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    sspA stringent starvation protein A [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 944744, updated on 3-Dec-2024

    Summary

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    Official Symbol
    sspA
    Official Full Name
    stringent starvation protein A
    Primary source
    ECOCYC:EG10977
    Locus tag
    b3229
    See related
    ASAP:ABE-0010594
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3218; pog; ssp
    Summary
    The SspA protein is associated with RNA polymerase and is required for transcriptional activation of the bacteriophage P1 late promoter in vivo and in vitro . [More information is available at EcoCyc: EG10977].
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    Genomic context

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    Sequence:
    NC_000913.3 (3376782..3377420, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative transporter DcuD Neighboring gene ClpXP protease specificity-enhancing factor Neighboring gene 30S ribosomal subunit protein S9 Neighboring gene 50S ribosomal subunit protein L13

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Subunits of RNA polymerase in function and structure. IX. Regulation of RNA polymerase activity by stringent starvation protein (SSP). Ishihama A, et al. J Mol Biol, 1979 Apr 25. PMID 383996
    2. Biosynthetic regulation of individual proteins in relA+ and relA strains of Escherichia coli during amino acid starvation. Reeh S, et al. Mol Gen Genet, 1976 Dec 22. PMID 799246
    3. Genetic mapping of the Escherichia coli gene for the stringent starvation protein and its dispensability for normal cell growth. Fukuda R, et al. Mol Gen Genet, 1988 Mar. PMID 2835636
    4. Cloning of the Escherichia coli gene for the stringent starvation protein. Fukuda R, et al. Mol Gen Genet, 1985. PMID 3003520
    5. Structural basis for the function of stringent starvation protein a as a transcription factor. Hansen AM, et al. J Biol Chem, 2005 Apr 29. PMID 15735307

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Electrophysiological analysis revealed that SspA auto-inserts into lipid bilayers and forms IAA-94-sensitive ion channels. Substituting the ubiquitously conserved residue leucine 29 to alanine in the pore-forming region increased its single-channel conductance.
      Title: Identification and Characterization of a Bacterial Homolog of Chloride Intracellular Channel (CLIC) Protein.
    2. SspA positively regulates the expression of enterohemorrhagic Escherichia coli virulence factors by restricting the intracellular level of H-NS.
      Title: SspA up-regulates gene expression of the LEE pathogenicity island by decreasing H-NS levels in enterohemorrhagic Escherichia coli.
    3. N-terminus verified by Edman degradation on mature peptide
      Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
    4. SspA is a global regulator, which acts upstream of H-NS, and thereby plays an important role in the stress response of E. coli during stationary phase
      Title: SspA is required for acid resistance in stationary phase by downregulation of H-NS in Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to starvation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    stringent starvation protein A

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3376782..3377420 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417696.1 stringent starvation protein A [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417696.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S0FK24
      Conserved Domains (1) summary
      PRK09481
      Location:1 → 211
      sspA; stringent starvation protein A; Provisional
    Nucleotide Protein
    Heading Accession and Version

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