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    Art3 ADP-ribosyltransferase 3 [ Mus musculus (house mouse) ]

    Gene ID: 109979, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Art3provided by MGI
    Official Full Name
    ADP-ribosyltransferase 3provided by MGI
    Primary source
    MGI:MGI:1202729
    See related
    Ensembl:ENSMUSG00000034842 AllianceGenome:MGI:1202729
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ARTC3; 4930569O04Rik
    Summary
    Predicted to enable NAD+-protein poly-ADP-ribosyltransferase activity. Predicted to be located in plasma membrane and side of membrane. Is expressed in 1-cell stage embryo; 2-cell stage embryo; facial ganglion; glossopharyngeal ganglion; and vestibulo-cochlear ganglion. Orthologous to human ART3 (ADP-ribosyltransferase 3 (inactive)). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in bladder adult (RPKM 97.0), testis adult (RPKM 41.5) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Art3 in Genome Data Viewer
    Location:
    5 E2; 5 46.54 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (92479659..92562487)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (92331799..92414628)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene SDA1 domain containing 1 Neighboring gene predicted gene, 23031 Neighboring gene C-X-C motif chemokine ligand 9 Neighboring gene STARR-positive B cell enhancer mm9_chr5:92777801-92778102 Neighboring gene STARR-seq mESC enhancer starr_13640 Neighboring gene C-X-C motif chemokine ligand 10 Neighboring gene STARR-positive B cell enhancer ABC_E6346 Neighboring gene chemokine (C-X-C motif) ligand 11 Neighboring gene CWF19-like 1, cell cycle control pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E4766 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:92864208-92864361 Neighboring gene nucleoporin 54 Neighboring gene predicted gene, 42114 Neighboring gene scavenger receptor class B, member 2 Neighboring gene microRNA 6415

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genomic organization and expression of the human mono-ADP-ribosyltransferase ART3 gene. Friedrich M, et al. Biochim Biophys Acta, 2006 Jun. PMID 16934346
    2. Genome-wide assessments reveal extremely high levels of polymorphism of two active families of mouse endogenous retroviral elements. Zhang Y, et al. PLoS Genet, 2008 Feb 29. PMID 18454193, Free PMC Article
    3. WECHE: a novel hematopoietic regulatory factor. Ohneda O, et al. Immunity, 2000 Feb. PMID 10714680
    4. The first murine zygotic transcription is promiscuous and uncoupled from splicing and 3' processing. Abe K, et al. EMBO J, 2015 Jun 3. PMID 25896510, Free PMC Article
    5. DIO3 protects against thyrotoxicosis-derived cranio-encephalic and cardiac congenital abnormalities. Martinez ME, et al. JCI Insight, 2022 Nov 8. PMID 36166296, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Spontaneous (1)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NAD+-protein poly-ADP-ribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD+-protein-arginine ADP-ribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ecto-ADP-ribosyltransferase 3
    Names
    ADP-ribosyltransferase C2 and C3 toxin-like 3
    ART3 mono(ADP-ribosyl)transferase
    NAD(P)(+)--arginine ADP-ribosyltransferase 3
    mono(ADP-ribosyl)transferase 3
    NP_001297593.1
    NP_001297594.1
    NP_001357520.1
    NP_859417.2
    XP_006534769.1
    XP_006534770.1
    XP_006534771.1
    XP_006534772.1
    XP_006534773.1
    XP_006534774.1
    XP_006534775.1
    XP_006534776.1
    XP_006534777.1
    XP_006534779.1
    XP_006534781.1
    XP_006534782.1
    XP_006534783.1
    XP_006534784.1
    XP_030109908.1
    XP_030109909.1
    XP_030109910.1
    XP_030109911.1
    XP_030109912.1
    XP_030109913.1
    XP_030109914.1
    XP_036020621.1
    XP_036020622.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310664.1 → NP_001297593.1  ecto-ADP-ribosyltransferase 3 isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC122365, AK016257, AW123431
      Consensus CDS
      CCDS80328.1
      UniProtKB/TrEMBL
      B7ZNM3, E9QNU1
      Related
      ENSMUSP00000113510.2, ENSMUST00000121096.8
      Conserved Domains (1) summary
      cl00173
      Location:29 → 251
      VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

