Etnk1 ethanolamine kinase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Etnk1provided by MGI
Official Full Name: ethanolamine kinase 1provided by MGI
Primary source: MGI:MGI:1922570
See related: Ensembl:ENSMUSG00000030275 AllianceGenome:MGI:1922570
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: EKI1; D6Ertd3e; 1110061E11Rik; 4930555L11Rik
Summary: Predicted to enable ethanolamine kinase activity. Predicted to be involved in phosphatidylethanolamine biosynthetic process. Predicted to be active in cytoplasm. Is expressed in several structures, including early embryo; endocrine gland; ganglia; male reproductive gland or organ; and retina. Orthologous to human ETNK1 (ethanolamine kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in frontal lobe adult (RPKM 42.2), CNS E18 (RPKM 41.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 G3; 6 75.41 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (143112592..143154272)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (143166866..143208546)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression of Etnk1 in the mouse hippocampus is modulated by a sequence variant (B2 SINE indel) in the 3' UTR of Comt (catechol-O-methyltransferase).
Title: A transposon in Comt generates mRNA variants and causes widespread expression and behavioral differences among mice.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH135943 (e-PCR)
- UniSTS:209939

RH125947 (e-PCR)
- UniSTS:162659

RH143348 (e-PCR)
- UniSTS:232595

BB377319 (e-PCR)
- UniSTS:208048

RH126992 (e-PCR)
- UniSTS:208049

Etnk1 (e-PCR), detects polymorphism
- UniSTS:546764

AI841245 (e-PCR)
- UniSTS:164343

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ethanolamine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ethanolamine kinase activity	IEA Inferred from Electronic Annotation more info
enables ethanolamine kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in phosphatidylethanolamine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylethanolamine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylethanolamine biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ethanolamine kinase 1

Names: EKI 1

NP_083526.2

EC 2.7.1.82

XP_006507074.1

EC 2.7.1.82

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_029250.2 → NP_083526.2 ethanolamine kinase 1

See identical proteins and their annotated locations for NP_083526.2

Status: VALIDATED

Source sequence(s)

AK044502, AK049691, BQ175711

Consensus CDS

CCDS57468.1

UniProtKB/Swiss-Prot

F6Y9V2, Q8BXQ0, Q9D4V0

UniProtKB/TrEMBL

Q8BWV4

Related

ENSMUSP00000032413.5, ENSMUST00000032413.7

Conserved Domains (2) summary

PLN02236
Location:26 → 356

PLN02236; choline kinase

cd05157
Location:49 → 351

ETNK_euk; Euykaryotic Ethanolamine kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

143112592..143154272

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006507011.5 → XP_006507074.1 ethanolamine kinase 1 isoform X1

UniProtKB/TrEMBL

A0A0N4SV10

Conserved Domains (1) summary

cd05157
Location:49 → 261

ETNK_euk; Euykaryotic Ethanolamine kinase