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    Ces2a carboxylesterase 2A [ Mus musculus (house mouse) ]

    Gene ID: 102022, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ces2aprovided by MGI
    Official Full Name
    carboxylesterase 2Aprovided by MGI
    Primary source
    MGI:MGI:2142491
    See related
    Ensembl:ENSMUSG00000055730 AllianceGenome:MGI:2142491
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ces6; 9130231C15Rik
    Summary
    Enables carboxylesterase activity. Acts upstream of or within protein glycosylation. Predicted to be located in endoplasmic reticulum. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in liver. Orthologous to human CES2 (carboxylesterase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver adult (RPKM 135.2), duodenum adult (RPKM 127.9) and 5 other tissues See more
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    Genomic context

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    See Ces2a in Genome Data Viewer
    Location:
    8 D3; 8 53.04 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (105460635..105468266)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (104734003..104741634)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene carboxylesterase 2A pseudogene Neighboring gene carboxylesterase 2E pseudogene Neighboring gene carboxylesterase 2 pseudogene Neighboring gene crumbs homolog 1 pseudogene Neighboring gene RIKEN cDNA 4932416K20 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Carboxylesterase 2a deletion provokes hepatic steatosis and insulin resistance in mice involving impaired diacylglycerol and lysophosphatidylcholine catabolism. Chalhoub G, et al. Mol Metab, 2023 Jun. PMID 37059417, Free PMC Article
    2. Identification, expression, and purification of a pyrethroid-hydrolyzing carboxylesterase from mouse liver microsomes. Stok JE, et al. J Biol Chem, 2004 Jul 9. PMID 15123619
    3. Fgf10 is an oncogene activated by MMTV insertional mutagenesis in mouse mammary tumors and overexpressed in a subset of human breast carcinomas. Theodorou V, et al. Oncogene, 2004 Aug 12. PMID 15208658
    4. Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins. Holmes RS, et al. Mamm Genome, 2010 Oct. PMID 20931200, Free PMC Article
    5. Postnatal liver functional maturation requires Cnot complex-mediated decay of mRNAs encoding cell cycle and immature liver genes. Suzuki T, et al. Development, 2019 Feb 15. PMID 30733279, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carboxylesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables carboxylesterase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables carboxylic ester hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables retinyl-palmitate esterase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables trans-permethrin hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in prostaglandin metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein glycosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in retinol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    pyrethroid hydrolase Ces2a
    Names
    carboxylesterase 6
    carboxylic ester hydrolase 2A
    NP_001177259.1
    NP_598721.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001190330.1 → NP_001177259.1  pyrethroid hydrolase Ces2a isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the CDS, as compared to variant 1. The resulting isoform (2) lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      AK078953, AK165784, BY088529, BY458169
      Consensus CDS
      CCDS52650.1
      UniProtKB/Swiss-Prot
      Q8QZR3
      Related
      ENSMUSP00000127346.3, ENSMUST00000164182.3
      Conserved Domains (2) summary
      COG0657
      Location:127 → 230
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam00135
      Location:30 → 504
      COesterase; Carboxylesterase family

    2. NM_133960.5 → NP_598721.1  pyrethroid hydrolase Ces2a isoform 1 precursor

      See identical proteins and their annotated locations for NP_598721.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK078953, BY088529, BY458169
      Consensus CDS
      CCDS22585.1
      UniProtKB/Swiss-Prot
      E9Q3D0, Q3TMR2, Q8QZR3
      Related
      ENSMUSP00000034346.8, ENSMUST00000034346.15
      Conserved Domains (2) summary
      COG0657
      Location:127 → 230
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam00135
      Location:30 → 537
      COesterase; Carboxylesterase family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      105460635..105468266
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8QZR3.1 GenPept UniProtKB/Swiss-Prot:Q8QZR3

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