human OPN4 (opsin 4). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in heart adult (RPKM 1.8), thymus adult (RPKM 0.2) and 3 other tissues See more
    Orthologs
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    Genomic context

    See Opn4 in Genome Data Viewer
    Location:
    14 B; 14 20.83 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (34312575..34322099, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (34590618..34600142, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9230112D13 gene Neighboring gene STARR-seq mESC enhancer starr_36382 Neighboring gene STARR-seq mESC enhancer starr_36385 Neighboring gene LIM domain binding 3 Neighboring gene STARR-seq mESC enhancer starr_36389 Neighboring gene predicted gene, 52113 Neighboring gene STARR-seq mESC enhancer starr_36391 Neighboring gene STARR-seq mESC enhancer starr_36394 Neighboring gene RIKEN cDNA 5830448L01 gene Neighboring gene WAPL cohesin release factor

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 11-cis retinal binding  
    enables 11-cis retinal binding  
    enables G protein-coupled photoreceptor activity  
    enables G protein-coupled photoreceptor activity PubMed 
    enables G protein-coupled photoreceptor activity  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway  
    involved_in G protein-coupled receptor signaling pathway  
    involved_in cellular response to light stimulus  
    acts_upstream_of_or_within detection of temperature stimulus involved in thermoception PubMed 
    involved_in detection of visible light  
    involved_in hyaloid vascular plexus regression PubMed 
    involved_in optokinetic behavior PubMed 
    involved_in phototransduction  
    involved_in phototransduction PubMed 
    involved_in phototransduction  
    involved_in regulation of circadian rhythm PubMed 
    acts_upstream_of_or_within retina development in camera-type eye PubMed 
    involved_in rhythmic process  
    acts_upstream_of_or_within thermotaxis PubMed 
    involved_in visual perception  
    Component Evidence Code Pubs
    located_in axon  
    located_in dendrite  
    located_in membrane PubMed 
    located_in perikaryon  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in sperm head plasma membrane PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001128599.1NP_001122071.1  melanopsin isoform 2

      See identical proteins and their annotated locations for NP_001122071.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes an alternate exon in the 3' coding region and 3' UTR. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC114543
      Consensus CDS
      CCDS49446.1
      UniProtKB/Swiss-Prot
      Q9QXZ9
      Related
      ENSMUSP00000126136.2, ENSMUST00000168444.9
      Conserved Domains (2) summary
      pfam00001
      Location:86347
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:77244
      7tm_4; Olfactory receptor
    2. NM_013887.2NP_038915.1  melanopsin isoform 1

      See identical proteins and their annotated locations for NP_038915.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (1).
      Source sequence(s)
      AC114543
      Consensus CDS
      CCDS26943.1
      UniProtKB/Swiss-Prot
      A4QPG3, B2C712, Q9QXZ9
      Related
      ENSMUSP00000022331.3, ENSMUST00000022331.3
      Conserved Domains (2) summary
      pfam00001
      Location:86347
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:77244
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      34312575..34322099 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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