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    cobC putative adenosylcobalamin phosphatase/alpha-ribazole phosphatase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945246, updated on 3-Dec-2024

    Summary

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    Official Symbol
    cobC
    Official Full Name
    putative adenosylcobalamin phosphatase/alpha-ribazole phosphatase
    Primary source
    ECOCYC:G6349
    Locus tag
    b0638
    See related
    ASAP:ABE-0002185
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0631; phpB
    Summary
    Primarily characterized in Salmonella. [More information is available at EcoGene: EG13240]. In Salmonella typhimurium, the cobC gene encodes the -ribazole-5'-P phosphatase in the cobalamin biosynthetic pathway . [More information is available at EcoCyc: G6349].
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    Genomic context

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    Sequence:
    NC_000913.3 (669296..669907, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene 23S rRNA m(3)psi1915 methyltransferase Neighboring gene ribosomal silencing factor RsfS Neighboring gene nicotinate-nucleotide adenylyltransferase Neighboring gene DNA polymerase III subunit delta Neighboring gene lipopolysaccharide assembly protein LptE

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The cobC gene of Salmonella typhimurium codes for a novel phosphatase involved in the assembly of the nucleotide loop of cobalamin. O'Toole GA, et al. J Biol Chem, 1994 Oct 21. PMID 7929373
    2. Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Hayashi K, et al. Mol Syst Biol, 2006. PMID 16738553, Free PMC Article
    3. The complete genome sequence of Escherichia coli K-12. Blattner FR, et al. Science, 1997 Sep 5. PMID 9278503
    4. Escherichia coli K-12: a cooperatively developed annotation snapshot--2005. Riley M, et al. Nucleic Acids Res, 2006. PMID 16397293, Free PMC Article
    5. The histidine phosphatase superfamily: structure and function. Rigden DJ. Biochem J, 2008 Jan 15. PMID 18092946

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables alpha-ribazole phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cobalamin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    putative adenosylcobalamin phosphatase/alpha-ribazole phosphatase
    NP_415171.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      669296..669907 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415171.1 putative adenosylcobalamin phosphatase/alpha-ribazole phosphatase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415171.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A1X3JKR0
      Conserved Domains (1) summary
      PRK15004
      Location:1 → 198
      PRK15004; adenosylcobalamin/alpha-ribazole phosphatase
    Nucleotide Protein
    Heading Accession and Version

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