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    bioC malonyl-acyl carrier protein methyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945388, updated on 17-Dec-2024

    Summary

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    Official Symbol
    bioC
    Official Full Name
    malonyl-acyl carrier protein methyltransferase
    Primary source
    ECOCYC:EG10119
    Locus tag
    b0777
    See related
    ASAP:ABE-0002648
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0766
    Summary
    BioC is involved in an early, biochemically undefined step of biotin biosynthesis . bioC mutants require biotin for growth and appear to be blocked before the synthesis of pimeloyl-CoA . [More information is available at EcoCyc: EG10119].
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    Genomic context

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    Sequence:
    NC_000913.3 (811522..812277)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene adenosylmethionine-8-amino-7-oxononanoate aminotransferase Neighboring gene biotin synthase Neighboring gene 8-amino-7-oxononanoate synthase Neighboring gene dethiobiotin synthetase Neighboring gene UvrABC excision nuclease subunit B Neighboring gene putative transferase YbhK

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biotin-requiring mutants of Escherichia coli K-12. Del Campillo-Campbell A, et al. J Bacteriol, 1967 Dec. PMID 4864413, Free PMC Article
    2. Origin of carbon atoms of biotin. 13C-NMR studies on biotin biosynthesis in Escherichia coli. Ifuku O, et al. Eur J Biochem, 1994 Mar 1. PMID 8125118
    3. Deletion and complementation analysis of biotin gene cluster of Escherichia coli. Cleary PP, et al. J Bacteriol, 1972 Nov. PMID 4563978, Free PMC Article
    4. Genetic and biochemical analysis of the biotin loci of Escherichia coli K-12. Rolfe B, et al. J Bacteriol, 1968 Aug. PMID 4877129, Free PMC Article
    5. Nucleotide sequence of the bioH gene of Escherichia coli. O'Regan M, et al. Nucleic Acids Res, 1989 Oct 11. PMID 2678009, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables S-adenosylmethionine-dependent methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carboxyl-O-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carboxyl-O-methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables malonyl-CoA methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biotin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within biotin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    malonyl-acyl carrier protein methyltransferase
    NP_415298.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      811522..812277
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415298.1 malonyl-acyl carrier protein methyltransferase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415298.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2X1QD91, A0A8S7BJY9
      Conserved Domains (1) summary
      PRK10258
      Location:1 → 251
      PRK10258; biotin biosynthesis protein BioC; Provisional
    Nucleotide Protein
    Heading Accession and Version

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