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    ariR putative two-component system connector protein AriR [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945340, updated on 3-Dec-2024

    Summary

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    Official Symbol
    ariR
    Official Full Name
    putative two-component system connector protein AriR
    Primary source
    ECOCYC:G6606
    Locus tag
    b1166
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1153; ymgB
    Summary
    AriR(YmgB) is a global regulator that is upregulated by cytoplasmic pH stress (Kannan, 2008). [More information is available at EcoGene: EG14290]. AriR appears to be a regulator of acid resistance and biofilm formation. [More information is available at EcoCyc: G6606].
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    Genomic context

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    Sequence:
    NC_000913.3 (1216369..1216635)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative two-component system connector protein YcgZ Neighboring gene putative two-component system connector protein YmgA Neighboring gene protein YmgC Neighboring gene putative c-di-GMP phosphodiesterase PdeG

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. 5-Fluorouracil reduces biofilm formation in Escherichia coli K-12 through global regulator AriR as an antivirulence compound. Attila C, et al. Appl Microbiol Biotechnol, 2009 Mar. PMID 19172264
    2. The Escherichia coli MarA protein regulates the ycgZ-ymgABC operon to inhibit biofilm formation. Kettles RA, et al. Mol Microbiol, 2019 Nov. PMID 31518447, Free PMC Article
    3. Differential gene expression shows natural brominated furanones interfere with the autoinducer-2 bacterial signaling system of Escherichia coli. Ren D, et al. Biotechnol Bioeng, 2004 Dec 5. PMID 15470704
    4. Low temperature (23 degrees C) increases expression of biofilm-, cold-shock- and RpoS-dependent genes in Escherichia coli K-12. White-Ziegler CA, et al. Microbiology (Reading), 2008 Jan. PMID 18174134
    5. Rapid acid treatment of Escherichia coli: transcriptomic response and recovery. Kannan G, et al. BMC Microbiol, 2008 Feb 26. PMID 18302792, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. 5-FU inhibit biofilm formation through the global regulator, AriR.
      Title: 5-Fluorouracil reduces biofilm formation in Escherichia coli K-12 through global regulator AriR as an antivirulence compound.
    2. Data show that YmgB represses biofilm formation in rich medium containing glucose, decreases cellular motility, and protects the cell from acid indicating that YmgB has a major role in acid-resistance in E. coli.
      Title: Structure and function of the Escherichia coli protein YmgB: a protein critical for biofilm formation and acid-resistance.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to acidic pH IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to hydrogen peroxide IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within single-species biofilm formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    putative two-component system connector protein AriR

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1216369..1216635
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415684.1 putative two-component system connector protein AriR [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415684.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0AAE9QBU7
      Conserved Domains (1) summary
      pfam10798
      Location:29 → 87
      YmgB; Biofilm development protein YmgB/AriR
    Nucleotide Protein
    Heading Accession and Version

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