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    pgpB phosphatidylglycerophosphatase B [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945863, updated on 3-Dec-2024

    Summary

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    Official Symbol
    pgpB
    Official Full Name
    phosphatidylglycerophosphatase B
    Primary source
    ECOCYC:EG10705
    Locus tag
    b1278
    See related
    ASAP:ABE-0004294
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1273
    Summary
    The pgpB gene is nonessential, but is synthetically lethal with a bacA ybjG double mutant, due to its UppP activity. ybjG, pgpB, and lpxT are paralogs. [More information is available at EcoGene: EG10705]. PgpB is one of three phosphatidylglycerophosphatase (PGP-ase) activities in Escherichia coli. [More information is available at EcoCyc: EG10705].
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    Genomic context

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    Sequence:
    NC_000913.3 (1339330..1340094)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene aconitate hydratase 1 Neighboring gene GTP cyclohydrolase 2 Neighboring gene lipopolysaccharide assembly protein A Neighboring gene lipopolysaccharide assembly protein B

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Substrate specificity and membrane topology of Escherichia coli PgpB, an undecaprenyl pyrophosphate phosphatase. Touzé T, et al. J Biol Chem, 2008 Jun 13. PMID 18411271
    2. Structural Insight into Substrate Selection and Catalysis of Lipid Phosphate Phosphatase PgpB in the Cell Membrane. Tong S, et al. J Biol Chem, 2016 Aug 26. PMID 27405756, Free PMC Article
    3. Membrane-bound phosphatases in Escherichia coli: sequence of the pgpB gene and dual subcellular localization of the pgpB product. Icho T. J Bacteriol, 1988 Nov. PMID 2846511, Free PMC Article
    4. The Escherichia coli pgpB gene encodes for a diacylglycerol pyrophosphate phosphatase activity. Dillon DA, et al. J Biol Chem, 1996 Nov 29. PMID 8940025
    5. Multiple genes for membrane-bound phosphatases in Escherichia coli and their action on phospholipid precursors. Icho T, et al. J Bacteriol, 1983 Feb. PMID 6296050, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These studies reveal new mechanisms of lipid substrate selection and catalysis by PgpB and suggest that the enzyme rests in a PE-stabilized state in the bilayer.
      Title: Structural Insight into Substrate Selection and Catalysis of Lipid Phosphate Phosphatase PgpB in the Cell Membrane.
    2. analysis of substrate specificity and membrane topology of Escherichia coli PgpB, an undecaprenyl pyrophosphate phosphatase
      Title: Substrate specificity and membrane topology of Escherichia coli PgpB, an undecaprenyl pyrophosphate phosphatase.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables diacylglycerol diphosphate phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidate phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylglycerophosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylglycerophosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables undecaprenyl-diphosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables undecaprenyl-diphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables undecaprenyl-diphosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within glycerophospholipid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within peptidoglycan biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphatidylglycerol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell outer membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphatidylglycerophosphatase B
    NP_415794.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1339330..1340094
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415794.1 phosphatidylglycerophosphatase B [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415794.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376THP3, A0A895NV98
      Conserved Domains (1) summary
      PRK10699
      Location:1 → 244
      PRK10699; phosphatidylglycerophosphatase B; Provisional
    Nucleotide Protein
    Heading Accession and Version

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