Tpd52 tumor protein D52 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tpd52provided by MGI
Official Full Name: tumor protein D52provided by MGI
Primary source: MGI:MGI:107749
See related: Ensembl:ENSMUSG00000027506 AllianceGenome:MGI:107749
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mD52
Summary: Enables protein homodimerization activity. Acts upstream of or within positive regulation of cell population proliferation. Is active in glutamatergic synapse. Is expressed in several structures, including central nervous system; genitourinary system; gut; respiratory system; and sensory organ. Orthologous to human TPD52 (tumor protein D52). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in large intestine adult (RPKM 34.0), colon adult (RPKM 25.8) and 26 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 3 A1; 3 2.23 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (8991590..9069824, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (8926530..9005393, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the important roles of TPD52 and TPD54, which work oppositely, in the terminal differentiation of chondrocytes during endochondral ossification.
Title: Tumor Proteins D52 and D54 Have Opposite Effects on the Terminal Differentiation of Chondrocytes.
findings uncover a new isoform-specific role for TPD52 in promoting intracellular lipid storage, which might be relevant to TPD52 overexpression in cancer.
Title: TPD52 expression increases neutral lipid storage within cultured cells.
Together, these data suggest that mD52 expression in 3T3 cells initiated cellular transformation, tumorigenesis, and progression to metastasis.
Title: Induction of tumorigenesis and metastasis by the murine orthologue of tumor protein D52.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

NoName (e-PCR)
- UniSTS:224367

AI043038 (e-PCR)
- UniSTS:178804

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in B cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in B cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IEP Inferred from Expression Pattern more info	PubMed
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in synapse	EXP Inferred from Experiment more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	IEP Inferred from Expression Pattern more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: tumor protein D52

NP_001020432.1

EC 2.7.1.21

NP_001020433.1

EC 2.7.1.21

NP_001020434.1

EC 2.7.1.21

NP_001020435.1

EC 2.7.1.21

NP_001344001.1

EC 2.7.1.21

NP_001344002.1

EC 2.7.1.21

NP_001344003.1

EC 2.7.1.21

NP_033438.1

EC 2.7.1.21

XP_006530128.1

EC 2.7.1.21

XP_006530129.1

EC 2.7.1.21

XP_006530130.1

EC 2.7.1.21

XP_006530131.1

EC 2.7.1.21

XP_006530134.1

EC 2.7.1.21

XP_011246444.1

EC 2.7.1.21

XP_011246445.1

EC 2.7.1.21

XP_011246446.1

EC 2.7.1.21

XP_011246447.1

EC 2.7.1.21

XP_030108413.1

EC 2.7.1.21

XP_036018910.1

EC 2.7.1.21

XP_036018911.1

EC 2.7.1.21

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025261.3 → NP_001020432.1 tumor protein D52 isoform 1

Status: VALIDATED

Source sequence(s)

AC133935, AC161056

Consensus CDS

CCDS38387.1

UniProtKB/TrEMBL

F8WHQ1

Related

ENSMUSP00000091943.5, ENSMUST00000094381.11

Conserved Domains (1) summary

pfam04201
Location:51 → 232

TPD52; Tumour protein D52 family
NM_001025262.3 → NP_001020433.1 tumor protein D52 isoform 2

See identical proteins and their annotated locations for NP_001020433.1

Status: VALIDATED

Source sequence(s)

AC133935, AC161056

Consensus CDS

CCDS38386.1

UniProtKB/Swiss-Prot

Q545M5, Q62393, Q8CCU1, Q8K564, Q99KP8

Related

ENSMUSP00000088913.6, ENSMUST00000091354.12

Conserved Domains (1) summary

pfam04201
Location:51 → 209

TPD52; Tumour protein D52 family
NM_001025263.3 → NP_001020434.1 tumor protein D52 isoform 3

See identical proteins and their annotated locations for NP_001020434.1

Status: VALIDATED

Source sequence(s)

AC133935, AC161056

Consensus CDS

CCDS38384.1

UniProtKB/TrEMBL

D3Z125

Related

ENSMUSP00000088914.6, ENSMUST00000091355.12

Conserved Domains (1) summary

pfam04201
Location:12 → 184

TPD52; Tumour protein D52 family
NM_001025264.3 → NP_001020435.1 tumor protein D52 isoform 4

Status: VALIDATED

Source sequence(s)

AC133935, AC161056

Consensus CDS

CCDS38385.1

UniProtKB/TrEMBL

D3Z125, E9PUA7

Related

ENSMUSP00000066826.8, ENSMUST00000063496.14

Conserved Domains (1) summary

pfam04201
Location:12 → 179

TPD52; Tumour protein D52 family
NM_001357072.1 → NP_001344001.1 tumor protein D52 isoform 6

Status: VALIDATED

Source sequence(s)

