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    grxB reduced glutaredoxin 2 [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946926, updated on 17-Dec-2024

    Summary

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    Official Symbol
    grxB
    Official Full Name
    reduced glutaredoxin 2
    Primary source
    ECOCYC:EG12688
    Locus tag
    b1064
    See related
    ASAP:ABE-0003615
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1049
    Summary
    Glutaredoxins are ubiquitous proteins that catalyze the reduction of disulfides via reduced glutathione (GSH). [More information is available at EcoCyc: EG12688].
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    Genomic context

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    Sequence:
    NC_000913.3 (1123407..1124054, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene dihydroorotase Neighboring gene putative lipid-binding lipoprotein YceB Neighboring gene multidrug efflux pump MdtH Neighboring gene ribosomal-protein-S5-alanine N-acetyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Stability and unfolding of reduced Escherichia coli glutaredoxin 2: a monomeric structural homologue of the glutathione transferase family. Gildenhuys S, et al. Biochemistry, 2008 Oct 7. PMID 18788752
    2. Crystallization and preliminary X-ray crystallographic analysis of Escherichia coliglutaredoxin 2 in complex with glutathione and of a cysteine-less variant without glutathione. Sheng J, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2007 Apr 1. PMID 17401194, Free PMC Article
    3. Expression of Escherichia coli glutaredoxin 2 is mainly regulated by ppGpp and sigmaS. Potamitou A, et al. J Biol Chem, 2002 May 17. PMID 11889138
    4. Cloning, overexpression, and characterization of glutaredoxin 2, an atypical glutaredoxin from Escherichia coli. Vlamis-Gardikas A, et al. J Biol Chem, 1997 Apr 25. PMID 9111025
    5. Reactivity of glutaredoxins 1, 2, and 3 from Escherichia coli shows that glutaredoxin 2 is the primary hydrogen donor to ArsC-catalyzed arsenate reduction. Shi J, et al. J Biol Chem, 1999 Dec 17. PMID 10593884

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on complete protein
      Title: Two additional glutaredoxins exist in Escherichia coli: glutaredoxin 3 is a hydrogen donor for ribonucleotide reductase in a thioredoxin/glutaredoxin 1 double mutant.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables glutathione disulfide oxidoreductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    reduced glutaredoxin 2
    NP_415582.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1123407..1124054 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415582.1 reduced glutaredoxin 2 [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415582.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6M9WX06, A0A8S7BIW5, A0A8S7EM69
      Conserved Domains (1) summary
      PRK10387
      Location:1 → 210
      PRK10387; glutaredoxin 2; Provisional
    Nucleotide Protein
    Heading Accession and Version

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