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    waaA KDO transferase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 949048, updated on 3-Dec-2024

    Summary

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    Official Symbol
    waaA
    Official Full Name
    KDO transferase
    Primary source
    ECOCYC:EG10520
    Locus tag
    b3633
    See related
    ASAP:ABE-0011873
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3623; kdtA
    Summary
    WaaA adds 2 Kdo residues to lipid IVA. waaA is an essential gene. [More information is available at EcoGene: EG10520]. The lipopolysaccharide of Escherichia coli K-12 consists of two major components: the hydrophobic lipid A moiety inserted into the outer membrane and the phosphorylated core oligosaccharide . [More information is available at EcoCyc: EG10520].
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    Genomic context

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    Sequence:
    NC_000913.3 (3808540..3809817)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene lipopolysaccharide glucosyltransferase I Neighboring gene lipopolysaccharide core heptosyltransferase 3 Neighboring gene ncRNA Neighboring gene pantetheine-phosphate adenylyltransferase Neighboring gene DNA-formamidopyrimidine glycosylase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crosstalk between the lipopolysaccharide and phospholipid pathways during outer membrane biogenesis in Escherichia coli. Emiola A, et al. Proc Natl Acad Sci U S A, 2016 Mar 15. PMID 26929331, Free PMC Article
    2. Biosynthesis of lipopolysaccharide in Escherichia coli. Cytoplasmic enzymes that attach 3-deoxy-D-manno-octulosonic acid to lipid A. Brozek KA, et al. J Biol Chem, 1989 Apr 25. PMID 2651435
    3. Inhibition of lipopolysaccharide biosynthesis and cell growth following inactivation of the kdtA gene in Escherichia coli. Belunis CJ, et al. J Biol Chem, 1995 Nov 17. PMID 7499229
    4. Dual role of FtsH in regulating lipopolysaccharide biosynthesis in Escherichia coli. Katz C, et al. J Bacteriol, 2008 Nov. PMID 18776015, Free PMC Article
    5. Replacement of lipopolysaccharide with free lipid A molecules in Escherichia coli mutants lacking all core sugars. Reynolds CM, et al. Biochemistry, 2009 Oct 13. PMID 19754149, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables Kdo transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Kdo2-lipid A biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid A biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lipid A biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipopolysaccharide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipopolysaccharide core region biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    KDO transferase
    NP_418090.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3808540..3809817
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418090.1 KDO transferase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418090.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A7D7KC07
      Conserved Domains (1) summary
      PRK05749
      Location:1 → 424
      PRK05749; 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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