AC133935, AC161056

Conserved Domains (1) summary

pfam04201
Location:152 → 301

TPD52; tumor protein D52 family
NM_001357073.1 → NP_001344002.1 tumor protein D52 isoform 7

Status: VALIDATED

Source sequence(s)

AC133935, AC161056

Conserved Domains (1) summary

pfam04201
Location:108 → 289

TPD52; tumor protein D52 family
NM_001357074.2 → NP_001344003.1 tumor protein D52 isoform 8

Status: VALIDATED

Source sequence(s)

AC133935, AC161056

UniProtKB/TrEMBL

D3Z125

Conserved Domains (1) summary

pfam04201
Location:12 → 193

TPD52; tumor protein D52 family
NM_001428700.1 → NP_001415629.1 tumor protein D52 isoform 9

Status: VALIDATED

Source sequence(s)

AC133935, AC161056
NM_001428701.1 → NP_001415630.1 tumor protein D52 isoform 10

Status: VALIDATED

Source sequence(s)

AC133935, AC161056

UniProtKB/TrEMBL

D3Z7X7
NM_001428702.1 → NP_001415631.1 tumor protein D52 isoform 11

Status: VALIDATED

Source sequence(s)

AC133935, AC161056
NM_001428703.1 → NP_001415632.1 tumor protein D52 isoform 12

Status: VALIDATED

Source sequence(s)

AC133935, AC161056
NM_001428705.1 → NP_001415634.1 tumor protein D52 isoform 13

Status: VALIDATED

Source sequence(s)

AC133935, AC161056
NM_009412.4 → NP_033438.1 tumor protein D52 isoform 5

See identical proteins and their annotated locations for NP_033438.1

Status: VALIDATED

Source sequence(s)

AC133935, AC161056

Consensus CDS

CCDS50860.1

UniProtKB/TrEMBL

D3Z125

Related

ENSMUSP00000112830.2, ENSMUST00000120143.8

Conserved Domains (1) summary

pfam04201
Location:12 → 170

TPD52; Tumour protein D52 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

8991590..9069824 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030252553.2 → XP_030108413.1 tumor protein D52 isoform X9

Related

ENSMUSP00000119899.2, ENSMUST00000134788.8

Conserved Domains (1) summary

pfam04201
Location:49 → 207

TPD52; tumor protein D52 family
XM_011248144.2 → XP_011246446.1 tumor protein D52 isoform X3

UniProtKB/TrEMBL

D3Z7X7

Conserved Domains (1) summary

pfam04201
Location:60 → 218

TPD52; tumor protein D52 family
XM_011248142.2 → XP_011246444.1 tumor protein D52 isoform X1

UniProtKB/TrEMBL

D3Z7X7

Conserved Domains (1) summary

pfam04201
Location:60 → 232

TPD52; tumor protein D52 family
XM_011248143.2 → XP_011246445.1 tumor protein D52 isoform X2

UniProtKB/TrEMBL

D3Z7X7

Conserved Domains (1) summary

pfam04201
Location:60 → 227

TPD52; tumor protein D52 family
XM_006530067.5 → XP_006530130.1 tumor protein D52 isoform X7

Conserved Domains (1) summary

pfam04201
Location:51 → 223

TPD52; tumor protein D52 family
XM_006530068.5 → XP_006530131.1 tumor protein D52 isoform X8

Conserved Domains (1) summary

pfam04201
Location:51 → 218

TPD52; tumor protein D52 family
XM_036163017.1 → XP_036018910.1 tumor protein D52 isoform X11

UniProtKB/TrEMBL

D3Z637

Related

ENSMUSP00000113368.2, ENSMUST00000121038.8

Conserved Domains (1) summary

pfam04201
Location:21 → 161

TPD52; tumor protein D52 family
XM_006530066.5 → XP_006530129.1 tumor protein D52 isoform X5

Conserved Domains (1) summary

pfam04201
Location:49 → 230

TPD52; tumor protein D52 family
XM_036163018.1 → XP_036018911.1 tumor protein D52 isoform X12

Conserved Domains (1) summary

pfam04201
Location:12 → 128

TPD52; tumor protein D52 family
XM_011248145.3 → XP_011246447.1 tumor protein D52 isoform X6

UniProtKB/TrEMBL

D3Z7X7

Conserved Domains (1) summary

pfam04201
Location:60 → 176

TPD52; tumor protein D52 family
XM_006530065.5 → XP_006530128.1 tumor protein D52 isoform X4

Conserved Domains (1) summary

pfam04201
Location:56 → 237

TPD52; tumor protein D52 family
XM_006530071.3 → XP_006530134.1 tumor protein D52 isoform X10

UniProtKB/TrEMBL

D3Z637

Conserved Domains (1) summary

pfam04201
Location:21 → 170

TPD52; tumor protein D52 family