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    Rragc Ras-related GTP binding C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298514, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Rragcprovided by RGD
    Official Full Name
    Ras-related GTP binding Cprovided by RGD
    Primary source
    RGD:1311760
    See related
    EnsemblRapid:ENSRNOG00000017426 AllianceGenome:RGD:1311760
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including GTPase binding activity; guanyl ribonucleotide binding activity; and protein heterodimerization activity. Predicted to be involved in several processes, including cellular response to amino acid starvation; positive regulation of TORC1 signaling; and protein localization to lysosome. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of FNIP-folliculin RagC/D GAP and Gtr1-Gtr2 GTPase complex. Predicted to be active in lysosomal membrane and nucleus. Orthologous to human RRAGC (Ras related GTP binding C). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 139.4), Spleen (RPKM 126.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rragc in Genome Data Viewer
    Location:
    5q36
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (141433014..141452546)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (136148239..136167773)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (141572536..141590784)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479028 Neighboring gene Myc binding protein Neighboring gene uncharacterized LOC120102974 Neighboring gene long non-coding RNA 081

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of variants in MBNL1 in patients with a myotonic dystrophy-like phenotype. Larsen M, et al. Eur J Hum Genet, 2016 Oct. PMID 27222292, Free PMC Article
    2. Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B. Sekiguchi T, et al. J Biol Chem, 2001 Mar 9. PMID 11073942
    3. Regulation of mTORC1 by amino acids. Bar-Peled L, et al. Trends Cell Biol, 2014 Jul. PMID 24698685, Free PMC Article
    4. Molecular mechanisms of mTOR-mediated translational control. Ma XM, et al. Nat Rev Mol Cell Biol, 2009 May. PMID 19339977
    5. Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway. Han JM, et al. Cell, 2012 Apr 13. PMID 22424946

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GDP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-membrane adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cellular response to amino acid starvation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to amino acid stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to nutrient levels ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to amino acid ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of FNIP-folliculin RagC/D GAP ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Gtr1-Gtr2 GTPase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ras-related GTP-binding protein C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001048184.1 → NP_001041649.1  ras-related GTP-binding protein C

      See identical proteins and their annotated locations for NP_001041649.1

      Status: PROVISIONAL

      Source sequence(s)
      BC105622
      UniProtKB/TrEMBL
      A6IS39, Q0D2L6
      Related
      ENSRNOP00000023514.5, ENSRNOT00000023514.7
      Conserved Domains (1) summary
      cd11385
      Location:62 → 236
      RagC_like; Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins C and D

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      141433014..141452546
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109616.2 → XP_038965544.1  ras-related GTP-binding protein C isoform X1

      UniProtKB/TrEMBL
      A6IS39
      Conserved Domains (1) summary
      cd11385
      Location:62 → 236
      RagC_like; Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins C and D
    Nucleotide Protein Strain
    Heading Accession and Version

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