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    Mthfsd methenyltetrahydrofolate synthetase domain containing [ Mus musculus (house mouse) ]

    Gene ID: 234814, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mthfsdprovided by MGI
    Official Full Name
    methenyltetrahydrofolate synthetase domain containingprovided by MGI
    Primary source
    MGI:MGI:2679252
    See related
    Ensembl:ENSMUSG00000031816 AllianceGenome:MGI:2679252
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C920004D05
    Summary
    Predicted to enable RNA binding activity. Predicted to be active in cytoplasm. Orthologous to human MTHFSD (methenyltetrahydrofolate synthetase domain containing). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 13.1), limb E14.5 (RPKM 12.4) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Mthfsd in Genome Data Viewer
    Location:
    8 E1; 8 70.31 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (121818367..121835152, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (121091628..121108413, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene Foxf1 adjacent non-coding developmental regulatory RNA Neighboring gene forkhead box F1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:123632389-123632572 Neighboring gene STARR-positive B cell enhancer ABC_E9747 Neighboring gene forkhead box C2 Neighboring gene forkhead box L1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC62465

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding  
    Component Evidence Code Pubs
    is_active_in cytoplasm  

    General protein information

    Preferred Names
    methenyltetrahydrofolate synthase domain-containing protein
    Names
    methenyltetrahydrofolate synthetase domain-containing protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166482.2NP_001159954.1  methenyltetrahydrofolate synthase domain-containing protein isoform 1

      See identical proteins and their annotated locations for NP_001159954.1

      Status: VALIDATED

      Source sequence(s)
      AC127554
      Consensus CDS
      CCDS52691.1
      UniProtKB/Swiss-Prot
      Q3URQ7, Q80WS4, Q8BUM0
      Related
      ENSMUSP00000112116.3, ENSMUST00000116415.9
      Conserved Domains (2) summary
      cl00360
      Location:9210
      5-FTHF_cyc-lig; 5-formyltetrahydrofolate cyclo-ligase family
      cl17169
      Location:297366
      RRM_SF; RNA recognition motif (RRM) superfamily
    2. NM_001372381.1NP_001359310.1  methenyltetrahydrofolate synthase domain-containing protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC127554
      Conserved Domains (2) summary
      cl00360
      Location:9206
      5-FTHF_cyc-lig; 5-formyltetrahydrofolate cyclo-ligase family
      cl17169
      Location:297366
      RRM_SF; RNA recognition motif (RRM) superfamily
    3. NM_001372383.1NP_001359312.1  methenyltetrahydrofolate synthase domain-containing protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC127554
      Conserved Domains (2) summary
      cl00360
      Location:9206
      5-FTHF_cyc-lig; 5-formyltetrahydrofolate cyclo-ligase family
      cl17169
      Location:297366
      RRM_SF; RNA recognition motif (RRM) superfamily
    4. NM_001372384.1NP_001359313.1  methenyltetrahydrofolate synthase domain-containing protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC127554
      UniProtKB/Swiss-Prot
      Q3URQ7, Q80WS4, Q8BUM0
      Conserved Domains (2) summary
      cl00360
      Location:9210
      5-FTHF_cyc-lig; 5-formyltetrahydrofolate cyclo-ligase family
      cl17169
      Location:297366
      RRM_SF; RNA recognition motif (RRM) superfamily
    5. NM_001372385.1NP_001359314.1  methenyltetrahydrofolate synthase domain-containing protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC127554
      Conserved Domains (2) summary
      cl00360
      Location:10187
      5-FTHF_cyc-lig; 5-formyltetrahydrofolate cyclo-ligase family
      cl17169
      Location:278347
      RRM_SF; RNA recognition motif (RRM) superfamily
    6. NM_001372386.1NP_001359315.1  methenyltetrahydrofolate synthase domain-containing protein isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC127554
      Conserved Domains (1) summary
      cl00360
      Location:9210
      5-FTHF_cyc-lig; 5-formyltetrahydrofolate cyclo-ligase family
    7. NM_001372387.1NP_001359316.1  methenyltetrahydrofolate synthase domain-containing protein isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC127554
      UniProtKB/TrEMBL
      D3Z4L1
      Related
      ENSMUSP00000117429.2, ENSMUST00000133037.8
      Conserved Domains (1) summary
      cl00360
      Location:9206
      5-FTHF_cyc-lig; 5-formyltetrahydrofolate cyclo-ligase family
    8. NM_001372388.1NP_001359317.1  methenyltetrahydrofolate synthase domain-containing protein isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC127554
      UniProtKB/TrEMBL
      D3Z0Q4
      Conserved Domains (1) summary
      cl00360
      Location:10187
      5-FTHF_cyc-lig; 5-formyltetrahydrofolate cyclo-ligase family
    9. NM_001372389.1NP_001359318.1  methenyltetrahydrofolate synthase domain-containing protein isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC124170, AC127554
      Conserved Domains (1) summary
      cl00360
      Location:9206
      5-FTHF_cyc-lig; 5-formyltetrahydrofolate cyclo-ligase family
    10. NM_172761.4NP_766349.1  methenyltetrahydrofolate synthase domain-containing protein isoform 2