    2. NM_001310665.1 → NP_001297594.1  ecto-ADP-ribosyltransferase 3 isoform 3 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has a shorter 5' UTR, lacks three alternate in-frame exons, and contains an in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AC122365
      Consensus CDS
      CCDS84904.1
      UniProtKB/TrEMBL
      B7ZNM3
      Related
      ENSMUSP00000112648.2, ENSMUST00000119587.8
      Conserved Domains (1) summary
      cl00173
      Location:29 → 251
      VIP2; VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

    3. NM_001370591.1 → NP_001357520.1  ecto-ADP-ribosyltransferase 3 isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AC122365
      UniProtKB/Swiss-Prot
      B2RUC2, O54738, Q8R2F9, Q8R2G0, Q8R2G1, Q8R2G2, Q8R2G3, Q8R2G4
      UniProtKB/TrEMBL
      B7ZNM3
      Related
      ENSMUSP00000114083.2, ENSMUST00000118106.8
      Conserved Domains (1) summary
      cl00173
      Location:29 → 251
      VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

    4. NM_181728.3 → NP_859417.2  ecto-ADP-ribosyltransferase 3 isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has a shorter 5' UTR and lacks an alternate in-frame exon compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC122365
      Consensus CDS
      CCDS51546.1
      UniProtKB/TrEMBL
      B7ZNM3
      Related
      ENSMUSP00000113074.2, ENSMUST00000120193.8
      Conserved Domains (1) summary
      cl00173
      Location:29 → 251
      VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      92479659..92562487
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534707.4 → XP_006534770.1  ecto-ADP-ribosyltransferase 3 isoform X1

      UniProtKB/TrEMBL
      B7ZNM3
      Conserved Domains (1) summary
      cl00173
      Location:29 → 251
      VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

    2. XM_006534708.4 → XP_006534771.1  ecto-ADP-ribosyltransferase 3 isoform X1

      UniProtKB/TrEMBL
      B7ZNM3
      Conserved Domains (1) summary
      cl00173
      Location:29 → 251
      VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

    3. XM_006534712.4 → XP_006534775.1  ecto-ADP-ribosyltransferase 3 isoform X1

      UniProtKB/TrEMBL
      B7ZNM3
      Conserved Domains (1) summary
      cl00173
      Location:29 → 251
      VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

    4. XM_030254048.1 → XP_030109908.1  ecto-ADP-ribosyltransferase 3 isoform X5

      UniProtKB/Swiss-Prot
      B2RUC2, O54738, Q8R2F9, Q8R2G0, Q8R2G1, Q8R2G2, Q8R2G3, Q8R2G4
      UniProtKB/TrEMBL
      B7ZNM3
      Conserved Domains (1) summary
      cl00173
      Location:29 → 251
      VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

    5. XM_030254051.2 → XP_030109911.1  ecto-ADP-ribosyltransferase 3 isoform X7

      UniProtKB/TrEMBL
      B7ZNM3
      Related
      ENSMUSP00000108706.3, ENSMUST00000113083.9
      Conserved Domains (1) summary
      cl00173
      Location:29 → 251
      VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

    6. XM_030254052.2 → XP_030109912.1  ecto-ADP-ribosyltransferase 3 isoform X7

      UniProtKB/TrEMBL
      B7ZNM3
      Conserved Domains (1) summary
      cl00173
      Location:29 → 251
      VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

    7. XM_030254054.2 → XP_030109914.1  ecto-ADP-ribosyltransferase 3 isoform X7

      UniProtKB/TrEMBL
      B7ZNM3
      Conserved Domains (1) summary
      cl00173
      Location:29 → 251
      VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

    8. XM_030254053.1 → XP_030109913.1  ecto-ADP-ribosyltransferase 3 isoform X7

      UniProtKB/TrEMBL
      B7ZNM3
      Conserved Domains (1) summary
      cl00173
      Location:29 → 251
      VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

    9. XM_006534710.2 → XP_006534773.1  ecto-ADP-ribosyltransferase 3 isoform X1

      UniProtKB/TrEMBL
      B7ZNM3
      Conserved Domains (1) summary
      cl00173
      Location:29 → 251
      VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

