Nup35 nucleoporin 35 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nup35provided by MGI
Official Full Name: nucleoporin 35provided by MGI
Primary source: MGI:MGI:1916732
See related: Ensembl:ENSMUSG00000026999 AllianceGenome:MGI:1916732
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MP44; NO44; 35kDa; 2310006I24Rik; 5330402E05Rik
Summary: Enables identical protein binding activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in nucleus and plasma membrane. Predicted to be part of nuclear pore central transport channel and nuclear pore nuclear basket. Is expressed in cerebellum. Used to study intestinal pseudo-obstruction. Orthologous to human NUP35 (nucleoporin 35). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in testis adult (RPKM 15.4), whole brain E14.5 (RPKM 7.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 C3; 2 48.31 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (80469156..80490415)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (80638812..80660071)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The results suggest that Nup35 is putatively phosphorylated and released to the cytoplasm after resumption of meiosis, and it regulates spindle assembly and chromosome alignment.
Title: Nucleoporin35 is a novel microtubule associated protein functioning in oocyte meiotic spindle architecture.
Our study also raises the possibility that Nup35 polymorphisms could contribute to some cases of Chronic intestinal pseudo-obstruction
Title: A Novel Mutation in Nucleoporin 35 Causes Murine Degenerative Colonic Smooth Muscle Myopathy.
The crystal structure of the Nup35 RNA-recognition motif (RRM) domain has been solved; the Nup35 RRM domain monomer adopts the characteristic betaalphabetabetaalphabeta topology revealing a new homodimerization mode.
Title: The crystal structure of mouse Nup35 reveals atypical RNP motifs and novel homodimerization of the RRM domain.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (1)
Targeted (2)
Transgenic (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D9Mit34.1 (e-PCR), detects polymorphism
- UniSTS:131903

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of nuclear pore	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of nuclear pore	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in NLS-bearing protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in nuclear pore organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleocytoplasmic transport	NAS Non-traceable Author Statement more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in nuclear lamina	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
part_of nuclear pore	NAS Non-traceable Author Statement more info	PubMed
part_of nuclear pore central transport channel	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear pore nuclear basket	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: nucleoporin NUP35

Names: 35 kDa nucleoporin; mitotic phosphoprotein 44; nuclear pore complex protein Nup53

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001190179.1 → NP_001177108.1 nucleoporin NUP35 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR/coding region and uses a downstream start codon, compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AK136109, AK145775, CA560987, DV653588

UniProtKB/Swiss-Prot

Q8R4R6

Conserved Domains (1) summary

cd12722
Location:154 → 227

RRM_Nup53; RNA recognition motif in nucleoporin Nup53
NM_027091.4 → NP_081367.1 nucleoporin NUP35 isoform 1

See identical proteins and their annotated locations for NP_081367.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).

Source sequence(s)

AK136109, AK145775, BY272877

Consensus CDS

CCDS16179.1

UniProtKB/Swiss-Prot

A2ATJ3, Q8R4R6, Q9D7J2

Related

ENSMUSP00000028382.7, ENSMUST00000028382.13

Conserved Domains (1) summary

cd12722
Location:171 → 244

RRM_Nup53; RNA recognition motif in nucleoporin Nup53