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    kdpC K(+) transporting P-type ATPase subunit KdpC [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947508, updated on 17-Dec-2024

    Summary

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    Official Symbol
    kdpC
    Official Full Name
    K(+) transporting P-type ATPase subunit KdpC
    Primary source
    ECOCYC:EG10515
    Locus tag
    b0696
    See related
    ASAP:ABE-0002374
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0684; kac
    Summary
    The kdpFABC genes encode an ATP-dependent high affinity P-Type ATPase potassium ion transporter . [More information is available at EcoCyc: EG10515].
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    Genomic context

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    Sequence:
    NC_000913.3 (724407..724979, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene leader peptide SpeFL Neighboring gene DNA-binding transcriptional activator KdpE Neighboring gene sensor histidine kinase KdpD Neighboring gene K(+) transporting P-type ATPase subunit KdpB Neighboring gene K(+) transporting P-type ATPase subunit KdpA Neighboring gene K(+) transporting P-type ATPase subunit KdpF

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ATP binding properties of the soluble part of the KdpC subunit from the Escherichia coli K(+)-transporting KdpFABC P-type ATPase. Ahnert F, et al. Biochemistry, 2006 Sep 12. PMID 16953591
    2. The KdpC subunit of the Escherichia coli K+-transporting KdpB P-type ATPase acts as a catalytic chaperone. Irzik K, et al. FEBS J, 2011 Sep. PMID 21711450
    3. ATP-driven potassium transport in right-side-out membrane vesicles via the Kdp system of Escherichia coli. Kollmann R, et al. Biochim Biophys Acta, 1993 Jun 10. PMID 8499455
    4. FITC binding site and p-nitrophenyl phosphatase activity of the Kdp-ATPase of Escherichia coli. Bramkamp M, et al. Biochemistry, 2004 Apr 20. PMID 15078102
    5. Identification of the structural proteins of an ATP-driven potassium transport system in Escherichia coli. Laimins LA, et al. Proc Natl Acad Sci U S A, 1978 Jul. PMID 356049, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural basis for potassium transport in prokaryotes by KdpFABC.
      Title: Structural basis for potassium transport in prokaryotes by KdpFABC.
    2. Data indicate that KdpFABC P-type ATPase activity could be stimulated not only by the presence of the transported K+ ions in a pH-dependent manner but also, to a significantly lesser extent, by H+ and Na+.
      Title: Mechanistic analysis of the pump cycle of the KdpFABC P-type ATPase.
    3. Data suggest that high-affinity ATP binding to KdpFABC is dependent on conserved Gln in KdpC; that ATP binding to KdpC and ATP hydrolysis by KdpFABC are sensitive to accessibility of ribose hydroxyls; and that KdpC binds with KdpB ATP-binding loop.
      Title: The KdpC subunit of the Escherichia coli K+-transporting KdpB P-type ATPase acts as a catalytic chaperone.
    4. Data show that the increase in the anionic lipid composition enhances the expression rate of the kdpFABC operon.
      Title: Influence of K+-dependent membrane lipid composition on the expression of the kdpFABC operon in Escherichia coli.
    5. review K+-translocating KdpFABC complex: KdpC might act as a catalytical chaperone, which cooperatively interacts with the nucleotide to be hydrolyzed
      Title: The K+-translocating KdpFABC complex from Escherichia coli: a P-type ATPase with unique features.
    6. ATP binding occurred within the Val144-Lys161 peptide located within the C-terminal part of KdpC
      Title: ATP binding properties of the soluble part of the KdpC subunit from the Escherichia coli K(+)-transporting KdpFABC P-type ATPase.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables P-type potassium transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables P-type potassium transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables P-type potassium transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within monoatomic cation transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within potassium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within potassium ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in potassium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    part_of potassium ion-transporting ATPase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of potassium:proton antiporter complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    K(+) transporting P-type ATPase subunit KdpC
    NP_415224.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      724407..724979 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415224.1 K(+) transporting P-type ATPase subunit KdpC [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415224.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A1X3JLF8
      Conserved Domains (1) summary
      PRK00315
      Location:1 → 188
      PRK00315; potassium-transporting ATPase subunit KdpC
    Nucleotide Protein
    Heading Accession and Version

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