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    erpA iron-sulfur cluster insertion protein ErpA [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 944857, updated on 3-Dec-2024

    Summary

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    Official Symbol
    erpA
    Official Full Name
    iron-sulfur cluster insertion protein ErpA
    Primary source
    ECOCYC:EG12332
    Locus tag
    b0156
    See related
    ASAP:ABE-0000538
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0155; yadR
    Summary
    ErpA is required for respiratory growth and erpA mutants have reduced ubiquinone and menaquinone and can transfer Fe-S clusters to apo-IspG (Loiseau, 2007). iscA, sufA, erpA, and nfuA are paralogs. [More information is available at EcoGene: EG12332]. ErpA is an A-type iron-sulfur protein; it can bind both [2Fe-2S] and [4Fe-4S] clusters. [More information is available at EcoCyc: EG12332].
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    Genomic context

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    Sequence:
    NC_000913.3 (176610..176954)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene protein YadX Neighboring gene chloride:H(+) antiporter ClcA Neighboring gene protein YadW Neighboring gene PF03458 family protein YadS Neighboring gene vitamin B12 ABC transporter periplasmic binding protein Neighboring gene 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The ErpA/NfuA complex builds an oxidation-resistant Fe-S cluster delivery pathway. Py B, et al. J Biol Chem, 2018 May 18. PMID 29626095, Free PMC Article
    2. A-type carrier protein ErpA is essential for formation of an active formate-nitrate respiratory pathway in Escherichia coli K-12. Pinske C, et al. J Bacteriol, 2012 Jan. PMID 22081393, Free PMC Article
    3. Escherichia coli monothiol glutaredoxin GrxD replenishes Fe-S clusters to the essential ErpA A-type carrier under low iron stress. Fisher CE, et al. J Biol Chem, 2024 Aug. PMID 38944118, Free PMC Article
    4. ErpA, an iron sulfur (Fe S) protein of the A-type essential for respiratory metabolism in Escherichia coli. Loiseau L, et al. Proc Natl Acad Sci U S A, 2007 Aug 21. PMID 17698959, Free PMC Article
    5. Iron-sulfur (Fe/S) protein biogenesis: phylogenomic and genetic studies of A-type carriers. Vinella D, et al. PLoS Genet, 2009 May. PMID 19478995, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Escherichia coli monothiol glutaredoxin GrxD replenishes Fe-S clusters to the essential ErpA A-type carrier under low iron stress.
      Title: Escherichia coli monothiol glutaredoxin GrxD replenishes Fe-S clusters to the essential ErpA A-type carrier under low iron stress.
    2. These findings suggest that ErpA and IscA have overlapping roles in assembly of these anaerobic respiratory enzymes but demonstrate that ErpA is essential for the production of active enzymes.
      Title: A-type carrier protein ErpA is essential for formation of an active formate-nitrate respiratory pathway in Escherichia coli K-12.
    3. Under aerobiosis, IscA and SufA are functionally redundant carriers and both can receive an Fe/S cluster from IscU.
      Title: Iron-sulfur (Fe/S) protein biogenesis: phylogenomic and genetic studies of A-type carriers.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 2 iron, 2 sulfur cluster binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 2 iron, 2 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 4 iron, 4 sulfur cluster binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 4 iron, 4 sulfur cluster binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables iron ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within aerobic respiration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within anaerobic respiration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in iron-sulfur cluster assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within iron-sulfur cluster assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in iron-sulfur cluster assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein maturation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein maturation by [4Fe-4S] cluster transfer IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein maturation by [4Fe-4S] cluster transfer IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within protein maturation by [4Fe-4S] cluster transfer IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    iron-sulfur cluster insertion protein ErpA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      176610..176954
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414698.1 iron-sulfur cluster insertion protein ErpA [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414698.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9APL5
      Conserved Domains (1) summary
      PRK13623
      Location:1 → 114
      PRK13623; iron-sulfur cluster insertion protein ErpA; Provisional
    Nucleotide Protein
    Heading Accession and Version

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