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    Pnpt1 polyribonucleotide nucleotidyltransferase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360992, updated on 27-Nov-2024

    Summary

    Official Symbol
    Pnpt1provided by RGD
    Official Full Name
    polyribonucleotide nucleotidyltransferase 1provided by RGD
    Primary source
    RGD:1307987
    See related
    EnsemblRapid:ENSRNOG00000003600 AllianceGenome:RGD:1307987
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables polyribonucleotide nucleotidyltransferase activity. Involved in several processes, including liver regeneration; response to cAMP; and response to growth hormone. Located in endoplasmic reticulum membrane and ribosome. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 70; combined oxidative phosphorylation deficiency 13; and spinocerebellar ataxia type 25. Orthologous to human PNPT1 (polyribonucleotide nucleotidyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 161.7), Heart (RPKM 160.6) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Pnpt1 in Genome Data Viewer
    Location:
    14q22
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (107078486..107109628)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (102877553..102908696)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (113530470..113561645)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene EGF containing fibulin extracellular matrix protein 1 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene protein phosphatase 4, regulatory subunit 3B Neighboring gene uncharacterized LOC134481880 Neighboring gene cilia and flagella associated protein 36

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3'-5'-RNA exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables 3'-5'-RNA exonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables miRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables poly(G) binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables poly(U) RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables polyribonucleotide nucleotidyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables polyribonucleotide nucleotidyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables polyribonucleotide nucleotidyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in RNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in RNA import into mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to interferon-beta ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in liver regeneration IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in mRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitochondrial RNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitochondrial RNA 3'-end processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitochondrial RNA 5'-end processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitochondrial RNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitochondrial mRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitochondrial mRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitochondrial mRNA polyadenylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nuclear polyadenylation-dependent mRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mRNA catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of mRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of miRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mitochondrial RNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein homotrimerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in rRNA import into mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cellular respiration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cellular senescence ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to cAMP IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to growth hormone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of mitochondrial degradosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial intermembrane space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ribosome IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    polyribonucleotide nucleotidyltransferase 1, mitochondrial
    NP_001135843.1
    XP_038948164.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142371.1NP_001135843.1  polyribonucleotide nucleotidyltransferase 1, mitochondrial

      See identical proteins and their annotated locations for NP_001135843.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A8I5ZRL9, A6JQA4, G3V6G7
      Related
      ENSRNOP00000004919.5, ENSRNOT00000004919.7
      Conserved Domains (1) summary
      PRK11824
      Location:47752
      PRK11824; polynucleotide phosphorylase/polyadenylase; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      107078486..107109628
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039092236.2XP_038948164.1  polyribonucleotide nucleotidyltransferase 1, mitochondrial isoform X1

      Conserved Domains (1) summary
      PRK11824
      Location:11590
      PRK11824; polynucleotide phosphorylase/polyadenylase; Provisional