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    Klrc1 killer cell lectin-like receptor subfamily C, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 16641, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Klrc1provided by MGI
    Official Full Name
    killer cell lectin-like receptor subfamily C, member 1provided by MGI
    Primary source
    MGI:MGI:1336161
    See related
    Ensembl:ENSMUSG00000030167 AllianceGenome:MGI:1336161
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NKG2A; NKG2B; CD159a
    Summary
    Predicted to enable HLA-E specific inhibitory MHC class Ib receptor activity and MHC class I protein complex binding activity. Predicted to be involved in positive regulation of natural killer cell mediated cytotoxicity and stimulatory C-type lectin receptor signaling pathway. Located in external side of plasma membrane. Is expressed in liver. Orthologous to several human genes including KLRC1 (killer cell lectin like receptor C1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Klrc1 in Genome Data Viewer
    Location:
    6 F3; 6 63.44 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (129642978..129659815, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (129666015..129682852, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene killer cell lectin-like receptor subfamily C, member 3 Neighboring gene killer cell lectin-like receptor subfamily C, member 2 Neighboring gene microRNA 680-1 Neighboring gene PQ loop repeat containing pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Natural killer cells protect mice from DSS-induced colitis by regulating neutrophil function via the NKG2A receptor. Hall LJ, et al. Mucosal Immunol, 2013 Sep. PMID 23340823
    2. Tissue-protective effects of NKG2A in immune-mediated clearance of virus infection. Ely KH, et al. PLoS One, 2014. PMID 25251060, Free PMC Article
    3. The human CD94 gene encodes multiple, expressible transcripts including a new partner of NKG2A/B. Lieto LD, et al. Genes Immun, 2006 Jan. PMID 16237464
    4. Molecular cloning of mouse NKG2A and C. Silver ET, et al. Immunogenetics, 1999 Jul. PMID 10369936
    5. HLA reduces killer cell Ig-like receptor expression level and frequency in a humanized mouse model. van Bergen J, et al. J Immunol, 2013 Mar 15. PMID 23390293, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. KLRC1 knockout overcomes HLA-E-mediated inhibition and improves NK cell antitumor activity against solid tumors.
      Title: KLRC1 knockout overcomes HLA-E-mediated inhibition and improves NK cell antitumor activity against solid tumors.
    2. Combination of NKG2A and PD-1 Blockade Improves Radiotherapy Response in Radioresistant Tumors.
      Title: Combination of NKG2A and PD-1 Blockade Improves Radiotherapy Response in Radioresistant Tumors.
    3. NKG2A downregulation evades the HLA-E cancer immune-checkpoint, and increases the anti-tumor activity of NK cell infusions
      Title: Blocking expression of inhibitory receptor NKG2A overcomes tumor resistance to NK cells.
    4. Data suggest that NKG2A Receptor (NKG2A) and the inhibitory members of NK cell lectin-like receptor subfamily A (Ly49) family receptors synergize to regulate NK cell education.
      Title: Synergized regulation of NK cell education by NKG2A and specific Ly49 family members.
    5. Data suggest that the Cd94(LocA)/NKG2A receptor (NKG2A) heterodimeric receptor is widely expressed among M. musculus subspecies musculus.
      Title: Evidence of functional Cd94 polymorphism in a free-living house mouse population.
    6. Liver cNK cells' hyporesponsiveness to stimulation through activating receptors is independent of IL-10, but correlates with decreased NKG2A expression compared to trNK cells.
      Title: Expression of the inhibitory receptor NKG2A correlates with increased liver and splenic NK cell response to activating receptor engagement.
    7. Here, we provide a new anti-inflammation mechanism about ANXA1 secreted from injured IECs, where ANXA1 can stimulate the expression of NKG2A in NK cells that affect the recruitment and activity of neutrophils necessary for pathology of colitis.
      Title: The ANXA1 released from intestinal epithelial cells alleviate DSS-induced colitis by improving NKG2A expression of Natural Killer cells.
    8. NKG2A optimizes CD8(+) T cell responses during an acute poxvirus infection.
      Title: The Inhibitory Receptor NKG2A Sustains Virus-Specific CD8⁺ T Cells in Response to a Lethal Poxvirus Infection.
    9. Results demonstrate the immunoregulatory role of CD8(+) NKG2A expression in virus infection, which negatively regulates T cell effector functions and contributes to protection of tissue integrity during virus clearance.
      Title: Tissue-protective effects of NKG2A in immune-mediated clearance of virus infection.
    10. role in NK cell-mediated protection from DSS-induced colitis
      Title: Natural killer cells protect mice from DSS-induced colitis by regulating neutrophil function via the NKG2A receptor.
    Submit: New GeneRIF Correction See all GeneRIFs (23)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables HLA-E specific inhibitory MHC class Ib receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables MHC class I protein complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables inhibitory MHC class Ib receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of natural killer cell mediated cytotoxicity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in stimulatory C-type lectin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    NKG2-A/NKG2-B type II integral membrane protein
    Names
    Cluster of Differentiation 159a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136068.2 → NP_001129540.1  NKG2-A/NKG2-B type II integral membrane protein isoform 1

      See identical proteins and their annotated locations for NP_001129540.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC171002, AF106008
      Consensus CDS
      CCDS51926.1
      UniProtKB/TrEMBL
      A6H5Z4, Q9Z202
      Related
      ENSMUSP00000032270.7, ENSMUST00000032270.13
      Conserved Domains (1) summary
      cd03593
      Location:128 → 240
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

    2. NM_001288664.1 → NP_001275593.1  NKG2-A/NKG2-B type II integral membrane protein isoform 3

      See identical proteins and their annotated locations for NP_001275593.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. It encodes isoform 3 which is shorter than isoform 1.
      Source sequence(s)
      AC171002, AF106008, AF106009
      Consensus CDS
      CCDS80621.1
      UniProtKB/TrEMBL
      E9QAJ6, Q9WVJ8
      Related
      ENSMUSP00000130762.2, ENSMUST00000169545.8
      Conserved Domains (1) summary
      cd03593
      Location:94 → 206
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

    3. NM_010652.2 → NP_034782.1  NKG2-A/NKG2-B type II integral membrane protein isoform 2

      See identical proteins and their annotated locations for NP_034782.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.
      Source sequence(s)
      AC171002, AF106008, AF109784
      Consensus CDS
      CCDS39663.1
      UniProtKB/TrEMBL
      A6H5Z4, Q9WU32
      Related
      ENSMUSP00000114017.2, ENSMUST00000118447.2
      Conserved Domains (1) summary
      cd03593
      Location:111 → 223
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      129642978..129659815 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321418.1 → XP_017176907.1  NKG2-A/NKG2-B type II integral membrane protein isoform X3

      UniProtKB/TrEMBL
      E9QAJ6, Q9WVJ8
      Conserved Domains (1) summary
      cd03593
      Location:94 → 206
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

    2. XM_011241237.1 → XP_011239539.1  NKG2-A/NKG2-B type II integral membrane protein isoform X2

      See identical proteins and their annotated locations for XP_011239539.1

      UniProtKB/TrEMBL
      A6H5Z4, Q9WU32
      Conserved Domains (1) summary
      cd03593
      Location:111 → 223
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

    3. XM_011241236.1 → XP_011239538.1  NKG2-A/NKG2-B type II integral membrane protein isoform X1

      See identical proteins and their annotated locations for XP_011239538.1

      UniProtKB/TrEMBL
      A6H5Z4, Q9Z202
      Conserved Domains (1) summary
      cd03593
      Location:128 → 240
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
    Nucleotide Protein Strain
    Heading Accession and Version

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