U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    cspD DNA replication inhibitor CspD [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945669, updated on 3-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    cspD
    Official Full Name
    DNA replication inhibitor CspD
    Primary source
    ECOCYC:EG11111
    Locus tag
    b0880
    See related
    ASAP:ABE-0002991
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    cspH; ECK0871; ybjA
    Summary
    CspD forms a homodimer in solution and is able to bind single-stranded DNA and RNA and packs ssDNA into structures that are distinguishable from SSB-coated DNA. [More information is available at EcoCyc: EG11111].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (922366..922590, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF2813 domain-containing protein YbjD Neighboring gene DUF535 domain-containing protein YbjX Neighboring gene ABC-type tripartite efflux pump membrane fusion protein Neighboring gene ABC-type tripartite efflux pump ATP binding/membrane subunit Neighboring gene protein YljB Neighboring gene specificity factor for ClpA-ClpP chaperone-protease complex

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The product of unr, the highly conserved gene upstream of N-ras, contains multiple repeats similar to the cold-shock domain (CSD), a putative DNA-binding motif. Doniger J, et al. New Biol, 1992 Apr. PMID 1622933
    2. Growth-phase-dependent expression of cspD, encoding a member of the CspA family in Escherichia coli. Yamanaka K, et al. J Bacteriol, 1997 Aug. PMID 9260955, Free PMC Article
    3. The Escherichia coli replication inhibitor CspD is subject to growth-regulated degradation by the Lon protease. Langklotz S, et al. Mol Microbiol, 2011 Jun. PMID 21435040
    4. Different in vivo localization of the Escherichia coli proteins CspD and CspA. Giangrossi M, et al. FEMS Microbiol Lett, 2001 Aug 21. PMID 11520610
    5. The ATP-dependent Clp protease of Escherichia coli. Sequence of clpA and identification of a Clp-specific substrate. Gottesman S, et al. J Biol Chem, 1990 May 15. PMID 2186030

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of Attenuators of Transcriptional Termination: Implications for RNA Regulation in Escherichia coli.
      Title: Identification of Attenuators of Transcriptional Termination: Implications for RNA Regulation in Escherichia coli.
    2. The results from in vitro transcription assays demonstrated that CRP activates PcspD transcription in the absence of additional factors other than RNA polymerase.
      Title: Cyclic AMP receptor protein regulates cspD, a bacterial toxin gene, in Escherichia coli.
    3. CspD is subject to growth-regulated degradation by the Lon protease.
      Title: The Escherichia coli replication inhibitor CspD is subject to growth-regulated degradation by the Lon protease.
    4. The MqsR/MqsA TA system controls cell physiology via its own toxicity as well as through its regulation of another toxin, CspD.
      Title: Escherichia coli toxin/antitoxin pair MqsR/MqsA regulate toxin CspD.
    5. N-terminus verified by Edman degradation on complete protein
      Title: Small genes/gene-products in Escherichia coli K-12.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables toxin activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in modulation of process of another organism IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of DNA replication IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within response to starvation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    DNA replication inhibitor CspD

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      922366..922590 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415401.1 DNA replication inhibitor CspD [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415401.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A192CKS7, A0AA36KVR3, Q1RE43
      Conserved Domains (1) summary
      cl09927
      Location:1 → 74
      S1_like; Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain. Both domains ...
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.