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    Ptdss2 phosphatidylserine synthase 2 [ Mus musculus (house mouse) ]

    Gene ID: 27388, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ptdss2provided by MGI
    Official Full Name
    phosphatidylserine synthase 2provided by MGI
    Primary source
    MGI:MGI:1351664
    See related
    Ensembl:ENSMUSG00000025495 AllianceGenome:MGI:1351664
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PSS2
    Summary
    Enables CDP-diacylglycerol-serine O-phosphatidyltransferase activity and L-serine-phosphatidylethanolamine phosphatidyltransferase activity. Acts upstream of or within phosphatidylserine biosynthetic process. Located in endoplasmic reticulum membrane. Is expressed in several structures, including genitourinary system; hemolymphoid system; liver; lung; and nervous system. Orthologous to human PTDSS2 (phosphatidylserine synthase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis adult (RPKM 133.4), liver E14.5 (RPKM 36.5) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ptdss2 in Genome Data Viewer
    Location:
    7 F5; 7 86.39 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (140711181..140736071)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (141131267..141156158)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene anoctamin 9 Neighboring gene STARR-positive B cell enhancer ABC_E451 Neighboring gene predicted gene, 33560 Neighboring gene ribonuclease/angiogenin inhibitor 1 Neighboring gene STARR-positive B cell enhancer ABC_E8222 Neighboring gene STARR-positive B cell enhancer ABC_E9715 Neighboring gene ribosomal protein S9 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Phospholipid homeostasis in phosphatidylserine synthase-2-deficient mice. Steenbergen R, et al. Biochim Biophys Acta, 2006 Mar. PMID 16627002
    2. Phosphatidylserine synthase 2: high efficiency for synthesizing phosphatidylserine containing docosahexaenoic acid. Kimura AK, et al. J Lipid Res, 2013 Jan. PMID 23071296, Free PMC Article
    3. Cloning and expression of murine liver phosphatidylserine synthase (PSS)-2: differential regulation of phospholipid metabolism by PSS1 and PSS2. Stone SJ, et al. Biochem J, 1999 Aug 15. PMID 10432300, Free PMC Article
    4. Defining the importance of phosphatidylserine synthase-1 (PSS1): unexpected viability of PSS1-deficient mice. Arikketh D, et al. J Biol Chem, 2008 May 9. PMID 18343815
    5. Defining the importance of phosphatidylserine synthase 2 in mice. Bergo MO, et al. J Biol Chem, 2002 Dec 6. PMID 12361952

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables CDP-diacylglycerol-serine O-phosphatidyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables L-serine-phosphatidylethanolamine phosphatidyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-serine-phosphatidylethanolamine phosphatidyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in phosphatidylserine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphatidylserine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphatidylserine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular anatomical structure IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphatidylserine synthase 2
    Names
    PSS-2
    ptdSer synthase 2
    serine-exchange enzyme II
    NP_001405348.1
    NP_001405349.1
    NP_038810.2
    XP_006536259.1
    XP_006536260.1
    XP_030098495.1
    XP_030098496.1
    XP_030098497.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418419.1 → NP_001405348.1  phosphatidylserine synthase 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC108908, AC109272
      Related
      ENSMUST00000173721.8

    2. NM_001418420.1 → NP_001405349.1  phosphatidylserine synthase 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC108908, AC109272

    3. NM_013782.5 → NP_038810.2  phosphatidylserine synthase 2 isoform 1

      See identical proteins and their annotated locations for NP_038810.2

      Status: VALIDATED

      Source sequence(s)
      AC108908, AC109272
      Consensus CDS
      CCDS22001.1
      UniProtKB/Swiss-Prot
      Q8BHL2, Q8CCI8, Q8CCY7, Q922A1, Q9CY68, Q9Z1X2
      Related
      ENSMUSP00000026568.9, ENSMUST00000026568.10
      Conserved Domains (1) summary
      pfam03034
      Location:98 → 377
      PSS; Phosphatidyl serine synthase

    RNA

    1. NR_184740.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108908, AC109272

    2. NR_184741.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108908, AC109272

    3. NR_184742.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108908, AC109272

    4. NR_184743.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108908, AC109272

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      140711181..140736071
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242637.2 → XP_030098497.1  phosphatidylserine synthase 2 isoform X2

      Conserved Domains (1) summary
      pfam03034
      Location:1 → 191
      PSS; Phosphatidyl serine synthase

    2. XM_006536196.5 → XP_006536259.1  phosphatidylserine synthase 2 isoform X1

      Conserved Domains (1) summary
      pfam03034
      Location:55 → 308
      PSS; Phosphatidyl serine synthase

    3. XM_030242635.1 → XP_030098495.1  phosphatidylserine synthase 2 isoform X2

      Conserved Domains (1) summary
      pfam03034
      Location:1 → 191
      PSS; Phosphatidyl serine synthase

    4. XM_006536197.2 → XP_006536260.1  phosphatidylserine synthase 2 isoform X2

      See identical proteins and their annotated locations for XP_006536260.1

      Conserved Domains (1) summary
      pfam03034
      Location:1 → 191
      PSS; Phosphatidyl serine synthase

    5. XM_030242636.1 → XP_030098496.1  phosphatidylserine synthase 2 isoform X2

      Conserved Domains (1) summary
      pfam03034
      Location:1 → 191
      PSS; Phosphatidyl serine synthase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z1X2.2 GenPept UniProtKB/Swiss-Prot:Q9Z1X2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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