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    Minpp1 multiple inositol polyphosphate histidine phosphatase 1 [ Mus musculus (house mouse) ]

    Gene ID: 17330, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Minpp1provided by MGI
    Official Full Name
    multiple inositol polyphosphate histidine phosphatase 1provided by MGI
    Primary source
    MGI:MGI:1336159
    See related
    Ensembl:ENSMUSG00000024896 AllianceGenome:MGI:1336159
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables inositol phosphate phosphatase activity. Is active in endoplasmic reticulum lumen and plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in papillary thyroid carcinoma and pontocerebellar hypoplasia type 16. Orthologous to human MINPP1 (multiple inositol-polyphosphate phosphatase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 47.9), duodenum adult (RPKM 37.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Minpp1 in Genome Data Viewer
    Location:
    19 C1; 19 27.25 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (32463169..32492770)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (32485769..32515370)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L9, pseudogene 6 Neighboring gene predicted gene, 46659 Neighboring gene STARR-seq mESC enhancer starr_45949 Neighboring gene predicted gene, 36419 Neighboring gene 3'-phosphoadenosine 5'-phosphosulfate synthase 2 Neighboring gene STARR-seq mESC enhancer starr_45950 Neighboring gene predicted gene, 36492

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. MINPP1 prevents intracellular accumulation of the chelator inositol hexakisphosphate and is mutated in Pontocerebellar Hypoplasia. Ucuncu E, et al. Nat Commun, 2020 Nov 30. PMID 33257696, Free PMC Article
    2. Targeted deletion of Minpp1 provides new insight into the activity of multiple inositol polyphosphate phosphatase in vivo. Chi H, et al. Mol Cell Biol, 2000 Sep. PMID 10938126, Free PMC Article
    3. Multiple inositol polyphosphate phosphatase: evolution as a distinct group within the histidine phosphatase family and chromosomal localization of the human and mouse genes to chromosomes 10q23 and 19. Chi H, et al. Genomics, 1999 Mar 15. PMID 10087200
    4. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MINPP1 prevents intracellular accumulation of the chelator inositol hexakisphosphate and is mutated in Pontocerebellar Hypoplasia.
      Title: MINPP1 prevents intracellular accumulation of the chelator inositol hexakisphosphate and is mutated in Pontocerebellar Hypoplasia.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-phytase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 4-phytase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acid phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables bisphosphoglycerate 3-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables bisphosphoglycerate 3-phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables inositol bisphosphate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables inositol bisphosphate phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables inositol pentakisphosphate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables inositol pentakisphosphate phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables inositol phosphate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inositol phosphate phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables inositol phosphate phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables inositol trisphosphate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables inositol trisphosphate phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables inositol-hexakisphosphate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables inositol-hexakisphosphate phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    NOT involved_in bone mineralization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of intracellular monoatomic cation homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of intracellular monoatomic cation homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of intracellular monoatomic cation homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    NOT involved_in ossification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum lumen IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    multiple inositol polyphosphate phosphatase 1
    Names
    2,3-BPG phosphatase
    2,3-bisphosphoglycerate 3-phosphatase
    inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase
    ins(1,3,4,5)P(4) 3-phosphatase
    NP_034929.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010799.2 → NP_034929.1  multiple inositol polyphosphate phosphatase 1 precursor

      See identical proteins and their annotated locations for NP_034929.1

      Status: VALIDATED

      Source sequence(s)
      AC115752, AK151486, AV297692
      Consensus CDS
      CCDS29751.1
      UniProtKB/Swiss-Prot
      Q3UA76, Q8VDR0, Q9JJD5, Q9Z2L6
      Related
      ENSMUSP00000025827.9, ENSMUST00000025827.10
      Conserved Domains (1) summary
      cd07061
      Location:82 → 429
      HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      32463169..32492770
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z2L6.3 GenPept UniProtKB/Swiss-Prot:Q9Z2L6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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