Ppwd1 peptidylprolyl isomerase domain and WD repeat containing 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ppwd1provided by MGI
Official Full Name: peptidylprolyl isomerase domain and WD repeat containing 1provided by MGI
Primary source: MGI:MGI:2443069
See related: Ensembl:ENSMUSG00000021713 AllianceGenome:MGI:2443069
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4632422M10Rik; A330090G21Rik
Summary: Predicted to enable cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding and protein peptidyl-prolyl isomerization. Predicted to be located in nuclear body. Predicted to be part of catalytic step 2 spliceosome. Orthologous to human PPWD1 (peptidylprolyl isomerase domain and WD repeat containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in CNS E11.5 (RPKM 6.8), liver E14 (RPKM 4.5) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 D1; 13 56.39 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (104340102..104365378, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (104203594..104228844, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA polymerase II CTD heptapeptide repeat P3 isomerase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat P6 isomerase activity	IEA Inferred from Electronic Annotation more info
enables cyclosporin A binding	ISO Inferred from Sequence Orthology more info
enables peptidyl-prolyl cis-trans isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptidyl-prolyl cis-trans isomerase activity	ISO Inferred from Sequence Orthology more info
enables peptidyl-prolyl cis-trans isomerase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein peptidyl-prolyl isomerization	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of catalytic step 2 spliceosome	IEA Inferred from Electronic Annotation more info
part_of catalytic step 2 spliceosome	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: peptidylprolyl isomerase domain and WD repeat-containing protein 1

NP_766395.2

EC 5.2.1.8

XP_011242960.1

EC 5.2.1.8

XP_017171002.1

EC 5.2.1.8

XP_017171003.1

EC 5.2.1.8

XP_017171004.1

EC 5.2.1.8

XP_036013937.1

EC 5.2.1.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172807.4 → NP_766395.2 peptidylprolyl isomerase domain and WD repeat-containing protein 1

See identical proteins and their annotated locations for NP_766395.2

Status: VALIDATED

Source sequence(s)

AC154216, AK028532, AK043316

Consensus CDS

CCDS26748.1

UniProtKB/Swiss-Prot

Q0VEA0, Q8CEC6

Related

ENSMUSP00000022226.5, ENSMUST00000022226.6

Conserved Domains (4) summary

COG2319
Location:89 → 311

WD40; WD40 repeat [General function prediction only]

cd01927
Location:495 → 643

cyclophilin_WD40; cyclophilin_WD40: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) having a WD40 domain. This group consists of several hypothetical and putative eukaryotic and bacterial proteins which have a cyclophilin domain and a WD40 domain. ...

sd00039
Location:136 → 177

7WD40; WD40 repeat [structural motif]

cl02567
Location:89 → 318

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

104340102..104365378 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011244658.3 → XP_011242960.1 peptidylprolyl isomerase domain and WD repeat-containing protein 1 isoform X4

Conserved Domains (4) summary

COG2319
Location:19 → 176

WD40; WD40 repeat [General function prediction only]

cd01927
Location:355 → 503

cyclophilin_WD40; cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) having a WD40 domain. This group consists of several hypothetical and putative eukaryotic and bacterial proteins which have a cyclophilin domain and a WD40 domain. Function of the ...

sd00039
Location:39 → 81

7WD40; WD40 repeat [structural motif]

cl29593
Location:125 → 252

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_017315515.3 → XP_017171004.1 peptidylprolyl isomerase domain and WD repeat-containing protein 1 isoform X3

Conserved Domains (1) summary

cd01927
Location:172 → 320

cyclophilin_WD40; cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) having a WD40 domain. This group consists of several hypothetical and putative eukaryotic and bacterial proteins which have a cyclophilin domain and a WD40 domain. Function of the ...
XM_017315514.3 → XP_017171003.1 peptidylprolyl isomerase domain and WD repeat-containing protein 1 isoform X3

Conserved Domains (1) summary

cd01927
Location:172 → 320

cyclophilin_WD40; cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) having a WD40 domain. This group consists of several hypothetical and putative eukaryotic and bacterial proteins which have a cyclophilin domain and a WD40 domain. Function of the ...
XM_036158044.1 → XP_036013937.1 peptidylprolyl isomerase domain and WD repeat-containing protein 1 isoform X1

Conserved Domains (3) summary

cd01927
Location:414 → 562

cyclophilin_WD40; cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) having a WD40 domain. This group consists of several hypothetical and putative eukaryotic and bacterial proteins which have a cyclophilin domain and a WD40 domain. Function of the ...

sd00039
Location:55 → 96

7WD40; WD40 repeat [structural motif]

cl29593
Location:8 → 237

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_017315513.2 → XP_017171002.1 peptidylprolyl isomerase domain and WD repeat-containing protein 1 isoform X2

Conserved Domains (4) summary

COG2319
Location:39 → 160

WD40; WD40 repeat [General function prediction only]

cd01927
Location:339 → 487

cyclophilin_WD40; cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) having a WD40 domain. This group consists of several hypothetical and putative eukaryotic and bacterial proteins which have a cyclophilin domain and a WD40 domain. Function of the ...

sd00039
Location:23 → 65

7WD40; WD40 repeat [structural motif]

cl29593
Location:109 → 236

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...