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    ridA enamine/imine deaminase, redox-regulated chaperone [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948771, updated on 17-Dec-2024

    Summary

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    Official Symbol
    ridA
    Official Full Name
    enamine/imine deaminase, redox-regulated chaperone
    Primary source
    ECOCYC:G7877
    Locus tag
    b4243
    See related
    ASAP:ABE-0013886
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4238; yjgF
    Summary
    YjgF, RutC, TdcF, YoaB and YjgH are paralogs and members of a highly conserved YjgF family (pfam:PF01042) with diverse mutant phenotypes and unknown molecular function; the family members form homotrimers, some binding 2-ketoglutarate or related compounds. [More information is available at EcoGene: EG12524]. A crystal structure of Escherichia coli YjgF is presented at 1.2 A resolution . [More information is available at EcoCyc: G7877].
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    Genomic context

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    Sequence:
    NC_000913.3 (4470527..4470913, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene leader peptide MgtL Neighboring gene Mg(2(+)) importing P-type ATPase Neighboring gene aspartate carbamoyltransferase, PyrI subunit Neighboring gene aspartate carbamoyltransferase catalytic subunit

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Activation of RidA chaperone function by N-chlorination. Müller A, et al. Nat Commun, 2014 Dec 17. PMID 25517874, Free PMC Article
    2. Redox proteomics uncovers peroxynitrite-sensitive proteins that help Escherichia coli to overcome nitrosative stress. Lindemann C, et al. J Biol Chem, 2013 Jul 5. PMID 23696645, Free PMC Article
    3. The ridA gene of E. coli is indirectly regulated by BglG through the transcriptional regulator Lrp in stationary phase. Shukla S, et al. Microbiology (Reading), 2019 Jun. PMID 31063124
    4. Structure-based ligand binding sites of protein p14.5, a member of protein family YER057c/YIL051c/YjgF. Mistiniene E, et al. Int J Biol Macromol, 2005 Oct 30. PMID 16198412
    5. PurF-independent phosphoribosyl amine formation in yjgF mutants of Salmonella enterica utilizes the tryptophan biosynthetic enzyme complex anthranilate synthase-phosphoribosyltransferase. Browne BA, et al. J Bacteriol, 2006 Oct. PMID 16980480, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Enamine/imine deaminase (ridA) is positively regulated by leucine responsive regulatory protein (Lrp). Lrp is indirectly regulated by BglG, which brings about the overexpression of ridA in beta-glucoside operon (bgl)(+) strains during stationary phase. Loss of ridA function in a Bgl(+) background results in a growth retardation in serine-containing media compared to that in a Bgl(-) background.
      Title: The ridA gene of E. coli is indirectly regulated by BglG through the transcriptional regulator Lrp in stationary phase.
    2. Post-translational chlorination activates RidA turning in it to a chaperone.
      Title: Activation of RidA chaperone function by N-chlorination.
    3. N-terminus verified by Edman degradation on mature peptide
      Title: Small genes/gene-products in Escherichia coli K-12.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 2-iminobutanoate deaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 2-iminobutanoate deaminase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables 2-iminobutanoate/2-iminopropanoate deaminase IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 2-iminopropanoate deaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables deaminase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables deaminase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables unfolded protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in isoleucine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein homotrimerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to toxic substance IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to toxic substance IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane HDA PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    enamine/imine deaminase, redox-regulated chaperone

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4470527..4470913 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418664.2 enamine/imine deaminase, redox-regulated chaperone [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418664.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0AAJ3TZ02, A0AAN3MAC5, Q8XCD0
      Conserved Domains (1) summary
      cl10015
      Location:1 → 127
      YjgF_YER057c_UK114_family; YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no ...
    Nucleotide Protein
    Heading Accession and Version

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