      See identical proteins and their annotated locations for NP_766349.1

      Status: VALIDATED

      Source sequence(s)
      AC127554
      Consensus CDS
      CCDS22723.1
      UniProtKB/Swiss-Prot
      Q3URQ7
      Related
      ENSMUSP00000044172.6, ENSMUST00000047282.12
      Conserved Domains (2) summary
      cl00360
      Location:10187
      5-FTHF_cyc-lig; 5-formyltetrahydrofolate cyclo-ligase family
      cl17169
      Location:278347
      RRM_SF; RNA recognition motif (RRM) superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      121818367..121835152 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530939.4XP_006531002.1  methenyltetrahydrofolate synthase domain-containing protein isoform X3

      See identical proteins and their annotated locations for XP_006531002.1

      Conserved Domains (2) summary
      cl00360
      Location:10187
      5-FTHF_cyc-lig; 5-formyltetrahydrofolate cyclo-ligase family
      cl17169
      Location:278347
      RRM_SF; RNA recognition motif (RRM) superfamily
    2. XM_006530935.5XP_006530998.1  methenyltetrahydrofolate synthase domain-containing protein isoform X1

      Conserved Domains (2) summary
      cl00360
      Location:81278
      5-FTHF_cyc-lig; 5-formyltetrahydrofolate cyclo-ligase family
      cl17169
      Location:369438
      RRM_SF; RNA recognition motif (RRM) superfamily
    3. XM_036153974.1XP_036009867.1  methenyltetrahydrofolate synthase domain-containing protein isoform X3

      Conserved Domains (2) summary
      cl00360
      Location:10187
      5-FTHF_cyc-lig; 5-formyltetrahydrofolate cyclo-ligase family
      cl17169
      Location:278347
      RRM_SF; RNA recognition motif (RRM) superfamily
    4. XM_036153975.1XP_036009868.1  methenyltetrahydrofolate synthase domain-containing protein isoform X4

      UniProtKB/TrEMBL
      D3Z0Q4
      Related
      ENSMUSP00000115382.2, ENSMUST00000139782.8
      Conserved Domains (1) summary
      cl00360
      Location:10187
      5-FTHF_cyc-lig; 5-formyltetrahydrofolate cyclo-ligase family
    5. XM_006530937.4XP_006531000.1  methenyltetrahydrofolate synthase domain-containing protein isoform X2

      Conserved Domains (1) summary
      cl00360
      Location:81278
      5-FTHF_cyc-lig; 5-formyltetrahydrofolate cyclo-ligase family
    6. XM_017312753.3XP_017168242.1  methenyltetrahydrofolate synthase domain-containing protein isoform X6

      Conserved Domains (1) summary
      cl00360
      Location:81193
      5-FTHF_cyc-lig; 5-formyltetrahydrofolate cyclo-ligase family
    7. XM_036153976.1XP_036009869.1  methenyltetrahydrofolate synthase domain-containing protein isoform X7

    8. XM_017312752.2XP_017168241.1  methenyltetrahydrofolate synthase domain-containing protein isoform X5

      Conserved Domains (1) summary
      cl00360
      Location:81167
      5-FTHF_cyc-lig; 5-formyltetrahydrofolate cyclo-ligase family
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