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    setB sugar exporter SetB [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946673, updated on 17-Dec-2024

    Summary

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    Official Symbol
    setB
    Official Full Name
    sugar exporter SetB
    Primary source
    ECOCYC:EG12034
    Locus tag
    b2170
    See related
    ASAP:ABE-0007184
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2163; yeiO
    Summary
    Major Facilitator Superfamily (MFS). [More information is available at EcoGene: EG12034]. SetB is a probable efflux transporter for sugars such as lactose and IPTG. [More information is available at EcoCyc: EG12034].
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    Genomic context

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    Sequence:
    NC_000913.3 (2263863..2265044)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene 1-phosphofructokinase Neighboring gene fructose-specific PTS multiphosphoryl transfer protein FruB Neighboring gene putative metal-chelating domain-containing protein YeiW Neighboring gene elongation factor P-like protein YeiP Neighboring gene putative oxidoreductase YeiQ

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The identification of a new family of sugar efflux pumps in Escherichia coli. Liu JY, et al. Mol Microbiol, 1999 Mar. PMID 10209755
    2. SetB: an integral membrane protein that affects chromosome segregation in Escherichia coli. Espeli O, et al. Mol Microbiol, 2003 Oct. PMID 14617174
    3. Functional and biochemical characterization of Escherichia coli sugar efflux transporters. Liu JY, et al. J Biol Chem, 1999 Aug 13. PMID 10438463
    4. Microbial drug efflux proteins of the major facilitator superfamily. Saidijam M, et al. Curr Drug Targets, 2006 Jul. PMID 16842212
    5. The major facilitator superfamily. Saier MH Jr, et al. J Mol Microbiol Biotechnol, 1999 Nov. PMID 10943556

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables carbohydrate:proton symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carbohydrate:proton symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables carbohydrate:proton symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in D-glucose transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within D-glucose transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within carbohydrate transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within carbohydrate transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in carbohydrate transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to glucose-phosphate stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lactose transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lactose transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sugar exporter SetB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2263863..2265044
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416675.1 sugar exporter SetB [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416675.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376FZB0, A0A8T5ZBQ8
      Conserved Domains (1) summary
      PRK15011
      Location:1 → 393
      PRK15011; sugar efflux transporter SetB
    Nucleotide Protein
    Heading Accession and Version

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