    10. XM_036164729.1 → XP_036020622.1  ecto-ADP-ribosyltransferase 3 isoform X10

      UniProtKB/TrEMBL
      B7ZNM3
      Conserved Domains (1) summary
      cl00173
      Location:29 → 251
      VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

    11. XM_006534706.3 → XP_006534769.1  ecto-ADP-ribosyltransferase 3 isoform X1

      UniProtKB/TrEMBL
      B7ZNM3
      Conserved Domains (1) summary
      cl00173
      Location:29 → 251
      VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

    12. XM_006534713.4 → XP_006534776.1  ecto-ADP-ribosyltransferase 3 isoform X2

      UniProtKB/TrEMBL
      B7ZNM3
      Conserved Domains (1) summary
      cl00173
      Location:29 → 251
      VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

    13. XM_006534714.4 → XP_006534777.1  ecto-ADP-ribosyltransferase 3 isoform X3

      UniProtKB/TrEMBL
      B7ZNM3, E9QNU1
      Conserved Domains (1) summary
      cl00173
      Location:29 → 251
      VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

    14. XM_030254050.1 → XP_030109910.1  ecto-ADP-ribosyltransferase 3 isoform X6

      UniProtKB/TrEMBL
      A0A0R4J1Q4
      Conserved Domains (1) summary
      cl00173
      Location:29 → 251
      VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

    15. XM_006534718.4 → XP_006534781.1  ecto-ADP-ribosyltransferase 3 isoform X7

      UniProtKB/TrEMBL
      B7ZNM3
      Conserved Domains (1) summary
      cl00173
      Location:29 → 251
      VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

    16. XM_006534716.4 → XP_006534779.1  ecto-ADP-ribosyltransferase 3 isoform X4

      UniProtKB/TrEMBL
      B7ZNM3
      Conserved Domains (1) summary
      cl00173
      Location:29 → 251
      VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

    17. XM_006534719.4 → XP_006534782.1  ecto-ADP-ribosyltransferase 3 isoform X8

      UniProtKB/TrEMBL
      B7ZNM3
      Conserved Domains (1) summary
      cl00173
      Location:29 → 251
      VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

    18. XM_006534721.5 → XP_006534784.1  ecto-ADP-ribosyltransferase 3 isoform X11

      UniProtKB/TrEMBL
      B7ZNM3
      Conserved Domains (1) summary
      cl00173
      Location:29 → 251
      VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

    19. XM_006534720.4 → XP_006534783.1  ecto-ADP-ribosyltransferase 3 isoform X9

      UniProtKB/TrEMBL
      B7ZNM3
      Conserved Domains (1) summary
      cl00173
      Location:29 → 251
      VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

    20. XM_006534711.5 → XP_006534774.1  ecto-ADP-ribosyltransferase 3 isoform X1

      UniProtKB/TrEMBL
      B7ZNM3
      Conserved Domains (1) summary
      cl00173
      Location:29 → 251
      VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

    21. XM_030254049.2 → XP_030109909.1  ecto-ADP-ribosyltransferase 3 isoform X5

      UniProtKB/Swiss-Prot
      B2RUC2, O54738, Q8R2F9, Q8R2G0, Q8R2G1, Q8R2G2, Q8R2G3, Q8R2G4
      UniProtKB/TrEMBL
      B7ZNM3
      Conserved Domains (1) summary
      cl00173
      Location:29 → 251
      VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

    22. XM_006534709.5 → XP_006534772.1  ecto-ADP-ribosyltransferase 3 isoform X1

      UniProtKB/TrEMBL
      B7ZNM3
      Conserved Domains (1) summary
      cl00173
      Location:29 → 251
      VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

    23. XM_036164728.1 → XP_036020621.1  ecto-ADP-ribosyltransferase 3 isoform X7

      UniProtKB/TrEMBL
      B7ZNM3
      Conserved Domains (1) summary
      cl00173
      Location:29 → 251
      VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R2G4.2 GenPept UniProtKB/Swiss-Prot:Q8R2G4

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