Ces1g carboxylesterase 1G [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ces1gprovided by MGI
Official Full Name: carboxylesterase 1Gprovided by MGI
Primary source: MGI:MGI:88378
See related: Ensembl:ENSMUSG00000057074 AllianceGenome:MGI:88378
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CEH; Ces1; Ces-1; Ses-1
Summary: This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. The expression and activity of this gene is age-related but independent of growth hormone level. This gene is clustered with Ces7 and Ces3 on chromosome 8. [provided by RefSeq, Jun 2010]
Expression: Biased expression in liver adult (RPKM 42.5), colon adult (RPKM 3.1) and 1 other tissue See more
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Genomic context

Location:: 8 C5; 8 45.29 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (94028997..94063837, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (93302369..93337209, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Global loss of Ces1/Ces1g protects against the development of atherosclerosis.
Title: Global inactivation of carboxylesterase 1 (Ces1/Ces1g) protects against atherosclerosis in Ldlr (-/-) mice.
Loss of CES1 is associated with the susceptibility to high cholesterol diet-induced liver injury.
Title: Sortilin 1 Modulates Hepatic Cholesterol Lipotoxicity in Mice via Functional Interaction with Liver Carboxylesterase 1.
Hepatic Ces1g/Es-x plays a critical role in limiting hepatic steatosis, very low-density lipoprotein assembly and in augmenting insulin sensitivity.
Title: Liver-specific expression of carboxylesterase 1g/esterase-x reduces hepatic steatosis, counteracts dyslipidemia and improves insulin signaling.
Data indicate that organic anion-transporting polypeptides Oatp1a/1b-null mice had increased levels of carboxylesterase (Ces) enzymes, which caused higher conversion of irinotecan to SN-38 in plasma, potentially complicating pharmacokinetic analyses.
Title: OATP1A/1B transporters affect irinotecan and SN-38 pharmacokinetics and carboxylesterase expression in knockout and humanized transgenic mice.
Hepatic CES1 plays a critical role in regulating both lipid and carbohydrate metabolism and FXR-controlled lipid homeostasis
Title: Hepatic carboxylesterase 1 is essential for both normal and farnesoid X receptor-controlled lipid homeostasis.
Ces1/Es-x participates in the regulation of chylomicron assembly and secretion.
Title: Carboxylesterase1/Esterase-x regulates chylomicron production in mice.
These studies support a role for Ces1/Es-x in the partitioning of regulatory fatty acids and concomitant control of hepatic lipid biosynthesis, secretion, and deposition.
Title: Deficiency of carboxylesterase 1/esterase-x results in obesity, hepatic steatosis, and hyperlipidemia.
Es-x limits hepatic triacylglycerol accumulation by promoting beta-oxidation.
Title: Es-x/Ces1 prevents triacylglycerol accumulation in McArdle-RH7777 hepatocytes.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D8Mit163 (e-PCR), detects polymorphism
- UniSTS:131368

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carboxylesterase activity	IEA Inferred from Electronic Annotation more info
enables carboxylesterase activity	ISO Inferred from Sequence Orthology more info
enables carboxylic ester hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables sterol ester esterase activity	ISO Inferred from Sequence Orthology more info
enables sterol ester esterase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cellular response to cholesterol	ISO Inferred from Sequence Orthology more info
involved_in cellular response to low-density lipoprotein particle stimulus	ISO Inferred from Sequence Orthology more info
involved_in cholesterol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in cholesterol homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in cholesterol metabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within chylomicron assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in lipid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in medium-chain fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cholesterol storage	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cholesterol storage	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cholesterol efflux	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cholesterol efflux	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cholesterol metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of bile acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of bile acid biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of bile acid secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of bile acid secretion	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of chylomicron remnant clearance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of triglyceride metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed
involved_in reverse cholesterol transport	ISO Inferred from Sequence Orthology more info
involved_in reverse cholesterol transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum lumen	IEA Inferred from Electronic Annotation more info
is_active_in lipid droplet	IBA Inferred from Biological aspect of Ancestor more info
located_in lipid droplet	ISO Inferred from Sequence Orthology more info
located_in lipid droplet	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: liver carboxylesterase 1

Names: ES-x; acyl-coenzyme A:cholesterol acyltransferase; carboxylesterase 1; cholesteryl ester hydrolase

NP_067431.2

EC 3.1.1.1

EC 3.1.1.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021456.4 → NP_067431.2 liver carboxylesterase 1 precursor

See identical proteins and their annotated locations for NP_067431.2

Status: REVIEWED

Source sequence(s)

AI316467, AK136588

Consensus CDS

CCDS22531.1

UniProtKB/Swiss-Prot

O55136, Q8VCC2

UniProtKB/TrEMBL

Q3UW56

Related

ENSMUSP00000037555.8, ENSMUST00000044602.8

Conserved Domains (2) summary

COG0657
Location:121 → 239

Aes; Acetyl esterase/lipase [Lipid transport and metabolism]

pfam00135
Location:24 → 545

COesterase; Carboxylesterase family