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    pmrD signal transduction protein PmrD [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945130, updated on 17-Dec-2024

    Summary

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    Official Symbol
    pmrD
    Official Full Name
    signal transduction protein PmrD
    Primary source
    ECOCYC:G7172
    Locus tag
    b2259
    See related
    ASAP:ABE-0007468
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2253
    Summary
    In Salmonella but not Escherichia coli, low Mg(2+) PhoP-activated PmrD controls PmrA(BasR)/PmrB(BasS) activity post-translationally by binding to phospho-PmrA(BasR) and inhibiting its dephosphorylation but not its phosphotransfer, connecting the PhoPQ and PmrAB two-component systems and allowing for an amplified and persistent PmrAB response (Kato, 2007). [More information is available at EcoGene: EG12671]. PmrD is similar to the Salmonella enterica serovar Typhimurium PmrD, which confers resistance to polymyxin B when it is overexpressed ; in Salmonella, PmrD controls the activity of the PmrA-PmrB two-component system at a post-transcriptional level . [More information is available at EcoCyc: G7172].
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    Genomic context

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    Sequence:
    NC_000913.3 (2373272..2373538, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene fused UDP-4-amino-4-deoxy-L-arabinose formyltransferase/UDP-glucuronate dehydrogenase Neighboring gene putative 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD Neighboring gene lipid IVA 4-amino-4-deoxy-L-arabinosyltransferase Neighboring gene undecaprenyl-phosphate-alpha-L-Ara4N flippase - ArnE subunit Neighboring gene undecaprenyl-phosphate-alpha-L-Ara4N flippase - ArnF subunit Neighboring gene o-succinylbenzoate--CoA ligase Neighboring gene o-succinylbenzoate synthase Neighboring gene 1,4-dihydroxy-2-naphthoyl-CoA synthase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel mechanism for connecting bacterial two-component signal-transduction systems. Eguchi Y, et al. Trends Biochem Sci, 2005 Feb. PMID 15691651
    2. Isolation and characterization of a gene, pmrD, from Salmonella typhimurium that confers resistance to polymyxin when expressed in multiple copies. Roland KL, et al. J Bacteriol, 1994 Jun. PMID 8206837, Free PMC Article
    3. Connecting two-component regulatory systems by a protein that protects a response regulator from dephosphorylation by its cognate sensor. Kato A, et al. Genes Dev, 2004 Sep 15. PMID 15371344, Free PMC Article
    4. PmrD is required for modifications to escherichia coli endotoxin that promote antimicrobial resistance. Rubin EJ, et al. Antimicrob Agents Chemother, 2015 Apr. PMID 25605366, Free PMC Article
    5. A connector of two-component regulatory systems promotes signal amplification and persistence of expression. Kato A, et al. Proc Natl Acad Sci U S A, 2007 Jul 17. PMID 17615238, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Process Evidence Code Pubs
    involved_in response to antibiotic IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    signal transduction protein PmrD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2373272..2373538 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416762.2 signal transduction protein PmrD [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416762.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A1X3JF27, A0AAN3M9J9
      Conserved Domains (1) summary
      PRK15450
      Location:1 → 85
      PRK15450; signal transduction protein PmrD; Provisional
    Nucleotide Protein
    Heading Accession and Version

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