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    uxaA D-altronate dehydratase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947603, updated on 3-Dec-2024

    Summary

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    Official Symbol
    uxaA
    Official Full Name
    D-altronate dehydratase
    Primary source
    ECOCYC:EG12734
    Locus tag
    b3091
    See related
    ASAP:ABE-0010164
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3082; ygjW
    Summary
    ExuR regulon. [More information is available at EcoGene: EG12734]. Altronate dehydratase catalyzes the final reaction of the galaturonate branch of the hexuronate degradation pathway . [More information is available at EcoCyc: EG12734].
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    Genomic context

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    Sequence:
    NC_000913.3 (3241827..3243314, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene serine/threonine:Na(+) symporter Neighboring gene inner membrane protein Neighboring gene D-glucoronate/D-galacturonate isomerase Neighboring gene hexuronate transporter

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Uronic acid metabolism in bacteria. III. Purification and properties of D-altronic acid and D-mannonic acid dehydrases in Escherichia coli. SMILEY JD, et al. J Biol Chem, 1960 Jun. PMID 13831814
    2. D-Mannonate and D-altronate dehydratases of Escherichia coli K12. Robert-Baudouy J, et al. Methods Enzymol, 1982. PMID 6759855
    3. The gene for ribosomal protein S21, rpsU, maps close to dnaG at 66.5 min on the Escherichia coli chromosomal linkage map. Dabbs ER. J Bacteriol, 1980 Nov. PMID 7000750, Free PMC Article
    4. Overexpression of the LexA-regulated tisAB RNA in E. coli inhibits SOS functions; implications for regulation of the SOS response. Weel-Sneve R, et al. Nucleic Acids Res, 2008 Nov. PMID 18832374, Free PMC Article
    5. Physical mapping of the exuT and uxaC operators by use of exu plasmids and generation of deletion mutants in vitro. Mata-Gilsinger M, et al. J Bacteriol, 1983 Sep. PMID 6309752, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables altronate dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ferrous iron binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in D-galacturonate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within D-galacturonate catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    D-altronate dehydratase
    NP_417562.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3241827..3243314 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417562.1 D-altronate dehydratase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417562.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7XAA4
      Conserved Domains (2) summary
      cd11613
      Location:2 → 81
      SAF_AH_GD; Domains similar to fish antifreeze type III protein
      pfam04295
      Location:106 → 494
      GD_AH_C; D-galactarate dehydratase / Altronate hydrolase, C-terminus
    Nucleotide Protein
    Heading Accession and Version

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