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    dacD D-alanyl-D-alanine carboxypeptidase DacD [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946518, updated on 17-Dec-2024

    Summary

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    Official Symbol
    dacD
    Official Full Name
    D-alanyl-D-alanine carboxypeptidase DacD
    Primary source
    ECOCYC:EG11893
    Locus tag
    b2010
    See related
    ASAP:ABE-0006680
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2004; phsE; yeeC
    Summary
    First 21 aa predicted to be a type I signal peptide. [More information is available at EcoGene: EG11893]. DacD, also called penicillin-binding protein 6b (PBP6b), is a D-alanyl-D-alanine carboxypeptidase and penicillin-binding protein with sequence similarity to DacA (PBP5) and DacC (PBP6) . [More information is available at EcoCyc: EG11893].
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    Genomic context

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    Sequence:
    NC_000913.3 (2081381..2082547, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative transporter YeeA Neighboring gene DNA gyrase inhibitor Neighboring gene exodeoxyribonuclease I Neighboring gene putative thiosulfate sulfurtransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Redundancy of Peptidoglycan Carboxypeptidases Ensures Robust Cell Shape Maintenance in Escherichia coli. Peters K, et al. mBio, 2016 Jun 21. PMID 27329754, Free PMC Article
    2. Moderate deacylation efficiency of DacD explains its ability to partially restore beta-lactam resistance in Escherichia coli PBP5 mutant. Chowdhury C, et al. FEMS Microbiol Lett, 2012 Dec. PMID 22978571
    3. Sequences near the active site in chimeric penicillin binding proteins 5 and 6 affect uniform morphology of Escherichia coli. Ghosh AS, et al. J Bacteriol, 2003 Apr. PMID 12644487, Free PMC Article
    4. dacD, an Escherichia coli gene encoding a novel penicillin-binding protein (PBP6b) with DD-carboxypeptidase activity. Baquero MR, et al. J Bacteriol, 1996 Dec. PMID 8955390, Free PMC Article
    5. Contribution of membrane-binding and enzymatic domains of penicillin binding protein 5 to maintenance of uniform cellular morphology of Escherichia coli. Nelson DE, et al. J Bacteriol, 2002 Jul. PMID 12057958, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables beta-lactamase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables carboxypeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables carboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carboxypeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables penicillin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type D-Ala-D-Ala carboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type D-Ala-D-Ala carboxypeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptidoglycan biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within peptidoglycan metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within peptidoglycan metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of cell shape EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of cell shape IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    D-alanyl-D-alanine carboxypeptidase DacD
    NP_416514.4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2081381..2082547 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416514.4 D-alanyl-D-alanine carboxypeptidase DacD [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416514.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376M673, A0A6N0IQT3, A0AAN5UE27
      Conserved Domains (1) summary
      PRK11397
      Location:1 → 388
      dacD; serine-type D-Ala-D-Ala carboxypeptidase DacD
    Nucleotide Protein
    Heading Accession and Version

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