Gstm1 glutathione S-transferase, mu 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gstm1provided by MGI
Official Full Name: glutathione S-transferase, mu 1provided by MGI
Primary source: MGI:MGI:95860
See related: Ensembl:ENSMUSG00000058135 AllianceGenome:MGI:95860
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gstb1; Gstb-1
Summary: Enables identical protein binding activity. Acts upstream of or within cellular response to xenobiotic stimulus. Located in cytosol and mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; liver; and sensory organ. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and lung disease (multiple). Orthologous to human GSTM1 (glutathione S-transferase mu 1) and GSTM5 (glutathione S-transferase mu 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in bladder adult (RPKM 2975.4), liver adult (RPKM 1111.2) and 10 other tissues See more
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Genomic context

Location:: 3 F2.3; 3 46.83 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (107919566..107925289, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (108012250..108017973, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gstm1/Gstt1 is essential for reducing cisplatin ototoxicity in CBA/CaJ mice.
Title: Gstm1/Gstt1 is essential for reducing cisplatin ototoxicity in CBA/CaJ mice.
Glutathione S-transferase mu 1 (GSTM1) and glutathione S-transferase theta 2 (GSTT2) were required in astrocytes for the enhancement of microglia activation during brain inflammation.
Title: Glutathione S-transferases promote proinflammatory astrocyte-microglia communication during brain inflammation.
Six proteins were regulated at both basal and inducible levels exhibiting the largest dynamic range of Nrf2 regulation: cytochrome CYP2A5, GSTM3, GSTM1, ENTPD5,UDPGDH, and EPHX1.
Title: Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: biochemical, pharmacological and toxicological implications.
Genetic variants that cause a decremental change in expression of Gstm1 may permit an environment of exaggerated oxidative stress, leading to susceptibility to vascular remodeling and atherosclerosis
Title: Glutathione S-transferase-micro1 regulates vascular smooth muscle cell proliferation, migration, and oxidative stress.
We overexpressed Hoxa9 and Meis1 in primary hematopoietic cells. Arrays identified c-Myb and a c-Myb target (Gstm1) among the genes with the strongest response to Hoxa9/Meis1.
Title: c-Myb is an essential downstream target for homeobox-mediated transformation of hematopoietic cells.
the gene (GSTM1) encoding the detoxification enzyme glutathione S-transferase M1 is transcriptionally upregulated by Myb
Title: Regulation of the gene encoding glutathione S-transferase M1 (GSTM1) by the Myb oncoprotein.
The Gstm1 gene was represented by two EST clones with similar levels of downregulation.
Title: Smad3-ATF3 signaling mediates TGF-beta suppression of genes encoding Phase II detoxifying proteins.
mitochondrial Gstb1 is induced under oxidative stress
Title: Multiple isoforms of mitochondrial glutathione S-transferases and their differential induction under oxidative stress.
The role of polymorphisms of glutathione S-transferases GSTM1, M3, P1, T1 and A1 in susceptibility to alcoholic liver disease. In addition, oxidant stress is proposed to be an important pathogenic factor in liver damage related to alcohol.
Title: The role of polymorphisms of glutathione S-transferases GSTM1, M3, P1, T1 and A1 in susceptibility to alcoholic liver disease.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6) 1 citation
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Gstm1 (e-PCR), detects polymorphism
- UniSTS:527377

25.MMHAP63FLA4.seq (e-PCR)
- UniSTS:123694

Gstm1 (e-PCR), detects polymorphism
- UniSTS:525988

Gstm1 (e-PCR), detects polymorphism
- UniSTS:526843

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables glutathione binding	ISO Inferred from Sequence Orthology more info
enables glutathione transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione transferase activity	ISO Inferred from Sequence Orthology more info
enables glutathione transferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables nickel cation binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables steroid binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to xenobiotic stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in glutathione derivative biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in glutathione metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glutathione metabolic process	ISO Inferred from Sequence Orthology more info
involved_in hepoxilin biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in prostaglandin metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in xenobiotic catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in intercellular bridge	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in myelin sheath	HDA more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: glutathione S-transferase Mu 1

Names: GST 1-1; GST class-mu 1; glutathione S-transferase GT8.7; pmGT10

NP_001361607.1

EC 2.5.1.18

NP_034488.1

EC 2.5.1.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001374678.1 → NP_001361607.1 glutathione S-transferase Mu 1 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AC079042, AL671877

Consensus CDS

CCDS89677.1

UniProtKB/TrEMBL

A2AE89

Related

ENSMUSP00000118874.3, ENSMUST00000126593.3

Conserved Domains (2) summary

cd03209
Location:92 → 238

GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases

cd03075
Location:3 → 84

GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
NM_010358.5 → NP_034488.1 glutathione S-transferase Mu 1 isoform 2

See identical proteins and their annotated locations for NP_034488.1

Status: VALIDATED

Source sequence(s)

AI841190, AL671877, BC046758

Consensus CDS

CCDS17747.1

UniProtKB/Swiss-Prot

A2AE90, P10649, Q58ET5

Related

ENSMUSP00000004140.5, ENSMUST00000004140.11

Conserved Domains (2) summary

cd03209
Location:92 → 212

GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases

cd03075
Location:3 → 84

GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...