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    Dip2a disco interacting protein 2 homolog A [ Mus musculus (house mouse) ]

    Gene ID: 64451, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dip2aprovided by MGI
    Official Full Name
    disco interacting protein 2 homolog Aprovided by MGI
    Primary source
    MGI:MGI:2385920
    See related
    Ensembl:ENSMUSG00000020231 AllianceGenome:MGI:2385920
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dip2; mKIAA0184; Kiaa0184-hp; 4931420H10Rik
    Summary
    Enables acetate-CoA ligase activity. Involved in several processes, including dendritic spine morphogenesis; positive regulation of peptidyl-lysine acetylation; and regulation of modification of postsynaptic actin cytoskeleton. Located in dendritic spine and mitochondrion. Is active in glutamatergic synapse and postsynapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and skeleton. Orthologous to human DIP2A (disco interacting protein 2 homolog A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 15.1), colon adult (RPKM 14.6) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dip2a in Genome Data Viewer
    Location:
    10 C1; 10 38.76 cM
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (76098581..76181194, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (76263034..76345360, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_27175 Neighboring gene microRNA 678 Neighboring gene protein arginine N-methyltransferase 2 Neighboring gene S100 protein, beta polypeptide, neural Neighboring gene predicted gene, 40699 Neighboring gene STARR-seq mESC enhancer starr_27177 Neighboring gene pericentrin (kendrin) Neighboring gene RIKEN cDNA 1700094J05 gene Neighboring gene STARR-seq mESC enhancer starr_27178 Neighboring gene STARR-seq mESC enhancer starr_27179 Neighboring gene predicted gene 9744

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dysregulation of AMPK-mTOR signaling leads to comorbid anxiety in Dip2a KO mice. Ma J, et al. Cereb Cortex, 2023 Apr 4. PMID 36227200
    2. A pilot study to investigate the alteration of gut microbial profile in Dip2a knockout mice. Zhang Y, et al. Int Microbiol, 2022 May. PMID 34562157
    3. DIP2A is involved in SOD-mediated antioxidative reactions in murine brain. Bai LL, et al. Free Radic Biol Med, 2021 May 20. PMID 33781892
    4. Peri-natal growth retardation rate and fat mass accumulation in mice lacking Dip2A is dependent on the dietary composition. Kinatukara P, et al. Transgenic Res, 2020 Dec. PMID 33184751
    5. Large genomic fragment deletions and insertions in mouse using CRISPR/Cas9. Zhang L, et al. PLoS One, 2015. PMID 25803037, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dysregulation of AMPK-mTOR signaling leads to comorbid anxiety in Dip2a KO mice.
      Title: Dysregulation of AMPK-mTOR signaling leads to comorbid anxiety in Dip2a KO mice.
    2. A pilot study to investigate the alteration of gut microbial profile in Dip2a knockout mice.
      Title: A pilot study to investigate the alteration of gut microbial profile in Dip2a knockout mice.
    3. Peri-natal growth retardation rate and fat mass accumulation in mice lacking Dip2A is dependent on the dietary composition.
      Title: Peri-natal growth retardation rate and fat mass accumulation in mice lacking Dip2A is dependent on the dietary composition.
    4. DIP2A is involved in SOD-mediated antioxidative reactions in murine brain.
      Title: DIP2A is involved in SOD-mediated antioxidative reactions in murine brain.
    5. Autism candidate gene DIP2A regulates spine morphogenesis via acetylation of cortactin.
      Title: Autism candidate gene DIP2A regulates spine morphogenesis via acetylation of cortactin.
    6. Genome wide transcriptional analysis using wild type and Dip2a knockout mice in brain and lung at embryonic day 19.5 (E19.5) provided a genetic basis of molecular function of these genes.
      Title: Transcriptome profiling of mouse brain and lung under Dip2a regulation using RNA-sequencing.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4)  1 citation
    • Targeted (4) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acetate-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in acetyl-CoA biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in dendritic spine morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of peptidyl-lysine acetylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of modification of postsynaptic actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of modification of postsynaptic actin cytoskeleton IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in regulation of modification of postsynaptic actin cytoskeleton IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in dendritic spine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynapse IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    disco-interacting protein 2 homolog A
    Names
    DIP2 disco-interacting protein 2 homolog A
    DIP2 homolog A
    NP_001074888.2
    XP_006514002.1
    XP_006514003.1
    XP_006514004.1
    XP_030101068.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081419.2 → NP_001074888.2  disco-interacting protein 2 homolog A

      Status: VALIDATED

      Source sequence(s)
      AB093213, AI845124, AK050040, AK052899
      Consensus CDS
      CCDS35944.2
      UniProtKB/TrEMBL
      D3Z7D3, F8WI56
      Related
      ENSMUSP00000043710.8, ENSMUST00000036033.14
      Conserved Domains (4) summary
      COG0318
      Location:321 → 914
      CaiC; Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]
      pfam00501
      Location:982 → 1456
      AMP-binding; AMP-binding enzyme
      pfam06464
      Location:9 → 122
      DMAP_binding; DMAP1-binding Domain
      cl17068
      Location:347 → 911
      AFD_class_I; Adenylate forming domain, Class I superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      76098581..76181194 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513941.5 → XP_006514004.1  disco-interacting protein 2 homolog A isoform X3

      UniProtKB/TrEMBL
      D3Z7D3
      Conserved Domains (2) summary
      cd05905
      Location:918 → 1492
      Dip2; Disco-interacting protein 2 (Dip2)
      pfam06464
      Location:10 → 122
      DMAP_binding; DMAP1-binding Domain

    2. XM_006513939.5 → XP_006514002.1  disco-interacting protein 2 homolog A isoform X1

      UniProtKB/TrEMBL
      D3Z7D3
      Conserved Domains (2) summary
      cd05905
      Location:994 → 1568
      Dip2; Disco-interacting protein 2 (Dip2)
      pfam06464
      Location:10 → 122
      DMAP_binding; DMAP1-binding Domain

    3. XM_006513940.5 → XP_006514003.1  disco-interacting protein 2 homolog A isoform X2

      UniProtKB/Swiss-Prot
      E0CXM7, Q8BWT5, Q8CHI0
      Related
      ENSMUSP00000125184.2, ENSMUST00000160048.8
      Conserved Domains (2) summary
      cd05905
      Location:955 → 1529
      Dip2; Disco-interacting protein 2 (Dip2)
      pfam06464
      Location:10 → 83
      DMAP_binding; DMAP1-binding Domain

    4. XM_030245208.2 → XP_030101068.1  disco-interacting protein 2 homolog A isoform X4

      Conserved Domains (2) summary
      pfam06464
      Location:10 → 122
      DMAP_binding; DMAP1-binding Domain
      cl17068
      Location:266 → 756
      AFD_class_I; Adenylate forming domain, Class I superfamily

    RNA

    1. XR_001779571.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BWT5.3 GenPept UniProtKB/Swiss-Prot:Q8BWT5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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