Dolk dolichol kinase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dolkprovided by MGI
Official Full Name: dolichol kinaseprovided by MGI
Primary source: MGI:MGI:2677836
See related: Ensembl:ENSMUSG00000075419 AllianceGenome:MGI:2677836
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tmem15; mKIAA1094
Summary: Predicted to enable dolichol kinase activity. Predicted to be involved in dolichyl monophosphate biosynthetic process and protein mannosylation. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Im. Orthologous to human DOLK (dolichol kinase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human all
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Genomic context

Location:: 2 B; 2 21.49 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (30174241..30176366, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (30284229..30286354, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables dolichol kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables dolichol kinase activity	ISO Inferred from Sequence Orthology more info
enables dolichol kinase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in dolichol phosphate mannose biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in dolichyl monophosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in dolichyl monophosphate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in dolichyl monophosphate biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein N-linked glycosylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein mannosylation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: dolichol kinase

Names: transmembrane protein 15

NP_808316.1

EC 2.7.1.108

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.